A5090613517- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Influenza Virus Research Studies
- Bacterial Infections and Vaccines
- Viral gastroenteritis research and epidemiology
- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Pediatric health and respiratory diseases
- Microbial infections and disease research
- Antibiotics Pharmacokinetics and Efficacy
- Infectious Diseases and Tuberculosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Orthopedic Infections and Treatments
- SARS-CoV-2 and COVID-19 Research
- Respiratory and Cough-Related Research
- Neonatal Respiratory Health Research
- HIV/AIDS Research and Interventions
- Tracheal and airway disorders
- Viral Infections and Immunology Research
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Pharmaceutical studies and practices
- Vaccine Coverage and Hesitancy
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2013-2023
University of Milan
2011-2022
Ospedale Maggiore
2006-2021
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2021
University of Turin
2016
Meyer Children's Hospital
2016
University of Florence
2016
Ospedale Regina Margherita
2016
University of Naples Federico II
2016
Istituto Giannina Gaslini
2016
Improving the quality of hospital antibiotic use is a major goal WHO's global action plan to combat antimicrobial resistance. The WHO Essential Medicines List Access, Watch, and Reserve (AWaRe) classification could facilitate simple stewardship interventions that are widely applicable globally. We aimed present data on patterns paediatric AWaRe be used for local national interventions.1-day point prevalence survey prescription were combined from two independent networks: Global Antimicrobial...
Please cite this paper as: Esposito et al. (2012) Impact of viral infections in children with community‐acquired pneumonia: results a study 17 respiratory viruses. Influenza and Other Respiratory Viruses DOI: 10.1111/j.1750‐2659.2012.00340.x. Background Little is known about the prevalence pneumonia (CAP). Objectives To describe clinical virological data collected from radiographically confirmed CAP whom viruses were sought secretion samples during acute phase disease. Patients methods The...
The spread of carbapenem-resistant Enterobacteriaceae (CRE) is a health problem major concern. CRE-related infections have significant morbidity and mortality, but data on CRE infection in pediatric population are limited. aim this study was to analyze epidemiologic clinical characteristics, risk factors, therapeutic options outcome children Italy.We performed retrospective, multicenter, observational with confirmed or colonization admitted between January 1, 2011, March 2014, 7 Italian...
Background Antimicrobials are the most commonly prescribed drugs. Many studies have evaluated antibiotic prescriptions in paediatric outpatient but few describing real consumption Italian children’s hospitals been published. Point-prevalence survey (PPS) has shown to be a simple, feasible and reliable standardized method for antimicrobials surveillance children neonates admitted hospital. In this paper, we presented data from PPS on antimicrobial carried out 7 large institutions. Methods A...
Background: The containment measures adopted during COVID-19 pandemic have influenced the epidemiology of other respiratory viruses. Aim: We analyzed modification incidence and etiology lower tract infections (LRTIs) in young children pandemic. Methods: Case series all under 2 years old hospitalized at a tertiary care Hospital Center Milan, Italy diagnosed with LRTIs three consecutive winter seasons (from 1st November to last day February 2018/2019, 2019/2020 2020/2021). compared number...
This prospective clinical and virological study of 2,060 otherwise healthy children aged <15 years age (1,112 males; mean +/- SD, 3.46 3.30 years) who attended the Emergency Department Milan University's Institute Pediatrics because an acute disease excluding trauma during winter season 2003-2004 was designed to compare prevalence importance human coronaviruses (HCoVs) in children. Real-time polymerase chain reaction (PCR) nasopharyngeal aspirates revealed HCoV infection 79 cases (3.8%): 33...
Systemic steroids have been advocated in addition to antimicrobial therapy for severe Mycoplasma pneumoniae pneumonia. We evaluated the efficacy of clarithromycin, dexamethasone, and combination M. respiratory infection.Mice infected with were treated combined clarithromycin/dexamethasone, or placebo daily; mice at baseline after 1, 3, 6 days therapy. Outcome variables included culture, lung histopathologic score (HPS), bronchoalveolar lavage cytokine, chemokine, growth factor...
To evaluate the predominant human adenovirus (HAdV) species and types associated with pediatric respiratory infections, nasopharyngeal swabs were collected from otherwise healthy children attending an emergency room in Milan, Italy, due to a tract infection January 1 February 28 of two subsequent years, 2013 2014. The HAdVs detected using virus panel fast assay (xTAG RVP FAST v2) HAdV-specific real-time polymerase chain reaction; their nucleotides sequenced, they tested for positive...
Over many years, OM-85, a lysate of 21 common bacterial respiratory pathogens, has been demonstrated to prevent recurrences in children. However, further studies are needed explore the true importance OM-85 prevention tract infections (RTIs) This study was planned contribute evaluation role played by recurrent RTIs children.This randomized (3:3:1), placebo-controlled, double-blind, single-centre, phase IV trial carried out Italy assess efficacy (Broncho-Vaxom®; Vifor Pharma; Meyrin 2/Geneva,...
Abstract This study evaluated the efficiency of pediatric mid-turbinate nasal flocked swabs used by parents in 203 children aged 6 months to 5 years with signs and symptoms respiratory disease. Two samples were collected from each child a randomised sequence: one trained pediatrician parent. The real-time polymerase chain reaction influenza virus detection rates similar using two methods (Cohen's kappa = 0.86), as cycle threshold values. In comparison pediatrician-collected samples,...
Mycoplasma pneumoniae was recently discovered to produce an ADP-ribosylating and vacuolating cytotoxin, designated CARDS toxin, which is hypothesized be a primary pathogenic mechanism responsible for M. pneumoniae-induced pulmonary inflammation. It unknown if cytotoxin production varies with strain or variation in affects disease severity.To examine the of toxin by various strains compare manifestations elicited these experimental model respiratory infection.BALB/c mice were inoculated once...
Acute cerebellitis (AC) and acute cerebellar ataxia (ACA) are the principal causes of dysfunction in childhood. Nevertheless. there is no accepted consensus regarding best management children with AC/ACA: aim study both to assess clinical, neuroimaging electrophysiologic features AC/ACA evaluate correlation between clinical parameters, therapy outcome. A multicentric retrospective was conducted on ≤ 18 years old admitted 12 Italian paediatric hospitals for from 01/01/2003 31/12/2013. score...
Methicillin-resistant Staphylococcus aureus (MRSA) is highly prevalent worldwide and can cause severe diseases. MRSA associated with other antibiotic resistance. COVID-19 pandemic increased antimicrobial resistance in adult patients. Only a few data report the susceptibility of S. Italian pediatric population, before during pandemic.We included all positive samples an available antibiogram isolated from patients (< 18 years old) tertiary care hospital Milan, Italy, January 2017 to December...
Abstract Background Medical and public health importance of pneumococcal infections justifies the implementation measures capable reducing their incidence severity, explains why recently marketed heptavalent conjugate vaccine (PCV-7) has been widely studied by pediatricians. This study was designed to evaluate impact PCV-7 administered at 3, 5 11 months age on respiratory tract in very young children. Methods A total 1,571 healthy infants (910 males) aged 75–105 days (median 82 days) were...
Although the most frequent extra-pulmonary manifestations of respiratory syncytial virus (RSV) infection involve cardiovascular system, no data regarding heart function in infants with bronchiolitis associated RSV have yet been systematically collected. The aim this study was to verify real frequency involvement patients infection, and whether mild or moderate disease also risk malfunction. A total 69 otherwise healthy aged 1-12 months hospitalised standard wards were enrolled. Pernasal...
Wheezing during early life is a very common disorder, but the reasons underlying different wheezing phenotypes are still unclear. The aims of this study were to analyse potential correlations between risk developing recurrent and presence specific polymorphisms some genes regulating immune system function, relative importance associations viruses genetic in causing episodes. involved 119 otherwise healthy infants admitted hospital for first episode (74 whom subsequently experienced episodes)...
Abstract Background The aim of this case–control study was to analyse the clinical characteristics children with recurrent community-acquired pneumonia (rCAP) affecting different lung areas (DLAs) and compare them those who have never experienced CAP in order contribute identifying best approach such patients. Methods involved 146 ≥2 episodes radiographically confirmed DLA a single year (or ≥3 any time frame) radiographic clearing densities between occurrences, 145 age- gender-matched...
In order to evaluate the adherence of healthcare providers and parents current recommendations concerning fever pain management, randomized samples 500 caring for children families were asked complete an anonymous questionnaire. The 378 health care (HCPs) responding survey (75.6%) included 144 primary pediatricians (38.1%), 98 hospital (25.9%), 62 pediatric residents (16.4%), 71 nurses (19.6%); 464 (92.8%) 175 whose youngest (or only) child was ≤5 years old (37.7%), aged 6–10 114 11–14...
This study evaluated the natural history of acute tonsillopharyngitis associated with atypical bacterial infections, showing that Mycoplasma pneumoniae and Chlamydia organisms are frequently found in children tonsillopharyngitis. The also demonstrated, for what we believe to be first time, that, unless adequately treated, infection M. C. may have a negative outcome high risk recurrence respiratory illness.