Hamit Küçük
A5027090208- Inflammasome and immune disorders
- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Ocular Diseases and Behçet’s Syndrome
- Systemic Sclerosis and Related Diseases
- Autoimmune and Inflammatory Disorders Research
- Otitis Media and Relapsing Polychondritis
- Renal Diseases and Glomerulopathies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Retinal and Optic Conditions
- IL-33, ST2, and ILC Pathways
- Salivary Gland Disorders and Functions
- Spondyloarthritis Studies and Treatments
- Kawasaki Disease and Coronary Complications
- Inflammatory Biomarkers in Disease Prognosis
- Eosinophilic Disorders and Syndromes
- Gout, Hyperuricemia, Uric Acid
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Oral microbiology and periodontitis research
- Psoriasis: Treatment and Pathogenesis
- Inflammatory Myopathies and Dermatomyositis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Biomarkers in Disease Mechanisms
Gazi University
2016-2025
Gazi Hastanesi
2022-2024
Center for Rheumatology
2015-2024
Mardin Artuklu University
2024
Psychiatric Association of Turkey
2024
Ankara Yıldırım Beyazıt University
2020-2022
Bağcılar Eğitim ve Araştırma Hastanesi
2022
Nature Conservation Centre
2021
Erzurum Regional Training and Research Hospital
2018-2019
Sağlık Bilimleri Üniversitesi
2018
Blood neutrophil-to-lymphocyte (N/L) ratio is an indicator of the overall inflammatory status body, and alteration in N/L may be found ulcerative colitis (UC) patients. The aims this study were to investigate utility as a simple readily available predictor for clinical disease activity UC.Twenty-six patients 28 healthy controls enrolled study. neutrophil lymphocyte counts recorded, was calculated from these parameters. extent classified according Montreal classification, evaluated using...
Background: Colchicine is the mainstay of treatment familial Mediterranean fever (FMF). However, 10% FMF patients do not respond well to colchicine. Efficacy interleukin (IL)-1 inhibitors in reducing attacks have been demonstrated colchicine-resistant (crFMF) recently. still only approved drug for prevention amyloidosis and utility IL-1 crFMF cases who already has remain be elucidated. Herein, we evaluated efficacy safety with crFMF-associated AA a relatively large single center study....
Background: Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse systemic manifestations, including neuropsychiatric involvement (NPSLE), which can vary in severity and prognosis. Diagnosing NPSLE remains challenging, necessitating reliable diagnostic markers. CXCL13, a B-cell chemokine implicated SLE, has garnered attention for its potential role NPSLE. Purpose: This study aimed to assess serum CXCL-13 levels patients compared SLE without symptoms healthy controls....
During the last decade, spondyloarthritis (SpA) has increasingly been considered a disease at crossroads between autoimmunity and autoinflammation. Some patients may even present with autoinflammatory-related manifestations, including fever, hidradenitis suppurativa, other neutrophilic dermatoses, an unusually high increase in inflammatory markers. Therefore, subgroup of SpA be identified, specific details about this cluster need to investigated. In regard, AutoInflammatory Disease Alliance...
VEXAS syndrome, a recently identified systemic autoinflammatory disorder, poses new diagnostic and management challenges. Based on experience with other diseases, anti-interleukin (IL)-1, anti-IL-6, anti-tumor necrosis factor (TNF) biotechnological agents, Janus kinase inhibitors (JAKis) have been widely employed in patients. The aim of this study is to evaluate the global effectiveness safety agents JAKis using data from real-world context. Clinical, laboratory, therapeutic patients were...
Summary Background Systemic lupus erythematosus is a multisystem autoimmune disease primarily manifesting as nephritis. While nephritis the most common renal pathology in lupus, non-lupus nephropathies such IgA nephropathy occasionally occur. This study aims to evaluate clinical features and outcomes of patients with nephropathy, comparing them those primary Methods A comprehensive literature review was conducted using PubMed Google Scholar databases identify cases systemic reported between...
Lungs are among the most affected organs in systemic sclerosis (SSc), with interstitial lung disease (ILD) being a leading cause of mortality. Biomarkers increasingly explored for predicting SSc-ILD detection and progression. This study evaluates roles Krebs von den Lungen-6 (KL-6), surfactant protein D (SP-D), peroxiredoxin-4 (PRDX-4) diagnosing monitoring A total 89 individuals (61 SSc patients 28 healthy volunteers) were included. grouped based on pulmonary function tests high-resolution...
Proteinuria, amyloidosis, and kidney failure are the main long-term renal complications of familial Mediterranean fever (FMF). This study assesses their risk factors, independent ethnicity or residence. Patients' data were drawn from International AIDA Network registry for monogenic autoinflammatory diseases. A total 598 FMF patients enrolled, with 80 having proteinuria, 61 25 failure. At multivariate regression analysis, proteinuria was associated out-of-flares thrombocytosis (OR: 4.78,...
To investigate the prevalence of pulmonary arterial hypertension (PAH) and possible contributing factors for PAH in patients receiving regular continuous ambulatory peritoneal dialysis (CAPD).The study included 135 CAPD 15 disease-free controls. Patients that had chronic obstructive disease, severe mitral or aortic valve connective tissue history embolism, left ventricular ejection fraction <50%, chest wall parenchymal lung disease were excluded. All controls examined using echocardiography...
To investigate the effectiveness of 2-dimensional shear wave elastography (2D-SWE) in assessment lacrimal gland involvement primary Sjögren's syndrome (pSS) and to determine association between ultrasonographic findings clinical activity measures.Forty-six patients who fulfilled 2016 American College Rheumatology/European League Against Rheumatism (EULAR) classification criteria pSS 23 age gender-matched healthy control subjects were enrolled. Clinical, laboratory labial biopsy...
Still's disease is more frequently observed in the paediatric context, but a delayed onset not exceptional both adulthood and elderly. However, whether paediatric-onset, adult-onset elderly-onset represent expressions of same continuum or different clinical entities still matter controversy. The aim this study to search for any differences demographic, features response treatment between pediatric-onset, disease.Subjects included were drawn from International AutoInflammatory Disease...
Abstract Purpose of the present paper is to point out design, development and deployment AutoInflammatory Disease Alliance (AIDA) International Registry dedicated pediatric adult patients with Behçet’s disease (BD). The a clinical physician-driven non-population- electronic-based instrument implemented for retrospective prospective collection real-life data about demographics, clinical, therapeutic, laboratory, instrumental socioeconomic information from BD patients; based on Research...
Biomarkers of lung injury and interstitial fibrosis give insight about the extent involvement prognosis in well-known diseases (ILD). Serum Krebs von den Lungen-6 (KL-6) reflects direct alveolar and, transforming growth factor-beta1 (TGF-β1) fibroblast factor-2 (FGF-2) are principal mediators ILD almost all fibrotic diseases. In this sense, we aimed to assess associations these biomarkers with traditional inflammatory markers clinical course COVID-19.Patients COVID-19 who had confirmed...
Objective Inflammation has been associated with an increased risk for cancer development, while innate immune system activation could counteract the malignancies. Familial Mediterranean fever (FMF) is a severe systemic inflammatory condition and also represents archetype of immunity deregulation. Therefore, aim this study to investigate development in FMF. Methods The ratio (RR) malignancies was separately compared between FMF patients fibromyalgia subjects, Still’s disease Behçet’s...
In the case of high erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels, diagnosis underlying disease can be challenging especially in serologically unrevealing patients who have nonspecific clinical findings. We aimed to investigate final distribution definitive diagnoses initially presented with findings sustained elevations serum ESR/CRP levels.The medical records hospitalized a rheumatology clinic between January 2010 2011 were retrospectively analyzed. The...
This study was designed to investigate the relationship between kinesiophobia and level of physical activity, depression, disease fatigue, pain, quality life in female patients with systemic lupus erythematosus (SLE).
Background: Chronic inflammation, as determined by persistently elevated acute-phase reactants in attack-free periods, can occasionally be observed patients with familial Mediterranean fever (FMF) and is suggested to a risk factor for the development of amyloidosis. We aimed investigate underlying causes chronic inflammation FMF its association amyloidosis long-term follow-up.Method: Electronic medical records who had regular follow-up ≥ 5 years our cohort were utilized. As part routine...
Granulomatosis with polyangiitis (GPA) is a rare necrotizing vasculitis, which usually involves the upper and lower respiratory systems kidneys often have relapsing course. Neutrophil/lymphocyte ratio (NLR) has been shown to be useful marker predicting not only progressive disease, but also mortality in various inflammatory diseases. We aimed investigate roles of NLR extend clinical involvement prognosis patients GPA.Consecutive newly diagnosed GPA who had follow-up for at least 6 months...
The present manuscript aims to describe an international, electronic-based, user-friendly and interoperable patient registry for monogenic autoinflammatory diseases (mAIDs), developed in the contest of Autoinflammatory Diseases Alliance (AIDA) Network.This is electronic platform, based on Research Electronic Data Capture (REDCap) tool, used real-world data collection demographics, clinical, laboratory, instrumental socioeconomic mAIDs patients. instrument has flexibility, may change over...