Andrzej Krzysztofiak
A5016989303- Orthopedic Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- COVID-19 Clinical Research Studies
- Infectious Diseases and Tuberculosis
- Streptococcal Infections and Treatments
- Long-Term Effects of COVID-19
- Herpesvirus Infections and Treatments
- Osteomyelitis and Bone Disorders Research
- Kawasaki Disease and Coronary Complications
- Respiratory viral infections research
- Neonatal and Maternal Infections
- SARS-CoV-2 and COVID-19 Research
- Virology and Viral Diseases
- Infective Endocarditis Diagnosis and Management
- COVID-19 Impact on Reproduction
- Vector-borne infectious diseases
- Hematological disorders and diagnostics
- Child and Adolescent Health
- Bacterial Infections and Vaccines
- Tuberculosis Research and Epidemiology
- Respiratory Support and Mechanisms
- Vaccine Coverage and Hesitancy
- Bacterial Identification and Susceptibility Testing
- Bartonella species infections research
- Antibiotics Pharmacokinetics and Efficacy
Bambino Gesù Children's Hospital
2015-2024
Università Cattolica del Sacro Cuore
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2011-2024
Ibero American University
2019
University of Milan
2016
University of Palermo
2016
University of Turin
2016
Ospedale Maggiore
2016
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2016
Biology of Infection
2011
Data on features of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in children and adolescents are scarce. We report preliminary results an Italian multicentre study comprising 168 laboratory-confirmed paediatric cases (median: 2.3 years, range: 1 day-17.7 55.9% males), which 67.9% were hospitalised 19.6% had comorbidities. Fever was the most common symptom, gastrointestinal manifestations frequent; two required intensive care, five seizures, 49 received experimental treatments...
Background: Many aspects of SARS-CoV-2 infection in children and adolescents remain unclear optimal treatment is debated. The objective our study was to investigate epidemiological, clinical therapeutic characteristics pediatric infection, focusing on risk factors for complicated critical disease. Methods: present multicenter Italian promoted by the Society Pediatric Infectious Diseases, involving both hospitals general pediatricians/family doctors. All subjects under 18 years age with...
As the global COVID-19 pandemic progresses, it is paramount to gain knowledge on adaptive immunity SARS-CoV-2 in children define immune correlates of protection upon immunization or infection. We analyzed anti-SARS-CoV-2 antibodies and their neutralizing activity (PRNT) 66 COVID-19-infected at 7 (±2) days after symptom onset. Individuals with specific humoral responses presented faster virus clearance lower viral load associated a reduced vitro infectivity. demonstrated that frequencies...
Acute cerebellitis (AC) and acute cerebellar ataxia (ACA) are the principal causes of dysfunction in childhood. Nevertheless. there is no accepted consensus regarding best management children with AC/ACA: aim study both to assess clinical, neuroimaging electrophysiologic features AC/ACA evaluate correlation between clinical parameters, therapy outcome. A multicentric retrospective was conducted on ≤ 18 years old admitted 12 Italian paediatric hospitals for from 01/01/2003 31/12/2013. score...
<h3>Importance</h3> Severe gastrointestinal (GI) manifestations have been sporadically reported in children with COVID-19; however, their frequency and clinical outcome are unknown. <h3>Objective</h3> To describe the clinical, radiological, histopathologic characteristics of COVID-19 presenting severe GI to identify factors associated a outcome. <h3>Design, Setting, Participants</h3> A multicenter retrospective cohort study (February 25, 2020, January 20, 2021) enrolled inpatient outpatient...
ObjectivesBecause of the spread drug-resistant Gram-positive bacteria, use linezolid for treating severe infections is increasing. However, clinical experience in paediatric population still limited. We undertook a multicentre study to analyse children.
Study on 88 adolescents with severe obesity (BMI >99°pc WHO), median age 12 ± 2 yrs, F 45%, of which 57 treated Therapeutic Education and 31 Dietotherapy. At T0: BMI 30.2 5, z score 2.98 0,4. Grade excess weight after 2.5 1.3 years in the two groups. [Tanas R Congresso Nazionale Società Italiana di Medicina dell’Adolescenza, Palermo 2012]
Monoclonal antibody therapies for COVID-19 have been frequently used in adults, whereas there are little data regarding the safety or efficacy of monoclonal treatments pediatric patients affected by COVID-19. We report our experience administration mAb as a treatment SARS-CoV-2 infection children aged from 24 days to 18 years old.
Compared to adults, severe or fatal COVID-19 disease is much less common in children. However, a higher risk for progression has been reported infants. Different pediatric severity scores are the literature. Methods: Subjects under 90 days of age admitted 35 Italian institutions were included. The was scored as mild/moderate severe/critical following classification literature by Venturini, Dong, Kanburoglu, and Gale. To assess diagnostic accuracy each system, we stratified all enrolled...
Abstract Background COVID-19 is generally milder in children than adults, however severe infection has been described some patients. Few data are available on use of Remdesivir (RDV) children, as most clinical trials focused adult We report a multicenter study conducted 10 Italian Hospitals to investigate the safety RDV affected by COVID-19. Methods collected with treated between March 2020 and February 2022 hospitals. Clinical were compared according duration therapy more or less 5 days....
The Italian Society for Pediatric Infectious Diseases created a registry on children with infective endocarditis (IE) hospitalized in Italy.A cross-sectional survey was conducted patients due to IE paediatric wards between January 1, 2000, and June 30, 2015.Over the 15-year study period, 47 episodes were observed (19 males; age range, 2-17 years). Viridans Streptococci most common pathogens among predisposing cardiac conditions Staphylococcus aureus those without (37.9% vs. 5.5%, p = 0.018,...
Objective and design Risk factors for severe measles are poorly investigated in high-income countries. The Italian Society Paediatric Infectious Diseases conducted a retrospective study children hospitalised from January 2016 to August 2017 investigate the risk outcome defined by presence of long-lasting sequelae, need intensive care or death. Results Nineteen hospitals enrolled 249 (median age 14.5 months): 207 (83%) developed complication 3 (1%) died. Neutropaenia was more commonly...
Acute/subacute haematogenous osteomyelitis (AHOM/SAHOM) are potentially devastating diseases. Updated information about the epidemiology, management and outcome of AHOM/SAHOM is needed to minimize risk complications sequelae.A multicenter study was performed evaluate retrospectively in Italy. Data from children aged >1 month, hospitalized between 2010 2016, 19 pediatric centers, were analyzed.300 with AHOM 98 SAHOM included. Median age 6.0 years (IQR: 2.0-11.0). No clinical difference...
Data on daptomycin use in the pediatric setting are scanty. We conducted a multicenter, retrospective study 46 children treated with intravenous at mean dosage of 7.0 mg/kg/d, for median 14 days. Three had adverse events possibly related to daptomycin. The drug was overall well tolerated, even prolonged treatment.
Objectives: The aim of this study is to provide new data on pediatrics spondylodiscitis for an optimal clinical management site-specific osteomyelitis. Methods: We reported 48 cases pediatric and made three comparisons between: (1) tubercular non-tubercular cases; (2) patients aged more or less than 5 years; (3) children with 62 controls non-vertebral Results: A higher rate sequelae was in spondylodiscitis, but no significant differences were noted at the cut-off years age. Compared...
Objective: The Italian Society for Pediatric Infectious Diseases created a registry to determine the management of pediatric acute mastoiditis (AM) in Italy. Methods: A cross-sectional survey paediatricians was conducted evaluate hospitalization due AM wards between 1 January 2002, and 31 December 2013. Results: total 913 children (561 males, 61.4%) were included this study. annual number cases significantly increased during study period (30 2002 98 2013) but only among older (≥4 years old;...