Troels Herlin
A5057121855- Autoimmune and Inflammatory Disorders Research
- Adolescent and Pediatric Healthcare
- Rheumatoid Arthritis Research and Therapies
- Inflammasome and immune disorders
- Temporomandibular Joint Disorders
- Childhood Cancer Survivors' Quality of Life
- Kawasaki Disease and Coronary Complications
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Acute Lymphoblastic Leukemia research
- Immunodeficiency and Autoimmune Disorders
- Osteomyelitis and Bone Disorders Research
- Otitis Media and Relapsing Polychondritis
- Systemic Lupus Erythematosus Research
- Psoriasis: Treatment and Pathogenesis
- Orthopedic Infections and Treatments
- Pediatric Pain Management Techniques
- Osteoarthritis Treatment and Mechanisms
- Spondyloarthritis Studies and Treatments
- Musculoskeletal Disorders and Rehabilitation
- Immune Cell Function and Interaction
- Family and Disability Support Research
- Orthodontics and Dentofacial Orthopedics
- Pediatric health and respiratory diseases
- Ocular Diseases and Behçet’s Syndrome
Aarhus University Hospital
2016-2025
Aarhus University
2013-2024
Sahlgrenska University Hospital
2022
Massachusetts General Hospital
2019
Harvard University
2019
Boston Children's Hospital
2019
Istituto Giannina Gaslini
2013-2018
Pediatrics and Genetics
2016
Novo Nordisk Foundation
2015
Lundbeck Foundation
2015
Detailed quantitative studies were performed on the generation and utilization of energy by resting phagocytosing human neutrophils. The ATP content was 1.9 fmol/cell, constant during rest, not influenced presence or absence glucose in medium. intracellular phosphocreatine less than 0.2 fmol/cell.
The objective of this work was to develop and validate a set clinical criteria for the classification patients affected by periodic fevers. Patients with inherited fevers (familial Mediterranean fever (FMF); mevalonate kinase deficiency (MKD); tumour necrosis factor receptor-associated syndrome (TRAPS); cryopyrin-associated syndromes (CAPS)) enrolled in Eurofever Registry up until March 2013 were evaluated. fever, aphthosis, pharyngitis adenitis (PFAPA) used as negative controls. For each...
Abstract Objective To describe the disease characteristics, long‐term course, and outcome of patients with juvenile idiopathic arthritis (JIA) in a population‐based setting. Methods Consecutive cases JIA from defined geographic areas Denmark, Finland, Sweden, Norway whom onset occurred 1997–2000 were included prospective, multicenter cohort study. The study was designed to be as close possible, centers participating only if they able include their catchment area all children diagnosed....
<h3>Background and objective</h3> Majeed syndrome is an autosomal recessive disorder characterised by the triad of chronic recurrent multifocal osteomyelitis, congenital dyserythropoietic anaemia a neutrophilic dermatosis that caused mutations in <i>LPIN2</i>. Long-term outcome poor. This first report detailing treatment with biological agents demonstrates clinical improvement IL-1blockade. <h3>Methods</h3> We describe presentation, genetic analysis, cytokine profiles response to therapy two...
Chronic non-bacterial osteomyelitis (CNO) or chronic recurrent multifocal (CRMO) is an autoinflammatory disorder characterized by sterile bone osteolytic lesions. The aim of this study was to evaluate the demographic data and clinical, instrumental therapeutic features at baseline in a large series CNO/CRMO patients enrolled Eurofever registry. A web-based registry collected retrospective on affected CRMO/CNO. Both paediatric adult centres were involved. Complete information 486 available...
The present study was undertaken to assess the long-term course, remission rate, and disease burden in juvenile idiopathic arthritis (JIA) 18 years after onset a population-based setting from early biologic era.A total of 510 consecutive cases JIA with between 1997 2000 defined geographic regions Denmark, Norway, Sweden, Finland were prospectively included this 18-year cohort study. At follow-up visit, patient-reported demographic clinical data collected.The 434 (85%) eligible participants....
Musculoskeletal ultrasonography (US) has the potential to be an important tool in assessment of disease activity childhood arthritides. To assess pathology, clear definitions for synovitis need developed first. The aim this study was develop and validate these through international consensus process.The decision on which US techniques use components included definitions, as well final wording, were by 31 experts a process. A Likert scale 1-5 (where 1 = complete disagreement 5 agreement)...
Abstract Background Granulomatosis with polyangiitis (GPA), formerly known as Wegener’s granulomatosis (WG), belongs to the group of ANCA-associated necrotizing vasculitides. This study describes clinical picture disease in a large cohort GPA paediatric patients. Children age at diagnosis ≤ 18 years, fulfilling EULAR/PRINTO/PRES GPA/WG classification criteria were extracted from PRINTO vasculitis database. The signs/symptoms and laboratory features analysed before or time least 3 months...
Objective. Loss of joint cartilage may be an early feature chronic inflammatory diseases like juvenile idiopathic arthritis (JIA). Conventional radiography usually detects only late changes such as space narrowing and bone erosion rather than changes. Joint is easily visualized with high-frequency ultrasonography (US), but age- gender-related normal standard reference values should established before US measurement thickness becomes procedure in the clinic. Methods. A cross-sectional study...
Objective: To evaluate a group of 53 patients with juvenile dermatomyositis (JDM), on average 13.9 years after disease onset, in order to describe the long-term outcome and identify disease-related parameters associated poor outcome.
To compare the juvenile arthritis disease activity score (JADAS) based on C reactive protein (CRP) (JADAS-CRP) with JADAS erythrocyte sedimentation rate (ESR) (JADAS-ESR) and to validate in a population-based setting.The CRP ESR values corresponding scores (JADAS10/27/71) were compared longitudinal cohort study of 389 children newly diagnosed idiopathic (JIA) Nordic JIA study. The construct validity discriminative predictive ability assessed during median course 8 years by comparing other...
Objectives Autoinflammatory diseases cause systemic inflammation that can result in damage to multiple organs. A validated instrument is essential quantify individual patients and compare disease outcomes clinical studies. Currently, there no such tool. Our objective was develop a common autoinflammatory index (ADDI) for familial Mediterranean fever, cryopyrin-associated periodic syndromes, tumour necrosis factor receptor-associated fever syndrome mevalonate kinase deficiency. Methods We...
The incidence of uveitis associated with juvenile idiopathic arthritis (JIA) varies around the world. Our aim was to investigate and predictors in a Nordic population-based cohort. Consecutive JIA cases from defined geographical areas Denmark, Finland, Sweden Norway disease onset between January 1997 June 2000 were followed for median 98 months this prospective longitudinal cohort study. Potential clinical immunological identified logistic regression analysis. Uveitis occurred 89 (20.5%) 435...