Serena Pastore
A5089277182- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Dermatology and Skin Diseases
- Osteomyelitis and Bone Disorders Research
- Orthopedic Infections and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Urticaria and Related Conditions
- Infectious Diseases and Tuberculosis
- Ocular Diseases and Behçet’s Syndrome
- Immunodeficiency and Autoimmune Disorders
- Systemic Lupus Erythematosus Research
- Adolescent and Pediatric Healthcare
- Urinary Bladder and Prostate Research
- Acute Lymphoblastic Leukemia research
- Rheumatoid Arthritis Research and Therapies
- Vasculitis and related conditions
- Immunotherapy and Immune Responses
- Kawasaki Disease and Coronary Complications
- Immune Response and Inflammation
- interferon and immune responses
- Celiac Disease Research and Management
- Pelvic floor disorders treatments
- Hematological disorders and diagnostics
- Genital Health and Disease
- Urological Disorders and Treatments
IRCCS Materno Infantile Burlo Garofolo
2016-2025
University of Rome Tor Vergata
2021-2024
Policlinico Tor Vergata
2021-2024
Aurelia Hospital
2024
University of Trieste
2010-2023
Istituti di Ricovero e Cura a Carattere Scientifico
1997-2021
Azienda Ospedaliera Universitaria Integrata Verona
2021
Bambino Gesù Children's Hospital
2018-2021
Istituto Giannina Gaslini
2017-2018
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2018
Microbial nucleic acid recognition serves as the major stimulus to an antiviral response, implying a requirement limit misrepresentation of self acids non-self and induction autoinflammation. By systematic screening using panel interferon-stimulated genes we identify two siblings singleton variably demonstrating severe neonatal anemia, membranoproliferative glomerulonephritis, liver fibrosis, deforming arthropathy increased anti-DNA antibodies. In both families biallelic mutations in DNASE2,...
Lesional skin of atopic dermatitis (AD) harbors high numbers dendritic cells with enhanced stimulatory capacity for T lymphocytes. In this study, lesional AD was shown to stain heavily in both epidermal and dermal compartments GM-CSF, a cytokine crucial cell functions. Keratinocyte cultures established from uninvolved patients exhibited markedly increased spontaneous PMA-stimulated release GM-CSF compared keratinocytes nonatopic controls. Correspondingly, showed higher constitutive as well...
Behçet's disease is a rare multi-systemic inflammatory with unknown etiology which involves principally oral and genital mucosa, skin eyes. Average age at onset of the about 25-30 years, but it may be diagnosed before 16. It not very in Italy, even though there are limited data concerning epidemiology. Aim this study to describe baseline an Italian cohort patients as having BD or probable BD. We described first national epidemiological on children coming from 16 Pediatric Rheumatologic...
Anti-TNF-α agents have significantly changed the management of juvenile idiopathic arthritis (JIA). We evaluated safety and efficacy adalimumab (ADA) infliximab (IFX) for treatment JIA-associated uveitis in patients treated ≥ 2 years.Patients with IFX ADA were managed by a standardized protocol data entered ORCHIDEA registry. At baseline, all refractory to standard immunosuppressive or corticosteroid-dependent. Data recorded every 3 months course, number/type ocular flares complications,...
Anti-transglutaminase antibodies are the diagnostic markers of coeliac disease. A role is suggested for infectious agents in production anti-transglutaminase antibodies. The aim was to measure positive antibody levels children with diseases and compare immunological biological characteristics derived from these that patients. Two hundred twenty-two suffering were enrolled prospectively along seven biopsy-proven coeliacs. Serum samples tested anti-endomysium antibodies; coeliac-related human...
Transgenic mice overexpressing PKCalpha in the epidermis (K5-PKCalpha mice) exhibit an inducible severe intraepidermal neutrophilic inflammation and systemic neutrophilia when is activated by topical 12-O-tetradecanoylphorbol-13-acetate (TPA). This model of cutaneous was used to define mediators skin that may have clinical relevance. Activation increased production chemotactic factors cytokine-induced neutrophil chemoattractant (KC) macrophage inflammatory protein 2 (MIP-2) murine plasma....
The annual incidence of ARF ranges from 5 to 51/100, 000 population worldwide in the 5- 15-year age group. In past, there was a decline ARF; however, focal outbreaks have been reported. This study evaluated 2007-08 region developed country compared with previous decade.A retrospective review all admission records for Trieste between January 2007 and December 2008 undertaken. diagnosis established by Jones criteria according 1992 revision.Between 2008: 13 cases were recorded, 11 females 2...
Background and objectives ANCA-associated vasculitis is extremely rare in children. We report the clinicopathologic features, long-term outcomes, prognostic factors of a large pediatric cohort patients with kidney vasculitis. Design, setting, participants, & measurements This retrospective study included 85 consecutive biopsy specimen–proven from tertiary referral centers Italy Canada. Kidney specimens were categorized as focal, crescentic, sclerotic, or mixed, according to Berden...
Data from routine clinical practice are needed to further define the efficacy and safety of biologic medications in children with juvenile idiopathic arthritis (JIA). The aim this analysis was investigate disease status, reasons for discontinuation adverse events Italian JIA patients treated etanercept (ETN). In 2013, all centers Pediatric Rheumatology Study Group were asked make a census given ETN after January 2000. Patients classified three groups: group 1 = still taking ETN; 2...
To study growth and puberty in a multinational longitudinal prospective cohort of children with juvenile dermatomyositis (DM).Children from 31 countries who were ages <18 years had DM active phase studied, analyses height, weight, pubertal development conducted those follow-up visits during 2-year period for whom anthropometric data was available.A total 196 275 (71%) included. We found significant reduction parent-adjusted height Z score over time female patients (P < 0.0001) male = 0.001),...
The aim of this Italian study was to describe the clinical features, treatment options and outcomes a cohort patients with chronic nonbacterial osteomyelitis (CNO).This retrospective study. Laboratory data, diagnostic imaging, histological features course are reported.We enrolled 47 diagnosed CNO. Bone pain leading symptom, multifocal disease present in 87% patients. majority bone lesions were located appendicular skeleton (58%). Extraosseous manifestations 34% patients, renal involvement...