A5073996239- SARS-CoV-2 and COVID-19 Research
- Circadian rhythm and melatonin
- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- Dietary Effects on Health
- Childhood Cancer Survivors' Quality of Life
- Animal Virus Infections Studies
- vaccines and immunoinformatics approaches
- T-cell and B-cell Immunology
- Long-Term Effects of COVID-19
- Immune Response and Inflammation
- IL-33, ST2, and ILC Pathways
- MicroRNA in disease regulation
- Gut microbiota and health
- Bone Metabolism and Diseases
- TGF-β signaling in diseases
- Immune Cell Function and Interaction
Casa Sollievo della Sofferenza
2021-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2023
Background: LC has been associated with hyporesponsiveness to several vaccines. Nonetheless, no data on complete serological and B- T-cell immune response are currently available. Aims: To assess, in comparison healthy controls of the same age gender, both humoral cellular immunoresponses patients after two or three doses mRNA Pfizer-BioNTech vaccine against SARS-CoV-2 investigate clinical features non-response. Material methods: 179 CTP class A 93.3% viral etiology 70.1% cases were...
Abstract Background T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy, characterized by restricted cellular subsets with asymmetrically enriched initiating cell (LIC) activity. Nonetheless, it still unclear which signaling programs promote LIC maintenance and progression. Methods Here, we evaluated the role of biological clock in regulation molecular mechanisms pathways impacting dynamics T-ALL through integrated experimental approach including gene...
The escalation of Coronavirus disease 2019 (COVID-19) has required the development safe and effective vaccines against severe acute respiratory syndrome coronavirus 2-associated (SARS-CoV-2), which is causative agent disease. Here, we determined levels antibodies, antigen-specific B cells, a recombinant GFP-tagged SARS-CoV-2 spike (S) protein total T NK cell subsets in subjects up to 20 days after injection BNT162b2 (Pfizer-BioNTech) vaccine using combined approach serological flow cytometry...
Remdesivir (RDV) has demonstrated clinical benefit in hospitalized COronaVIrus Disease (COVID)-19 patients. The objective of this brief report was to assess a possible correlation between RDV therapy and the variation lymphocyte subpopulations. We retrospectively studied 43 COVID-19 patients: 30 men 13 women (mean age 69.3 ± 15 years); 9/43 had received therapy. Six patients no need for oxygen (severity group 0); 22 were on treatment with fraction inspired (FiO2) ≤ 50% (group 1); 7...
Abstract Notch signaling is an evolutionary conserved pathway with a key role in tissue homeostasis, differentiation and proliferation. It was reported that Notch1 receptor negatively regulates mouse osteoclast development formation by inhibiting the expression of macrophage colony-stimulating factor mesenchymal cells. Nonetheless, involvement generation human osteoclasts still controversial. Here, we report constitutive activation induced block mononuclear CD14 + cells directly isolated...
Background: The worldwide escalation of Coronavirus Disease 2019 (COVID-19) has urgently required the development safe and effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is causative agent disease. BNT162b2 (Pfizer–BioNTech) RNA-based vaccine confers 95% protection COVID-19 by encoding a mutated isoform SARS-CoV-2 full-length spike (S) protein. Objective: Here, we report antigen-specific immune profile S protein after vaccination with single...