A5046968872- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Otitis Media and Relapsing Polychondritis
- Mitochondrial Function and Pathology
- Bone health and treatments
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Family and Disability Support Research
- Probiotics and Fermented Foods
- Bone health and osteoporosis research
- Milk Quality and Mastitis in Dairy Cows
- Monoclonal and Polyclonal Antibodies Research
- Neurological and metabolic disorders
- Vitamin D Research Studies
- Biosimilars and Bioanalytical Methods
- ATP Synthase and ATPases Research
- Cardiac Ischemia and Reperfusion
- Kawasaki Disease and Coronary Complications
- Spondyloarthritis Studies and Treatments
- Identification and Quantification in Food
- Chronic Lymphocytic Leukemia Research
- Bone Metabolism and Diseases
- Advanced Chemical Sensor Technologies
- Cancer, Hypoxia, and Metabolism
- Muscle and Compartmental Disorders
University of Padua
2023-2024
University of Verona
2012-2020
Azienda Ospedaliera Universitaria Integrata Verona
2019
Società Italiana di Reumatologia
2017
The coronavirus disease 2019 (COVID-19) pandemic is threatening billions of people worldwide. Tocilizumab has shown promising results in retrospective studies patients with COVID-19 pneumonia a good safety profile.To evaluate the effect early tocilizumab administration vs standard therapy preventing clinical worsening hospitalized pneumonia.Prospective, open-label, randomized trial that between March 31 and June 11, 2020, to receive or care 24 hospitals Italy. Cases were confirmed by...
Background: Interleukin (IL)-1 plays a crucial role in the pathogenesis of Adult onset Still's disease (AOSD). Objectives: To evaluate efficacy and safety anakinra (ANA) canakinumab (CAN) large group AOSD patients. Methods: Data on clinical, serological features, concomitant treatments were retrospectively collected at baseline after 3, 6, 12 months from patients (Yamaguchi criteria) referred by 18 Italian centers. Pouchot's score was used to severity. Results: One hundred forty treated with...
The evolving field of food technology is increasingly dedicated to developing functional foods. This study explored bioactive peptides from sunflower protein isolate (SPI), obtained defatted flour, a by-product the oil processing industry. SPI underwent simulated gastrointestinal digestion and peptide-enriched fraction (PEF) showed antioxidant properties in vivo, zebrafish. Among present PEF identified by mass spectrometry analysis, we selected those with silico evaluation, considering their...
Abstract MitoK ATP is a channel of the inner mitochondrial membrane that controls K + influx according to availability. Recently, genes encoding pore-forming (MITOK) and regulatory ATP-sensitive (MITOSUR) subunits mitoK were identified, allowing genetic manipulation channel. Here, we analyzed role in determining skeletal muscle structure activity. Mitok −/− muscles characterized by cristae remodeling defective oxidative metabolism, with consequent impairment exercise performance altered...
Osteoporosis and fractures are common invalidating consequences of chronic glucorticoid (GC) treatment. Reliable information regarding the epidemiology GC induced osteoporosis (GIOP) comes exclusively from placebo group randomized clinical trials while observational studies generally lacking data on real prevalence vertebral fractures, dosage primary diagnosis. The objective this study was to evaluate incidence osteoporotic identify their major determinants (primary disease, dosage, bone...
Background: Anakinra (ANA) is an effective treatment choice in patients with adult onset Still's disease (AOSD). Variables affecting survival include loss of efficacy or adverse events, but also the decision to discontinue after long-term clinical remission. Objectives: Aims this study were: (i) assess drug retention rate (DRR) ANA during a follow-up looking for any difference related line biologic treatment, concomitant use conventional modifying anti-rheumatic drugs (cDMARDs) and different...
Abstract Obesity is associated with increased risk and worse prognosis of many tumours including those the breast esophagus. Adipokines released from peritumoural adipose tissue promote metastatic potential cancer cells, suggesting existence a crosstalk between surrounding tumour. Mitochondrial Ca 2+ signaling contributes to progression carcinoma different origins. However, whether adipocyte-derived factors modulate mitochondrial in unknown. Here, we show that conditioned media derived...
Background: Aim of this study was to search for any difference in the outcome patients with adult onset Still's disease (AOSD) treated anakinra (ANA) relationship delay between and start anti-IL (interleukin)-1 treatment according different lines ANA treatment. Patients Methods: One hundred forty-one AOSD have been retrospectively assessed. Statistically significant differences (p<0.05) were analyzed frequency efficacy, primary or secondary inefficacy rate resolution clinical laboratory...
Methode impedimetrique pour le denombrement selectif de la flore specifique du yaourt en utilisant des milieux culture a base lait. La validite methode l'impedance microbien yaourt, Streptococcus thermophilus et Lactobacillus delbrueckii subsp bulgaricus, ete comparee avec determination microorganismes realisee par traditionnelle numeration boites Petri. Plusieurs echantillons ont analyses appliquant les nouveaux selectifs lait (lait sucre acidifie) ce qui concerne utilisant, parallelement,...
<h3>Background</h3> Adult onset Still9s disease (AOSD) is a rare rheumatic with an estimated prevalence of less than 1 case per 100,000 population. The diagnosis difficult and often delayed due to the lack specific diagnostic tests need rule out other pathological entities. <h3>Objectives</h3> To describe clinical characteristics multicenter Italian series patients AOSD. <h3>Methods</h3> 14 University Hospital centers participated in study. A standardized medical record containing data,...
<h3>Background</h3> The strategy for the choice of second biologic agent after failure first TNF inhibitor (TNFi) is still an unclear aspect in treatment both rheumatoid arthritis (RA) and psoriatic (PsA). Switching between structurally different TNFis (from etanercept [ETN] to monoclonal antibody [mAb] or vice versa) has been proposed as a more effective procedure than switching among mAbs, but date no study specifically focused on exploring this topic. <h3>Objectives</h3> To evaluate...