Piero Ruscitti
A5030868203- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Systemic Sclerosis and Related Diseases
- Inflammasome and immune disorders
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Spondyloarthritis Studies and Treatments
- Kawasaki Disease and Coronary Complications
- Psoriasis: Treatment and Pathogenesis
- Adolescent and Pediatric Healthcare
- Salivary Gland Disorders and Functions
- Connective Tissue Growth Factor Research
- Otitis Media and Relapsing Polychondritis
- Chronic Lymphocytic Leukemia Research
- Family and Disability Support Research
- Dermatologic Treatments and Research
- Salivary Gland Tumors Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Long-Term Effects of COVID-19
- Cytokine Signaling Pathways and Interactions
- Peripheral Neuropathies and Disorders
- Acute Lymphoblastic Leukemia research
- Ocular Diseases and Behçet’s Syndrome
- COVID-19 Clinical Research Studies
- Bone and Joint Diseases
University of L'Aquila
2016-2025
Health First
2024
University of Siena
2021
Center for Rheumatology
2021
Vita-Salute San Raffaele University
2021
Istituti di Ricovero e Cura a Carattere Scientifico
2021
San Salvatore Hospital
2016-2021
University of Bari Aldo Moro
2018-2021
University of Campania "Luigi Vanvitelli"
2018-2021
Sapienza University of Rome
2021
Objective Postacute COVID-19 syndrome (PACS) is an emerging entity characterised by a large array of manifestations, including musculoskeletal complaints, fatigue and cognitive or sleep disturbances. Since similar symptoms are present also in patients with fibromyalgia (FM), we decided to perform web-based cross-sectional survey aimed at investigating the prevalence predictors FM who recovered from COVID-19. Methods Data were anonymously collected between 5 18 April 2021. The collection form...
<h3>Background</h3> The transition from psoriasis (PsO) to psoriatic arthritis (PsA) and the early diagnosis of PsA is considerable scientific clinical interest for prevention interception PsA. <h3>Objective</h3> To formulate EULAR points consider (PtC) development data-driven guidance consensus trials practice in field or management people with PsO at risk development. <h3>Methods</h3> A multidisciplinary task force 30 members 13 European countries was established, standardised operating...
Systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD) are considered the same disease, but a common approach for diagnosis management is still missing. In May 2022, EULAR PReS endorsed proposal joint task force (TF) to develop recommendations of sJIA AOSD. The TF agreed during first meeting address four topics: similarity between AOSD, diagnostic biomarkers, therapeutic targets strategies complications including macrophage activation syndrome (MAS). Systematic...
Abstract Introduction Primary Sjögren’s syndrome (pSS) is an autoimmune disorder affecting exocrine glands; however, a subgroup of pSS patients experience systemic extra-glandular involvement leading to worsening disease prognosis. Current therapeutic options are mainly empiric and often translated by other diseases. In the last few years growing evidence suggests that B-cell depletion rituximab (RTX) effective also in pSS. Patients with early active appear be those who could benefit most...
Adult-onset Still’s disease (AOSD) is rare inflammatory of unknown etiology that usually affects young adults. The more common clinical manifestations are spiking fevers, arthritis, evanescent rash, elevated liver enzymes, lymphadenopathy, hepatosplenomegaly, and serositis. multi-visceral involvement the different complications, such as macrophage activation syndrome, may strongly decrease life expectancy AOSD patients. This study aimed to identify positive negative features correlated with...
Background The inflammatory contribution to type 2 diabetes (T2D) has suggested new therapeutic targets using biologic drugs designed for rheumatoid arthritis (RA). On this basis, we aimed at investigating whether interleukin-1 (IL-1) inhibition with anakinra, a recombinant human IL-1 receptor antagonist, could improve both glycaemic and parameters in participants RA T2D compared tumour necrosis factor (TNF) inhibitors (TNFis). Methods findings This study, as multicentre, open-label,...
A better understanding about the mechanisms involved in pathogenesis of type 2 diabetes mellitus (T2D) showed that inflammatory cytokines such as tumour necrosis factor (TNF) and interleukin (IL)-1β play a pivotal role, mirroring data largely reported rheumatoid arthritis (RA). IL-1β is produced mainly by monocytes (MO), hyperglycaemia may be able to modulate, cytoplasm these cells, assembly nucleotide-binding domain leucine-rich repeat containing family pyrin (NLRP3)-inflammosome, cytosolic...
Objectives To explore the relevance of T-follicular-helper (Tfh) and pathogenic peripheral-helper T-cells (Tph) in promoting ectopic lymphoid structures (ELS) B-cell mucosa-associated tissue (MALT) lymphomas (MALT-L) Sjögren’s syndrome (SS) patients. Methods Salivary gland (SG) biopsies with matched peripheral blood were collected from four centres across European Union. Transcriptomic (microarray quantitative PCR) analysis, FACS T-cell immunophenotyping intracellular cytokine detection,...
Background: Interleukin (IL)-1 plays a crucial role in the pathogenesis of Adult onset Still's disease (AOSD). Objectives: To evaluate efficacy and safety anakinra (ANA) canakinumab (CAN) large group AOSD patients. Methods: Data on clinical, serological features, concomitant treatments were retrospectively collected at baseline after 3, 6, 12 months from patients (Yamaguchi criteria) referred by 18 Italian centers. Pouchot's score was used to severity. Results: One hundred forty treated with...
Objective. High endothelin-1 (ET-1) and transforming growth factor-β (TGF-β) levels may induce in healthy endothelial cells (EC) an endothelial-to-mesenchymal transition (EndMT). The same cytokines are associated with fibrosis development systemic sclerosis (SSc). Although EndMT has not been definitively shown SSc, this process, potentially induced by a stimulatory loop involving these 2 cytokines, overexpressed disease might contribute to fibroblast accumulation affected tissues. Macitentan...
To better define the spectrum of new-onset post-COVID-19 and vaccine inflammatory rheumatic diseases (IRD) from a large multicentric observational study.Consecutive cases IRD encountered during 12-month period satisfying one following inclusion criteria: (a) onset manifestations within 4 weeks SARS-CoV-2 infection or (b) administration COVID-19 vaccines ws recruited.The final analysis cohort comprised 267 patients, which 122 (45.2%) in 145 (54.8%) postvaccine cohort. Distribution categories...
VEXAS syndrome is a recently described monogenic autoinflammatory disease capable of manifesting itself with wide array organs and tissues involvement. Orbital/ocular inflammatory manifestations are frequently in patients. The objective this study to further describe orbital/ocular conditions while investigating potential associations other manifestations. In the present study, twenty-seven out 59 (45.8%) patients showed an involvement during their clinical history. most frequent affections...