Moustafa Ali Saad
A5010331698- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Systemic Lupus Erythematosus Research
- Adolescent and Pediatric Healthcare
- Ocular Diseases and Behçet’s Syndrome
- Osteomyelitis and Bone Disorders Research
- Phagocytosis and Immune Regulation
- Infective Endocarditis Diagnosis and Management
- Extracellular vesicles in disease
- Ferroptosis and cancer prognosis
- Kawasaki Disease and Coronary Complications
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Otitis Media and Relapsing Polychondritis
- Neuroendocrine Tumor Research Advances
- Mycobacterium research and diagnosis
- IL-33, ST2, and ILC Pathways
- Pulmonary Hypertension Research and Treatments
- Parasitic infections in humans and animals
- IgG4-Related and Inflammatory Diseases
- Vascular Malformations and Hemangiomas
- interferon and immune responses
- Congenital Anomalies and Fetal Surgery
Cairo University
2022-2025
Proteinuria, amyloidosis, and kidney failure are the main long-term renal complications of familial Mediterranean fever (FMF). This study assesses their risk factors, independent ethnicity or residence. Patients' data were drawn from International AIDA Network registry for monogenic autoinflammatory diseases. A total 598 FMF patients enrolled, with 80 having proteinuria, 61 25 failure. At multivariate regression analysis, proteinuria was associated out-of-flares thrombocytosis (OR: 4.78,...
Objective Inflammation has been associated with an increased risk for cancer development, while innate immune system activation could counteract the malignancies. Familial Mediterranean fever (FMF) is a severe systemic inflammatory condition and also represents archetype of immunity deregulation. Therefore, aim this study to investigate development in FMF. Methods The ratio (RR) malignancies was separately compared between FMF patients fibromyalgia subjects, Still’s disease Behçet’s...
Objective This paper points out the design, development and deployment of AutoInflammatory Disease Alliance (AIDA) International Registry dedicated to pediatric adult patients affected by Undifferentiated Systemic Diseases (USAIDs). Methods is an electronic registry employed for real-world data collection about demographics, clinical, laboratory, instrumental socioeconomic USAIDs patients. Data recruitment, based on Research Electronic Capture (REDCap) tool, designed obtain standardized...
To characterize clinical and laboratory signs of patients with Still's disease experiencing macrophage activation syndrome (MAS) identify factors associated MAS development. Patients classified according to internationally accepted criteria were enrolled in the AutoInflammatory Disease Alliance (AIDA) Registry. Clinical features observed during inflammatory attack complicated by included univariate multivariate logistic regression analysis A total 414 included; 39 (9.4%) them developed...
The present paper describes the design, development, and implementation of AutoInflammatory Disease Alliance (AIDA) International Registry specifically dedicated to patients with Schnitzler's syndrome.This is a clinical physician-driven, population- electronic-based registry implemented for retrospective prospective collection real-life data from syndrome; based on Research Electronic Data Capture (REDCap) tool, which designed collect standardized information research, has been realized...
Abstract Background Pulmonary hydatidosis is a zoonotic infection caused by the tapeworm of genus Echinococcus. Case presentation In this case report we present 38-year-old woman presenting with hemoptysis as manifestation pulmonary hydatidosis. Hemoptysis was falsely interpreted at first hematemesis leading to multiple non-indicated gastroscopies. The patient diagnosed pathological examination lobectomy sample. Conclusions Proper history, in differentiating from hematemesis, guides proper...
Abstract Background Behcet's syndrome (BS) is a variable-vessel vasculitis characterized by hyperactive innate immunity. The nuclear factor kappa B (NFKB) pathway involved in the regulation of inflammatory responses including and adaptive immune responses. BS could be associated with NFKB hyperactivation. We aimed to study association between NFKB1 A > G (rs4648068) single-nucleotide polymorphism (SNP) Egyptian patients, comparison healthy controls, correlate presence rs4648068 SNP...
Abstract Background Systemic lupus erythematosus is a chronic multisystem disease that has considerable morbidity and mortality. Rituximab used in treating some severe manifestations of systemic erythematosus; however, it may expose patients to serious infections. We report case post rituximab infective endocarditis as the second literature described with SLE. Case presentation A 17-year-old male diagnosed nephritis dilated cardiomyopathy received underwent upper endoscopy colonoscopy...