A5091508123- Autoimmune and Inflammatory Disorders Research
- Adolescent and Pediatric Healthcare
- Rheumatoid Arthritis Research and Therapies
- Kawasaki Disease and Coronary Complications
- Otitis Media and Relapsing Polychondritis
- Inflammasome and immune disorders
- Acute Lymphoblastic Leukemia research
- Ocular Diseases and Behçet’s Syndrome
- Temporomandibular Joint Disorders
- Childhood Cancer Survivors' Quality of Life
- Immunodeficiency and Autoimmune Disorders
- Pediatric health and respiratory diseases
- Spondyloarthritis Studies and Treatments
- Renal Diseases and Glomerulopathies
- Systemic Lupus Erythematosus Research
- Neonatal Respiratory Health Research
- Family and Disability Support Research
- Inflammation biomarkers and pathways
- Psoriasis: Treatment and Pathogenesis
- Osteomyelitis and Bone Disorders Research
- Orthodontics and Dentofacial Orthopedics
- Child and Adolescent Health
- Inclusion and Disability in Education and Sport
- Gout, Hyperuricemia, Uric Acid
- Delphi Technique in Research
Aarhus University Hospital
2015-2025
Aarhus University
2022-2025
University of Calgary
2024
Emory University
2024
American College of Rheumatology
2022
Norwegian University of Science and Technology
2019
UiT The Arctic University of Norway
2019
Levanger Hospital
2019
University of Helsinki
2019
University Hospital of North Norway
2019
The present study was undertaken to assess the long-term course, remission rate, and disease burden in juvenile idiopathic arthritis (JIA) 18 years after onset a population-based setting from early biologic era.A total of 510 consecutive cases JIA with between 1997 2000 defined geographic regions Denmark, Norway, Sweden, Finland were prospectively included this 18-year cohort study. At follow-up visit, patient-reported demographic clinical data collected.The 434 (85%) eligible participants....
PurposeTo assess the long-term outcome of uveitis in juvenile idiopathic arthritis (JIA).DesignPopulation-based, multicenter, prospective JIA cohort, with a cross-sectional assessment JIA-associated (JIA-U) 18 years after onset JIA.ParticipantsA total 434 patients JIA, whom 96 had uveitis, from defined geographic areas Denmark, Finland, Norway, and Sweden.MethodsPatients between January 1997 June 2000 were prospectively followed for years. Pediatric rheumatologists ophthalmologists collected...
Objective. To determine the prevalence of orofacial symptoms, dysfunctions, and deformities temporomandibular joint (TMJ) in juvenile idiopathic arthritis (JIA) 17 years after disease onset. Methods. Drawn from a prospective, population-based Nordic JIA cohort with onset 1997 to 2000, 420 consecutive cases were eligible for evaluation TMJ involvement. The followup visit included demographic data, standardized clinical examination, full-face cone-beam computed tomography (CBCT). For...
Objective To evaluate the long-term safety profile of anakinra in patients with systemic juvenile idiopathic arthritis (sJIA). Methods Data from sJIA enrolled Pharmachild registry ( ClinicalTrials.gov : NCT03932344 ) prior to September 30, 2018, and treated were analyzed. The study endpoints occurrence non-serious adverse events (SAEs) at least moderate severity SAEs, including macrophage activation syndrome (MAS), duration treatment reasons for discontinuation. All analyzed overall by...
The aim was to develop prediction rules that may guide early treatment decisions based on baseline clinical predictors of long-term unfavorable outcome in juvenile idiopathic arthritis (JIA).In the Nordic JIA cohort, we assessed disease characteristics as following outcomes 8 years after onset. Non-achievement remission off medication according preliminary Wallace criteria, functional disability by Childhood Health Assessment Questionnaire (CHAQ) and Physical Summary Score (PhS) Child...
Objective To estimate the cumulative incidence of arthritis‐induced orofacial symptoms, dysfunction, and dentofacial deformities in growing individuals with juvenile idiopathic arthritis ( JIA ) a 36‐month regional cohort study to identify predictors for development deformities. Methods Data were retrieved from Aarhus temporomandibular joint TMJ register, which contains standardized, longitudinal, observational data regarding conditions patients (n = 1,040). This represents majority all...
To estimate the cumulative incidences of orofacial conditions related to temporomandibular joint (TMJ) juvenile idiopathic arthritis (JIA) between diagnosis in childhood transition into adult care, and identify features JIA associated with TMJ involvement.A population-based cohort analysis was conducted patients involving longitudinal data on health from 2000 2018. Regardless status, were referred Regional Specialist Craniofacial Clinic Western Denmark for routine examinations. Data...
Objectives To identify long-term disease activity trajectories from childhood to adulthood by using the clinical Juvenile Arthritis Disease Activity Score (cJADAS10) in juvenile idiopathic arthritis (JIA). Second, evaluate contribution of cJADAS10 components and explore characteristics associated with active at 18-year follow-up. Methods Patients onset JIA 1997–2000 were followed for 18 years population-based Nordic cohort. We used a discrete mixture model longitudinal clustering its...
Objectives. Chronic nonbacterial osteomyelitis (CNO) is a sterile inflammatory bone disorder with an unpredictable disease course. The objective was to assess clinical and radiological activity in children CNO including response early-onset pamidronate treatment. Methods. A single-center retrospective study conducted of fulfilling the Bristol Criteria for CNO. At time diagnosis, whole-body magnetic resonance imaging (WB-MRI) or local MRI performed activity. Children multifocal spinal...
We have previously shown that HLA-B27 was negatively associated with remission status eight years after the onset of juvenile idiopathic arthritis (JIA). now aimed to study associations clinical features and disease outcomes 18 JIA. studied 434 patients from population-based Nordic JIA cohort. Demographic data, including status, were collected consecutively at baseline, onset, presented in relation status. The available for 416 participants (96%) positive 93 (22.4%), more often men (P =...
Objectives We aimed to develop consensus‐based recommendations for the monitoring of children with Juvenile Idiopathic Arthritis‐associated uveitis (JIAU) in long‐term remission, addressing absence international guidance on schedules these and young people. Methods The Multinational Interdisciplinary Working Group Uveitis Childhood (MIWGUC) convened experts from ten countries, including paediatric rheumatologists ophthalmologists, alongside parents affected children. A review key...
To characterize the existing national and multi-national registries cohort studies in juvenile idiopathic arthritis (JIA) identify differences as well areas of potential future collaboration. We surveyed investigators from North America, Europe, Australia about JIA registries. excluded cross-sectional studies. captured information study design, duration, location, inclusion criteria, data elements collection methods. received survey results 18 studies, including 11 7 representing 37...
The aim of the study was to describe school attendance and participation in physical education among children with juvenile idiopathic arthritis (JIA). Consecutive cases JIA from defined geographical areas Finland, Sweden Norway disease onset 1997 2000 were followed for 8 years a multi-center cohort study, aimed be as close population-based possible. Clinical characteristics information on (PE) registered. Participation PE lowest initially increased during course. Eight after 228/274 (83.2%)...
To study for the first-time, pain perception, sensitivity, and self-reported in young adults with long disease duration of juvenile idiopathic arthritis (JIA) compared controls.Children from Central Norway diagnosed JIA between 1997 2004 were included consecutively a population-based prospective study. Children onset 1997-2000 part Nordic cohort. Controls age- sex-matched. In 2015-2017, visits investigator-blinded quantitative sensory testing (QST) comprising cold warm detection thresholds...
To study self-reported pain early in the disease course of juvenile idiopathic arthritis (JIA) as a predictor long-term outcomes.Consecutive cases JIA with onset from 1997 to 2000 defined geographical areas Norway, Sweden, Finland, and Denmark were prospectively enrolled this population-based cohort study. Self-reported, disease-related was measured on 10-cm visual analog scale (VAS pain). Inclusion criteria baseline visit score 6 months after onset, followed by an 8-year visit. Remission...
Objective Acute lymphoblastic leukemia (ALL) may present with arthritis implying the risk of being misdiagnosed as juvenile idiopathic (JIA). The aim this study was to identify predictors for ALL based on clinical and laboratory information. Methods This cross-sectional, retrospective compared presentation results 26 children versus 485 JIA (433 non-systemic, 52 systemic JIA). Using a Bayesian score approach findings were evaluated by calculating odds ratios (OR) lnOR measure diagnostic...
Abstract Background Differential diagnosis in children with signs of unprovoked inflammation can be challenging. In particular, differentiating systemic juvenile idiopathic arthritis (SJIA) from other diagnoses is difficult. We have recently validated the complex myeloid-related proteins 8/14 (MRP8/14, also known as S100A8/A9 or serum calprotectin) a helpful biomarker supporting SJIA. The results were subsequently confirmed commercial ELISA. However, further optimization analytical...