Elisa Visalli
A5056863629- Systemic Sclerosis and Related Diseases
- Rheumatoid Arthritis Research and Therapies
- Psoriasis: Treatment and Pathogenesis
- Spondyloarthritis Studies and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pregnancy and Medication Impact
- Dermatologic Treatments and Research
- Chronic Lymphocytic Leukemia Research
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Inflammatory Myopathies and Dermatomyositis
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Eosinophilic Esophagitis
- Dermatological and COVID-19 studies
- Mast cells and histamine
- Long-Term Effects of COVID-19
- Skin Diseases and Diabetes
- Monoclonal and Polyclonal Antibodies Research
- Hemophilia Treatment and Research
- Biosimilars and Bioanalytical Methods
- COVID-19 and Mental Health
- Heparin-Induced Thrombocytopenia and Thrombosis
- Dermatology and Skin Diseases
- SARS-CoV-2 and COVID-19 Research
- Urticaria and Related Conditions
Policlinico Universitario di Catania
2021-2024
Marconi University
2023
University of Padua
2022-2023
Azienda Ospedaliero-Universitaria Policlinico - Vittorio Emanuele
2016-2022
University of Catania
2017-2021
Consorzio Catania Ricerche
2017-2018
University of Messina
2013-2016
Azienda Ospedaliera Universitaria Policlinico "G. Martino"
2013-2015
Center for Rheumatology
2015
Objectives To evaluate in a multicentric Italian cohort of patients with psoriatic arthritis (PsA) on secukinumab followed for 24 months: (1) the long-term effectiveness and safety secukinumab, (2) drug retention rate minimal disease activity (MDA), (3) differences outcomes according to biological treatment line: biologic-naïve ( group A ) versus multifailure B patients. Methods Consecutive PsA receiving were evaluated prospectively. Disease characteristics, previous/ongoing treatments,...
Immune and vascular ageing are proposed risk factors for giant cell arteritis (GCA). Data on the impact of age at diagnosis GCA clinical presentation course disease scarce.Patients with followed referral centres within Italian Society Rheumatology Vasculitis Study Group were enrolled up to November 2021. Patients grouped according diagnosis: ≤64, 65-79 ≥80 years old.The study included 1004 patients, mean 72.1±8.4, female 70.82%. Median follow-up duration was 49 (IQR 23-91) months. in oldest...
Objective The aim of our study was to elucidate the pathophysiology systemic sclerosis-related osteoporosis and prevalence vertebral fragility fracture in postmenopausal women with sclerosis (SSc). Methodology Fifty-four scleroderma 54 controls matched for age, BMI, smoking habits were studied. BMD measured by dual energy-x-ray absorptiometry at spine femur, ultrasonography calcaneus markers bone turnover included serum osteocalcin urinary deoxypyridinoline. All subjects had a X-ray...
The ongoing COVID-19 pandemic caused by the novel β-coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a serious challenge for management of patients with different pre-existing comorbidities,1WHOCoronavirus disease 2019 (COVID-19): situation report, 51.https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200311-sitrep-51-covid-19.pdf?sfvrsn=1ba62e57_10Date: March 11, 2020Date accessed: 2020Google Scholar, 2Guan WJ Ni ZY Hu Y et al.Clinical...
Objective To describe demographic, clinical and laboratory features of systemic sclerosis sine scleroderma (ssSSc) in a large multicentre (SSc) cohort. Methods Data involving 1808 SSc patients from Italian Systemic PRogression INvestiGation registry were collected. The ssSSc was defined by the absence any cutaneous and/or puffy fingers. Clinical serological compared with limited (lcSSc) diffuse (dcSSc) subsets. Results Among SSc, only 61 (3.4%) classified as having (F/M=19/1). Time Raynaud’s...
Background: Tofacitinib (TOFA) was the first Janus kinase inhibitor (JAKi) to be approved for treatment of rheumatoid arthritis (RA). However, data on retention rate TOFA therapy are still far from definitive. Objective: The goal this study is add new real-world in a cohort RA patients followed long period time. Methods: A multicenter retrospective subjects treated with as monotherapy or combination conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) conducted 23 Italian...
Objective Bosentan (BOS) is approved for treating pulmonary arterial hypertension (PAH) and preventing digital ulcers (DU) in systemic sclerosis (SSc). Our study aimed to evaluate whether BOS prescribed DU could reduce the incidence of PAH a large SSc cohort from SPRING registry. Methods Patients with registry, meeting ACR/EULAR 2013 classification criteria data on onset, status, exposure, at least one-year follow-up between 2015 2020, no known baseline were included. was diagnosed right...
Intravenous iloprost is a first-line option for the treatment of scleroderma-related digital vasculopathy, and some studies have suggested its favourable role on disease progression. The aim our study to evaluate progression, specifically in terms cardiopulmonary function, group consecutive patients chronically treated with intravenous iloprost. Our retrospective enrolled 68 scleroderma (68 F, 54.4 ± 12.3 years) 7.1 2.9 years, schedule 5-6 daily infusions per month (6 h/day, 0.5-2.0...
Vitamin D status has been linked to immune system and autoimmune disorders; in fact, low levels of vitamin are common many disorders. The aims our study were assess the prevalence insufficiency possible correlation with clinical parameters systemic sclerosis (SSc). We recruited 40 patients (38 female two male) scleroderma healthy controls matched for age gender. Demographic recorded 25-hydroxivitamin D3 serum measured. Serum significantly lower than control group. was 50% 22.5% A...
Objective There is still a great deal to learn about the influence of sex in systemic sclerosis (SSc). In this respect, national registries provide large and homogeneous patient cohorts for analytical studies. We therefore investigated wide-ranging well-characterized SSc series with aim identifying differences disease expression, special focus on demographic, clinical, serological characteristics. Methods A multicenter cohort 2281 patients, including 247 men, was recruited Italian Systemic...
To evaluate, in a multicentric Italian cohort of axial spondyloarthritis (axSpA) patients on Secukinumab (SEC) followed for 24 months: (1) the long-term effectiveness and safety SEC; (2) drug retention rate low disease activity (LDA) measured as Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) < 4/Ankylosing Score (ASDAS) 2.1 very (VLDA) BASDAI 2/ASDAS 1.3; (3) any differences outcomes according to line biological treatment (naïve/non-naïve), gender (male/female), subtype axSpA...
Background: Systemic sclerosis is a complex autoimmune disease characterized by vasculopathy, fibrosis, and immune dysregulation. Ocular manifestations in these patients are increasingly recognized, suggesting potential correlations between systemic vascular abnormalities ocular microvascular changes. Advancements molecular immunology imaging technology using coherence tomography (OCT) have unveiled intricate pathways underlying possible pathogenesis. Understanding the interplay retinal...
Background/Objectives: The Janus kinase inhibitors (JAKi) tofacitinib (TOFA), baricitinib (BARI), upadacitinib (UPA), and filgotinib (FILGO) are effective drugs for the treatment of rheumatoid arthritis. However, US Food Drug Administration (FDA) raised concerns about safety TOFA after its approval. This prompted European Medicines Agency (EMA) to issue two warnings limiting use, then extended a third warning all JAKi in patients at high risk developing serious adverse effects (SAE). These...
In patients with SSc, peripheral vasculopathy can promote critical ischaemia and gangrene. The aim of this study was to investigate the prevalence, incidence risk factors for gangrene in EUSTAR cohort.We included from database fulfilling ACR 1980 or ACR/EULAR 2013 classification criteria at least one visit recording data on Centres were asked supplementary traditional cardiovascular factors. We analysed cross-sectional relationship between its potential by univariable multivariable logistic...
Background: Few studies have evaluated the effectiveness of adalimumab in real-life setting psoriatic arthritis (PsA). Objective: To evaluate 2-year retention rate PsA patients. Potential baseline parameters influencing persistence on treatment were also evaluated. Methods: patients from 16 Italian Rheumatology Units treated with as first- or second-line biological therapy retrospectively Adalimumab was at 12 and 24 months. Logistic regression used to association between predictor variables...
Background: The Covid-19 pandemic may have a deleterious impact on patients with autoimmune systemic diseases (ASD) due to their deep immune-system alterations. Objective: This study aims investigate the prevalence of symptomatic and its correlations both organ involvement ongoing treatments in large series Italian ASD during first wave pandemic. Methods: Our multicenter telephone 6-week survey included 3,029 unselected enrolled at 36 tertiary referral centers northern, central, southern...
The impact of COVID-19 pandemic represents a serious challenge for 'frail' patients' populations with inflammatory autoimmune systemic diseases such as sclerosis (SSc). We investigated the prevalence and severity COVID-19, well effects vaccination campaign in large series SSc patients followed entire period (first 38 months) pandemic.This prospective survey study included 1755 unselected (186 M, 1,569F; mean age 58.7 ± 13.4SD years, disease duration 8.8 7.3SD years) recruited part by...
Intravenous iloprost has been widely used for the treatment of systemic sclerosis peripheral vasculopathy. No agreement found on regimen and dosage intravenous in different scleroderma subset conditions. This study aimed to evaluate modalities administration within a large cohort patients from SPRING Registry identify any associated clinical-demographic, instrumental or therapeutic data.