Alma Nunzia Olivieri
A5087309422- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Adolescent and Pediatric Healthcare
- Kawasaki Disease and Coronary Complications
- Immunodeficiency and Autoimmune Disorders
- Acute Lymphoblastic Leukemia research
- Ocular Diseases and Behçet’s Syndrome
- Orthopedic Infections and Treatments
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Chronic Lymphocytic Leukemia Research
- Infectious Diseases and Tuberculosis
- Otitis Media and Relapsing Polychondritis
- Eosinophilic Disorders and Syndromes
- IL-33, ST2, and ILC Pathways
- Osteomyelitis and Bone Disorders Research
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Sarcoidosis and Beryllium Toxicity Research
- Drug-Induced Adverse Reactions
- Pharmaceutical studies and practices
- Diabetes and associated disorders
- Congenital heart defects research
- Urticaria and Related Conditions
University of Campania "Luigi Vanvitelli"
2014-2024
University of Lisbon
2023
Amsterdam University Medical Centers
2023
Aalborg University
2023
Odense University Hospital
2023
Azienda Ospedaliera Universitaria Università degli Studi della Campania Luigi Vanvitelli
2020-2022
Committee on Publication Ethics
2021
Weatherford College
2021
University of Naples Federico II
1992-2020
Istituto Giannina Gaslini
2019
<h3>Objectives</h3> To validate the previously proposed classification criteria for Henoch–Schönlein purpura (HSP), childhood polyarteritis nodosa (c-PAN), c-Wegener granulomatosis (c-WG) and c-Takayasu arteritis (c-TA). <h3>Methods</h3> Step 1: retrospective/prospective web-data collection children with HSP, c-PAN, c-WG c-TA age at diagnosis ≤18 years. 2: blinded by consensus panel of a representative sample 280 cases. 3: statistical (sensitivity, specificity, area under curve κ-agreement)...
Background and objectives: few studies have reported the drug retention rate (DRR) of biologic drugs in juvenile idiopathic arthritis (JIA), none them has specifically investigated DRR interleukin (IL)-1 inhibitors on systemic JIA (sJIA). This study aims to describe IL-1 evaluate predictive factors survival based data from a real-world setting concerning sJIA. Methods: Medical records sJIA patients treated with anakinra (ANA) canakinumab (CAN) were retrospectively analyzed 15 Italian...
The objective of this work was to develop and validate a set clinical criteria for the classification patients affected by periodic fevers. Patients with inherited fevers (familial Mediterranean fever (FMF); mevalonate kinase deficiency (MKD); tumour necrosis factor receptor-associated syndrome (TRAPS); cryopyrin-associated syndromes (CAPS)) enrolled in Eurofever Registry up until March 2013 were evaluated. fever, aphthosis, pharyngitis adenitis (PFAPA) used as negative controls. For each...
Background: interleukin (IL)-1 inhibitors have been suggested as possible therapeutic options in a large number of old and new clinical entities characterized by an IL-1 driven pathogenesis. Objectives: to perform nationwide snapshot the on-label off-label use anakinra (ANA) canakinumab (CAN) for different conditions both children adults. Methods: we retrospectively collected demographic, clinical, data from adult pediatric patients treated with January 2008 July 2016. Results: 526 treatment...
<h3>Objectives</h3> Systemic auto-inflammatory disorders (SAIDs) are a heterogeneous group of monogenic diseases sharing primary dysfunction the innate immune system. More than 50% patients with SAID does not show any mutation at gene(s) tested because lack precise clinical classification criteria and/or incomplete gene screening. To improve molecular diagnosis and genotype interpretation SAIDs, we undertook development next-generation sequencing (NGS)-based protocol designed to simultaneous...
Behçet's disease is a rare multi-systemic inflammatory with unknown etiology which involves principally oral and genital mucosa, skin eyes. Average age at onset of the about 25-30 years, but it may be diagnosed before 16. It not very in Italy, even though there are limited data concerning epidemiology. Aim this study to describe baseline an Italian cohort patients as having BD or probable BD. We described first national epidemiological on children coming from 16 Pediatric Rheumatologic...
To describe the clinical characteristics, treatment response and genetic findings in a large cohort of patients with undefined systemic autoinflammatory diseases (SAIDs).Clinical data from SAIDs were extracted Eurofever registry, an international web-based registry that retrospectively collects information on diseases.This study included 187 patients. Seven had chronic disease course, 180 recurrent course. The median age at onset was 4.3 years. Patients 12 episodes per year, duration 4 days....
Abstract Objective To validate and promulgate a core set of outcome measures for the evaluation response to treatment in patients with juvenile systemic lupus erythematosus (SLE). Methods In 2001, preliminary consensus‐derived evaluating therapy SLE was established. present study, validated through an evidence‐based, large‐scale data collection process that led enrollment 557 from 39 different countries. Consecutive active disease were assessed at baseline after 6 months. The validation...
Abstract Objective The aim of this study was to report the interim 5-year safety and effectiveness abatacept in patients with JIA PRINTO/PRCSG registry. Methods Abatacept Registry (NCT01357668) is an ongoing observational children receiving abatacept; enrolment started January 2013. Clinical sites enrolled starting or currently abatacept. Eligible were assessed for (primary end point) over 10 years. Effectiveness measured by clinical 10-joint Juvenile Arthritis Disease Activity Score...
Objective The aim of this paper is to present the AutoInflammatory Disease Alliance (AIDA) international Registry dedicated Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic (VEXAS) syndrome, describing its design, construction, and modalities dissemination. Methods This a clinical, physician-driven, population- electronic-based instrument designed for retrospective prospective collection real-life data. Data gathering based on Research Electronic Capture (REDCap) tool intended obtain...
Data from routine clinical practice are needed to further define the efficacy and safety of biologic medications in children with juvenile idiopathic arthritis (JIA). The aim this analysis was investigate disease status, reasons for discontinuation adverse events Italian JIA patients treated etanercept (ETN). In 2013, all centers Pediatric Rheumatology Study Group were asked make a census given ETN after January 2000. Patients classified three groups: group 1 = still taking ETN; 2...
Background and objective: Only a few studies have reported long-term efficacy of interleukin (IL)-1 inhibition in systemic juvenile idiopathic arthritis (sJIA) adult onset Still disease (AOSD). Herein we report on the effectiveness Anakinra (ANA), expressed terms drug retention rate (DRR), evaluate predictive factors survival patients with both sJIA AOSD. Patients methods: This is multicentre study reviewing retrospectively medical records from 61 76 AOSD treated ANA 25 Italian tertiary...
Abstract Background Systemic autoinflammatory disorders (SAIDs) represent a growing spectrum of diseases characterized by dysregulation the innate immune system. The most common pediatric fever syndrome, Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis (PFAPA), has well defined clinical diagnostic criteria, but there is subset patients who do not meet these criteria and are classified as undefined (uAID). This project, endorsed PRES, supported EMERGE fellowship program, aimed to...
Growth in height was studied 58 patients with juvenile rheumatoid arthritis (JRA) followed for 4.9 +/- (SD) 2.8 years, who had never received steroids. Height measurements were converted to Z Scores. scores at first and last visit respectively 0.7 1 0.9 (NS) pauciarticular, 0 1.6 -0.55 (p = 0.045) systemic, 0.29 0.8 -0.4 0.0001) polyarticular JRA patients. In systemic a significant negative relation found between the duration of disease delta score 0.0008) as well sum periods active 0.0001)....
The present manuscript aims to describe an international, electronic-based, user-friendly and interoperable patient registry for monogenic autoinflammatory diseases (mAIDs), developed in the contest of Autoinflammatory Diseases Alliance (AIDA) Network.This is electronic platform, based on Research Electronic Data Capture (REDCap) tool, used real-world data collection demographics, clinical, laboratory, instrumental socioeconomic mAIDs patients. instrument has flexibility, may change over...
This study aims to describe musculoskeletal manifestations (MSM) in children with Behçet's syndrome (BS), their association other disease manifestations, response therapy, and long-term prognosis. Data were retrieved from the AIDA Network Syndrome Registry. Out of a total 141 patients juvenile BS, 37 had MSM at onset (26.2%). The median age was 10.0 years (IQR 7.7). follow-up duration 21.8 23.3). Recurrent oral (100%) genital ulcers (67.6%) pseudofolliculitis (56.8%) most common symptoms...
To develop parent- and child-centered versions of the Juvenile Arthritis Disease Activity Score (JADAS) to provide preliminary evidence their validity.
Acute/subacute haematogenous osteomyelitis (AHOM/SAHOM) are potentially devastating diseases. Updated information about the epidemiology, management and outcome of AHOM/SAHOM is needed to minimize risk complications sequelae.A multicenter study was performed evaluate retrospectively in Italy. Data from children aged >1 month, hospitalized between 2010 2016, 19 pediatric centers, were analyzed.300 with AHOM 98 SAHOM included. Median age 6.0 years (IQR: 2.0-11.0). No clinical difference...