A5011026117- Inflammasome and immune disorders
- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Osteoarthritis Treatment and Mechanisms
- Vasculitis and related conditions
- Autoimmune and Inflammatory Disorders Research
- Nutrition and Health in Aging
- Systemic Sclerosis and Related Diseases
- Ocular Diseases and Behçet’s Syndrome
- Spondyloarthritis Studies and Treatments
- Salivary Gland Disorders and Functions
- interferon and immune responses
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hip disorders and treatments
- IL-33, ST2, and ILC Pathways
- Gout, Hyperuricemia, Uric Acid
- Bone and Joint Diseases
- Frailty in Older Adults
- Inflammatory Biomarkers in Disease Prognosis
- Inflammatory mediators and NSAID effects
- Lower Extremity Biomechanics and Pathologies
- Kawasaki Disease and Coronary Complications
- Total Knee Arthroplasty Outcomes
- Musculoskeletal synovial abnormalities and treatments
- Psoriasis: Treatment and Pathogenesis
Gazi University
2016-2025
Center for Rheumatology
2008-2024
Samsun University
2021
British Geriatrics Society
2018-2020
Gazi Hastanesi
2019-2020
Turkish Thoracic Society
2014
Weatherford College
2009
Istanbul University
2008
University of Liège
2006
Rush University Medical Center
1999-2005
Elevated neutrophil count is associated with poor prognosis and increased mortality in many conditions. Neutrophil to lymphocyte ratio (NLR) has emerged as a marker of inflammation neoplastic cardiovascular disorders. Herein, we investigated utility this simple tool rheumatoid arthritis (RA) ankylosing spondylitis (AS).The study consisted 136 RA 140 AS patients, along 117 healthy control subjects. activities were determined Disease Activity Score (DAS) Bath Ankylosing Spondylitis indices...
Background: Colchicine is the mainstay of treatment familial Mediterranean fever (FMF). However, 10% FMF patients do not respond well to colchicine. Efficacy interleukin (IL)-1 inhibitors in reducing attacks have been demonstrated colchicine-resistant (crFMF) recently. still only approved drug for prevention amyloidosis and utility IL-1 crFMF cases who already has remain be elucidated. Herein, we evaluated efficacy safety with crFMF-associated AA a relatively large single center study....
Objective To investigate the role of circulating hepcidin, which is a homeostatic regulator iron metabolism and mediator inflammation, in anemia associated with rheumatoid arthritis. Methods Forty patients arthritis (19 21 without anemia), 12 deficiency 14 healthy adults were studied. Serum hepcidin levels analyzed prohormone solid phase enzyme-linked immunosorbent assay. Results The mean serum significantly higher compared to those anemia. active group had than inactive group. In group,...
Abstract Objective The aim of the present study was to investigate prevalence and pattern cognitive dysfunction observed in primary Sjögren's syndrome (PSS) examine relationships between abilities, depression, fatigue, quality life. Materials Methods Thirty‐two subjects with PSS were compared 19 healthy controls on comprehensive neuropsychological, health state, daily‐life activities tests. Results There low performance Clock Drawing, COWAT, Paced Auditory Serial Addition Test (PASAT),...
Background: Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse systemic manifestations, including neuropsychiatric involvement (NPSLE), which can vary in severity and prognosis. Diagnosing NPSLE remains challenging, necessitating reliable diagnostic markers. CXCL13, a B-cell chemokine implicated SLE, has garnered attention for its potential role NPSLE. Purpose: This study aimed to assess serum CXCL-13 levels patients compared SLE without symptoms healthy controls....
Summary Background Systemic lupus erythematosus is a multisystem autoimmune disease primarily manifesting as nephritis. While nephritis the most common renal pathology in lupus, non-lupus nephropathies such IgA nephropathy occasionally occur. This study aims to evaluate clinical features and outcomes of patients with nephropathy, comparing them those primary Methods A comprehensive literature review was conducted using PubMed Google Scholar databases identify cases systemic reported between...
Lungs are among the most affected organs in systemic sclerosis (SSc), with interstitial lung disease (ILD) being a leading cause of mortality. Biomarkers increasingly explored for predicting SSc-ILD detection and progression. This study evaluates roles Krebs von den Lungen-6 (KL-6), surfactant protein D (SP-D), peroxiredoxin-4 (PRDX-4) diagnosing monitoring A total 89 individuals (61 SSc patients 28 healthy volunteers) were included. grouped based on pulmonary function tests high-resolution...
Background Patient-reported outcomes in lupus nephritis (LN) are not well studied. Studies with disease-targeted PRO tool LN do exist. Herein, we describe quality of life (QOL: HRQOL & non-HRQOL) among patients using LupusPRO. Methods International, cross-sectional data from 1259 systemic erythematosus (SLE) and LupusPRO were compared, stratified by (a) presence (ACR classification criteria (ACR-LN)) at any time and, (b) active (on SLEDAI) study visit. Damage was assessed SLICC/ACR-SDI....
To investigate the effectiveness of 2-dimensional shear wave elastography (2D-SWE) in assessment lacrimal gland involvement primary Sjögren's syndrome (pSS) and to determine association between ultrasonographic findings clinical activity measures.Forty-six patients who fulfilled 2016 American College Rheumatology/European League Against Rheumatism (EULAR) classification criteria pSS 23 age gender-matched healthy control subjects were enrolled. Clinical, laboratory labial biopsy...
Persistent inflammation is an insidious and less studied feature of FMF. We investigated clinical determinants persistent its associations with individual damage items.This a cross-sectional analysis 917 FMF patients, who fulfilled the Tel Hashomer criteria had at least 6 months' follow-up. Patients were stratified based on whether they inflammation. used logistic regression to investigate independent predictors associated items.One hundred forty-two (15%) patients Active (54%) was most...
The rate of progressive joint space narrowing in the contralateral hip after total arthroplasty (THA) for osteoarthritis (OA) and factors which may predispose patients to more aggressive remain undefined. current study sought evaluate pattern of, risk for, THA OA.Each patient who underwent OA 1984-1985 was followed up longitudinally, annual anteroposterior (AP) pelvis radiographs were obtained. radiographic width (JSW) each quantified, rates JSW determined. Evaluation potential accelerated...
In the case of high erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels, diagnosis underlying disease can be challenging especially in serologically unrevealing patients who have nonspecific clinical findings. We aimed to investigate final distribution definitive diagnoses initially presented with findings sustained elevations serum ESR/CRP levels.The medical records hospitalized a rheumatology clinic between January 2010 2011 were retrospectively analyzed. The...
Background: Chronic inflammation, as determined by persistently elevated acute-phase reactants in attack-free periods, can occasionally be observed patients with familial Mediterranean fever (FMF) and is suggested to a risk factor for the development of amyloidosis. We aimed investigate underlying causes chronic inflammation FMF its association amyloidosis long-term follow-up.Method: Electronic medical records who had regular follow-up ≥ 5 years our cohort were utilized. As part routine...