A5102847051- SARS-CoV-2 and COVID-19 Research
- Inflammasome and immune disorders
- COVID-19 Clinical Research Studies
- Gut microbiota and health
- Pericarditis and Cardiac Tamponade
- Autoimmune and Inflammatory Disorders Research
- Otitis Media and Relapsing Polychondritis
- Infective Endocarditis Diagnosis and Management
- Family and Disability Support Research
- Streptococcal Infections and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Neurological Complications and Syndromes
- Myasthenia Gravis and Thymoma
- Studies on Chitinases and Chitosanases
- Vasculitis and related conditions
- Congenital Diaphragmatic Hernia Studies
- Gout, Hyperuricemia, Uric Acid
- Respiratory and Cough-Related Research
- Liver Diseases and Immunity
- Lysosomal Storage Disorders Research
- Obesity and Health Practices
- Atrial Fibrillation Management and Outcomes
- interferon and immune responses
- Otolaryngology and Infectious Diseases
- Tryptophan and brain disorders
Università Cattolica del Sacro Cuore
2019-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2023
Agostino Gemelli University Polyclinic
2020-2023
Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari
2022
Boston University
2020
Background: Anakinra (ANA) is an effective treatment choice in patients with adult onset Still's disease (AOSD). Variables affecting survival include loss of efficacy or adverse events, but also the decision to discontinue after long-term clinical remission. Objectives: Aims this study were: (i) assess drug retention rate (DRR) ANA during a follow-up looking for any difference related line biologic treatment, concomitant use conventional modifying anti-rheumatic drugs (cDMARDs) and different...
All-cause mortality related to the SARS-CoV-2 infection has declined from first wave subsequent waves, probably through vaccination programs and availability of effective antiviral therapies. Our study aimed evaluate impact on prognosis infected patients. Overall, we enrolled 545 subjects during Delta variant 276 ones Omicron wave. Data were collected concerning status, clinical parameters, comorbidities, lung involvement, laboratory pharmacological treatment. Outcomes admission intensive...
Sarcoidosis is a multi-organ inflammatory granulomatosis with lung-predominant involvement. The aim of this study was to investigate the use serum chitotriosidase (CHIT1) in patients fever unknown origin (FUO); confirmed diagnosis active sarcoidosis were compared ones affected by inactive or treated sarcoidosis. CHIT1 activity evaluated 110 initially admitted at hospital as FUOs. overall performance for assessed performing an area under receiver operating characteristic curve analysis...
Odontogenic infections represent a frequent condition that in some cases, if not treated promptly, can spread quickly to the rest of body and turn into life-threatening infections. In this work, case is reported 59-year-old woman, diabetic overweight, who presented Odontostomatology Otolaryngology Section Policlinic Bari with mandibular tooth infection had developed deep neck space leading involvement cavernous sinuses near mediastinum. The diagnosis, surgical drainage phlegmon removal foci,...
Remdesivir (RDV) has demonstrated clinical benefit in hospitalized COronaVIrus Disease (COVID)-19 patients. The objective of this brief report was to assess a possible correlation between RDV therapy and the variation lymphocyte subpopulations. We retrospectively studied 43 COVID-19 patients: 30 men 13 women (mean age 69.3 ± 15 years); 9/43 had received therapy. Six patients no need for oxygen (severity group 0); 22 were on treatment with fraction inspired (FiO2) ≤ 50% (group 1); 7...
A 44-year-old Jewish woman with familial Mediterranean fever (FMF) developed non-alcoholic steato-hepatitis during colchicine treatment (2,5 mg per day), confirmed by both elastographic study and liver biopsy. combined therapy the interleukin-1 (IL-1) blocking agent canakinumab (150 every 4 weeks) (at a reduced dose of 1.5 day) was started. Three months later transaminases became normal, six there marked improvement fibrosis on study. Hepatic involvement in FMF occurs ranging from...
Diseases of the pericardium encompass a spectrum conditions, including acute and recurrent pericarditis, where inflammation plays pivotal role in pathogenesis clinical manifestations. Anti-inflammatory therapy indeed forms cornerstone treating these conditions: NSAIDs, colchicine, corticosteroids (as second-line treatment) are recommended by current guidelines. However, medications come with several contraindications not devoid adverse effects. In recent years, there has been an increased...
Background Acute pericarditis represents an inflammatory disease affecting the pericardial layers. In developed countries more than 80% of are defined as idiopathic, less frequently they secondary to other conditions such infections, rheumatic or systemic diseases, cancer, post–cardiac injury syndromes and radiation therapy (RT). Case presentation We reported a case patient with acute that occurred few hours after chest therapy, performed for breast cancer. After failure first-line we...
Introduction: Recently, medical interest has been growing in SARS-CoV-2 infection and its multiorgan involvement, including the liver. Up until now, a few reports have described autoimmune hepatitis (AIH) triggered by infection, but no data are available about specific liver inflammatory infiltrate cluster of differentiation. We report case AIH with particular focus on histological mainly immunohistochemical features. Case description: A 60-year-old man, history paucisymptomatic that...
Background: Evidence has linked pre and postnatal air pollution exposure with children's weight; however, studies assessing the effects on growth trajectories are lacking not consistent. We investigated role of time-varying 90 days average spatio-temporal fine particulate matter (PM2.5) as an effect modifier sex-specific in early childhood magnitude impact at different ages. Methods: included children recruited to Boston-based Children's HealthWatch cohort from 2009 through 2014 (0 6 years...