A5064448605- COVID-19 Clinical Research Studies
- Kawasaki Disease and Coronary Complications
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Ultrasound in Clinical Applications
- COVID-19 Impact on Reproduction
- Clostridium difficile and Clostridium perfringens research
- Bacterial Infections and Vaccines
- Nosocomial Infections in ICU
- Animal Virus Infections Studies
- Thermal Regulation in Medicine
- Streptococcal Infections and Treatments
- Antibiotic Use and Resistance
- Inflammasome and immune disorders
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Gut microbiota and health
- SARS-CoV-2 detection and testing
- HIV Research and Treatment
- Radiology practices and education
- Travel-related health issues
- COVID-19 and healthcare impacts
- Multiple Sclerosis Research Studies
- Clinical Laboratory Practices and Quality Control
- Autoimmune and Inflammatory Disorders Research
University of Turin
2020-2025
Ospedale Regina Margherita
2019-2025
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2022-2025
ASL Roma
2023
Background: Many aspects of SARS-CoV-2 infection in children and adolescents remain unclear optimal treatment is debated. The objective our study was to investigate epidemiological, clinical therapeutic characteristics pediatric infection, focusing on risk factors for complicated critical disease. Methods: present multicenter Italian promoted by the Society Pediatric Infectious Diseases, involving both hospitals general pediatricians/family doctors. All subjects under 18 years age with...
The restrictive measures adopted worldwide against SARS-CoV-2 produced a drastic reduction in respiratory pathogens, including RSV, but dramatic rebound was thereafter reported. In this multicenter retrospective observational study 15 Pediatric Emergency Departments, all children <3 years old with RSV infection admitted between 1 September and 31 December 2021 were included compared to those the same period of 2020 2019. primary aim evaluate epidemiology during after COVID-19 pandemic...
Little is known about the sequelae of SARS-CoV-2 infection in children. In a COVID-19 dedicated clinic, we followed-up for 4 months 25 children previously hospitalized COVID-19, performing clinical, laboratory, and lung ultrasound evaluation. Mid-term were rarely observed our children’s cohort.
Children with the new coronavirus disease 2019 (COVID-19) have milder symptoms and a better prognosis than adult patients. Several investigations assessed type I, II, III interferon (IFN) signatures in SARS-CoV-2 infected adults, however no data are available for pediatric TRIM28 SETDB1 regulate transcription of multiple genes involved immune response as well human endogenous retroviruses (HERVs). Exogenous viral infections can trigger activation HERVs, which turn induce inflammatory...
<h3>Importance</h3> Severe gastrointestinal (GI) manifestations have been sporadically reported in children with COVID-19; however, their frequency and clinical outcome are unknown. <h3>Objective</h3> To describe the clinical, radiological, histopathologic characteristics of COVID-19 presenting severe GI to identify factors associated a outcome. <h3>Design, Setting, Participants</h3> A multicenter retrospective cohort study (February 25, 2020, January 20, 2021) enrolled inpatient outpatient...
Severe COVID-19 and MIS-C are rare but serious outcomes associated with SARS-CoV-2 infection. The onset of often involves the gastrointestinal system, suggesting a potential connection gut microbiota. This study aims to compare microbiota children severe those using various biomolecular approaches. Gut composition specific microbial modulations were analyzed fecal samples collected at hospital admission. included hospitalized patients (mean age 6 ± 5 years) diagnosed (37 patients) or...
Bone and joint infections present a significant therapeutic challenge in children, particularly complex or chronic cases. Staphylococcus aureus is the most common causative pathogen, with methicillin resistance rates varying by geographic location hospital setting, underscoring need for antibiotics effective against both methicillin-sensitive methicillin-resistant aureus. Daptomycin, cyclic lipopeptide antibiotic gram-positive pathogens, increasingly used off-label pediatric osteomyelitis....
Background: MIS-C is a potentially severe inflammatory syndrome associated with SARS-CoV-2 exposure. Intravenous immunoglobulin (IVIG) considered the first-tier therapy, but it implies infusion of large fluid volumes that may worsen cardiac function. Patients and Methods: Since April 2020, we have developed treatment protocol avoids IVIG as first-line therapy in early phase MIS-C. In this study, retrospectively analyzed cohort consecutive patients treated according to between 01/04/2020...
Compared to adults, severe or fatal COVID-19 disease is much less common in children. However, a higher risk for progression has been reported infants. Different pediatric severity scores are the literature. Methods: Subjects under 90 days of age admitted 35 Italian institutions were included. The was scored as mild/moderate severe/critical following classification literature by Venturini, Dong, Kanburoglu, and Gale. To assess diagnostic accuracy each system, we stratified all enrolled...
A 7 years old boy with no known comorbidities was presented to our attention complaints of low-grade fever and conjunctivitis for 5 days. In the previous 48 h, he had developed gastroenteritis-like symptoms hyperpyrexia associated asthenia anorexia. The father, a medical doctor, asymptomatic, while mother, biologist, been experiencing anosmia one month. He accessed Emergency Department in April 19, 2020. His abdomen tense painful micro-petechial eruptions were obvious on his limbs. patient's...
Background: It has been suggested that children and infants can develop multisystem inflammatory syndrome in (MIS-C) response to a SARS-CoV-2 infection Black are overrepresented among cases. The aim of the current study was quantify association between Black, Asian, or other non-White genetic background COVID-19-related MIS-C infants. Methods: Eight different research groups contributed cases MIS-C, potentially related infection. Several sensitivity analyses were performed, including...
Aim: Concerns have been raised about possible neuropsychiatric sequelae of COVID-19. The objective this study was to examine the plausibility long-term mental health consequences COVID-19 by assessing a sample children after resolution acute SARS-CoV-2 infection. Method: As part systematic follow-up assessment pediatric patients with conducted at two university children’s hospitals, 50 (56% males) aged 8 17 years (median 11.5), 26% previous multisystem inflammatory syndrome in (MIS-C),...
Abstract Children with multisystem inflammatory syndrome (MIS-C) tend to develop a clinical condition of fluid overload due both contractile cardiac pump deficit and endotheliitis subsequent capillary leak syndrome. In this context, the ability point-of-care ultrasound (PoCUS) simultaneously explore multiple systems detect polyserositis could promote adequate therapeutic management balance. We describe PoCUS findings in case-series MIS-C patients admitted Emergency Department. At admission...