A5038639967- Vasculitis and related conditions
- Otitis Media and Relapsing Polychondritis
- Systemic Lupus Erythematosus Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Eosinophilic Disorders and Syndromes
- Urticaria and Related Conditions
- Sarcoidosis and Beryllium Toxicity Research
- Vascular Anomalies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Peripheral Artery Disease Management
- Ocular Diseases and Behçet’s Syndrome
- Eosinophilic Esophagitis
- Retinal and Optic Conditions
- COVID-19 and healthcare impacts
- Peripheral Neuropathies and Disorders
- Pregnancy and Medication Impact
- Tracheal and airway disorders
- Autoimmune and Inflammatory Disorders Research
- Reproductive System and Pregnancy
- IgG4-Related and Inflammatory Diseases
- Autoimmune and Inflammatory Disorders
- Long-Term Effects of COVID-19
- Systemic Sclerosis and Related Diseases
- Immunodeficiency and Autoimmune Disorders
- Renal Diseases and Glomerulopathies
University of Pavia
2020-2025
Policlinico San Matteo Fondazione
2020-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2025
University of Siena
2024
Center for Rheumatology
2021
VEXAS syndrome is a recently described monogenic autoinflammatory disease capable of manifesting itself with wide array organs and tissues involvement. Orbital/ocular inflammatory manifestations are frequently in patients. The objective this study to further describe orbital/ocular conditions while investigating potential associations other manifestations. In the present study, twenty-seven out 59 (45.8%) patients showed an involvement during their clinical history. most frequent affections...
To investigate pregnancy outcomes in women with autoimmune rheumatic diseases (ARD) the Italian prospective cohort study P-RHEUM.it.
Objectives To assess the sensitivity to change of ultrasound halo features and their association with disease activity glucocorticoid (GC) treatment in patients newly diagnosed giant cell arteritis (GCA). Methods Prospective study ultrasound-confirmed GCA who underwent serial assessments temporal artery (TA) axillary (AX) at fixed time points. The number segments maximum intima–media thickness (IMT) was recorded. Time points which >80% were assessed considered for analysis. Halo...
Immune and vascular ageing are proposed risk factors for giant cell arteritis (GCA). Data on the impact of age at diagnosis GCA clinical presentation course disease scarce.Patients with followed referral centres within Italian Society Rheumatology Vasculitis Study Group were enrolled up to November 2021. Patients grouped according diagnosis: ≤64, 65-79 ≥80 years old.The study included 1004 patients, mean 72.1±8.4, female 70.82%. Median follow-up duration was 49 (IQR 23-91) months. in oldest...
To test the prognostic role of ultrasonography at diagnosis giant cell arteritis (GCA) and change ultrasound abnormalities during initial weeks follow-up for prediction relapse, vascular complications, or initiation disease-modifying antirheumatic drugs (DMARDs). Prospective, multicentre study patients with new onset GCA undergoing serial assessment fixed time points. The Outcome Measures in Rheumatology (OMERACT) score (OGUS) was used to quantify vessel wall abnormalities. Relapse defined...
Background: Tracheobronchial stenosis is a significant complication in granulomatosis with polyangiitis (GPA), systemic vasculitis that primarily affects the upper respiratory tract, kidneys, and lungs. The involvement of tracheobronchial tree GPA leads to airway narrowing, which can result severe symptoms increased morbidity, often requiring prompt diagnosis management prevent life-threatening obstruction. Method: We present case 28-year-old male mild exertional dyspnea, stridor,...
Abstract Objectives To prospectively evaluate the impact and rapidity of effect mepolizumab on ANCA-associated vasculitis patient-reported outcomes (AAV-PRO) questionnaire patient global assessment (PtGA) in an international, multicentre cohort patients with eosinophilic granulomatosis polyangiitis (EGPA). Methods Patients active EGPA initiating treatment were included. PtGA AAV-PRO score assessed at baseline after 7, 14, 30, 90 180 days. Predictors response investigated. Results Seventy...
<h3>Background:</h3> Prognostic parameters for the risk stratification of patients with giant cell arteritis (GCA) at diagnosis or during early phases disease are still lacking. The use ultrasound (US) as a monitoring tool assessment GCA follow-up is being increasingly recognized. provisional OMERACT score (OGUS) has been developed to monitor activity and shown good sensitivity change in prospective study [1]. It remains unclear whether findings play prognostic role predicting relapse, need...
Abstract Behçet’s disease (BD) is a heterogeneous multifactorial autoinflammatory characterized by plethora of clinical manifestations. Cutaneous lesions are considered hallmarks the disease. However, their evolution over time and thorough description scarcely reported in non-endemic regions. The aim this study was to detail BD skin manifestations Italy, as well dermatological prognostic impact specific cutaneous features long-standing Data were collected double fashion, both retrospectively...
Abstract Objectives To analyse the effectiveness, safety and steroid-sparing effect of AZA MTX as induction remission maintenance treatment in eosinophilic granulomatosis with polyangiitis. Methods We retrospectively collected data from 57 patients divided into four groups according to treatment: MTX/AZA first-line agents (MTX1/AZA1) non-severe disease or second-line therapy (MTX2/AZA2) severe previously treated CYC/rituximab. During first 5 years AZA/MTX we compared to: rate [defined R1:...
Background: Patient-reported outcomes (PROs) are currently poorly integrated in the clinical evaluation of disease activity patients with ANCA-associated vasculitis (AAV). Objectives: To assess distribution Patient Global Assessment (PtGA) AAV stable remission, and to identify correlates PtGA; discordance between PtGA score PhGA. Methods: Patients a diagnosis [eosinophilic granulomatosis polyangiitis, microscopic polyangiitis] stable, complete remission (defined by BVAS=0) Physician (PhGA)=0...
Background: Giant Cell Arteritis (GCA) is the most common form of primary systemic vasculitis, mainly affecting adults over 50 years old. Permanent visual loss (PVL) one feared complications, occurring in about 20% cases, typically prior to initiation high-dose glucocorticoid (GC) therapy. Color-duplex sonography (CDS) temporal arteries (TAs) and large vessels (LVs) recognized as a first-line diagnostic tool for patients with suspected GCA. A fast track approach (FTA), incorporating CDS has...
Background: Ultrasound of the temporal ± axillary arteries showing a non-compressible halo sign is recommended for diagnosing patients with giant cell arteritis (GCA); however, its value monitoring disease activity still poorly understood. Objectives: To assess sensitivity to change ultrasound features and their association glucocorticoid (GC) treatment in newly diagnosed GCA. Methods: Two centre prospective study new confirmed-GCA who underwent serial assessments (TA) (AX) at fixed...
<h3>Background</h3> Despite the clinical differences between EGPA and other AAVs, treatment guidelines are mostly based on evidence available for patients with MPA GPA, due to lack of enough randomized controlled trials [1]. <h3>Objectives</h3> The aim our study is analyse efficacy, safety steroid-sparing effect azathioprine (AZA) methotrexate (MTX) as induction maintenance therapy in EGPA. <h3>Methods</h3> We collected data from 57 retrospective divided 4 groups according received (MTX/AZA...
Abstract Background Human immunodeficiency virus (HIV) has a protean clinical picture, in rare instances manifesting as systemic autoimmune disorders such vasculitides. HIV-induced diseases often do not respond well to immunosuppressive therapy. Opportunistic infections may occur patients with either acquired syndrome (AIDS) or heavy treatment, and can further complicate the presentation. Case presentation A patient presenting immunoglobulin (IgA) vasculitis (IgAV) treatment-refractory...
Background: Following the introduction of effective immunosuppressive treatments, ANCA-associated vasculitides (AAV) have become chronic diseases with a remitting-relapsing course. Therefore, preventing damage accrual during follow-up is critical, as relapses, treatment-related side effects, and comorbidities may significantly affect long-term outcomes AAV patients. At present, no study specifically evaluated burden in patients eosinophilic granulomatosis polyangiitis (EGPA). Objectives: To...