A5031780378- Systemic Lupus Erythematosus Research
- Pregnancy and Medication Impact
- Rheumatoid Arthritis Research and Therapies
- Peripheral Neuropathies and Disorders
- Reproductive System and Pregnancy
- Systemic Sclerosis and Related Diseases
- Adenosine and Purinergic Signaling
- Eosinophilic Esophagitis
- Atherosclerosis and Cardiovascular Diseases
- Pregnancy and preeclampsia studies
- Cardiovascular Issues in Pregnancy
- Autoimmune Neurological Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammatory Myopathies and Dermatomyositis
- Viral Infections and Immunology Research
- Spondyloarthritis Studies and Treatments
- Endometriosis Research and Treatment
- Autoimmune and Inflammatory Disorders Research
- Eosinophilic Disorders and Syndromes
- Pharmacological Effects of Natural Compounds
- Hepatitis B Virus Studies
- Cytomegalovirus and herpesvirus research
- Protein Tyrosine Phosphatases
- Cell Adhesion Molecules Research
University of Ferrara
2015-2025
Arcispedale Sant'Anna
2010-2024
Ospedale Sant'Anna
2008-2021
St. Anna Hospital
2018
Università Cattolica del Sacro Cuore
2014
Società Italiana di Reumatologia
2014
University of Pisa
2014
Sapienza University of Rome
2014
University of Rijeka
1999
Obesity is a mild, long-lasting inflammatory disease and, as such, could increase the burden of rheumatoid arthritis (RA). The study aim was to determine whether obesity represents risk factor for poor remission rate in RA patients requiring anti-tumor necrosis α (anti-TNFα) therapy progressive and active despite treatment with methotrexate or other disease-modifying antirheumatic drugs.Patients were identified from 15 outpatient clinics university hospitals Italy taking part Gruppo Italiano...
To assess fetal and maternal outcomes in women with systemic sclerosis (SSc).Prospectively collected data on 99 SSc from 25 Italian centers were analyzed retrospectively. Women observed during 109 pregnancies (from 2000 to 2011), compared those the general obstetric population (total of 3,939 deliveries). The age at conception was a mean ± SD 31.8 5.3 years, median disease duration 60 months (range 2-193 months).SSc patients, population, had significantly increased frequency preterm...
Abstract Introduction The reduction of the inflammatory status represents one most important targets in rheumatoid arthritis (RA). A central role 2A and 3 adenosine receptors (ARs) mechanisms inflammation has been reported different pathologies. primary aim this study was to investigate ARs their involvement RA progression measured by Disease Activity Score 28 or 44 joints (DAS28 DAS). Methods were analyzed saturation binding assays, mRNA Western blotting analysis lymphocytes from early...
To investigate pregnancy outcomes in women with autoimmune rheumatic diseases (ARD) the Italian prospective cohort study P-RHEUM.it.
Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease mainly mediated by the deposit of immune complexes and defects in T lymphocytes antigen‐presenting cells along with a high production T‐helper 2 cytokines. A tolerance‐inducible function nonclassical class Ib human leukocyte antigen (HLA)‐G molecule innate adaptive cellular responses has been reported, suggesting role inflammatory diseases. 14 bp sequence insertion/deletion polymorphism (rs16375) 3′‐untranslated region...
Objective. To analyse risk factors and comorbidities potentially associated with CNS involvement in a large cohort of Italian patients affected by SLE. Methods. A number generic (not strictly SLE related) specific (disease to which all have been exposed the span 5 years before first neuropsychiatric (NP) event or last available observation were checked for their distribution was analysed 959 without NP involvement; events that occurred time frame 10 recorded categorized as related unrelated....
Abstract Objective To investigate A 1 , 2A 2B and 3 adenosine receptors in lymphocytes neutrophils from patients with early rheumatoid arthritis (ERA) as well RA treated methotrexate (MTX) or anti–tumor necrosis factor α (anti‐TNFα), compared those age‐matched healthy controls, to examine correlations between the status functionality of TNFα release NF‐κB activation. Methods Adenosine were analyzed by saturation binding assays Western blot analyses. We investigated potency typical agonists...
Rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic (PsA) are chronic inflammatory rheumatic diseases that affect joints, causing debilitating pain disability. Adenosine receptors (ARs) play a key role in the mechanism of inflammation, activation A2A A3AR subtypes is often associated with reduction status. The aim this study was to investigate involvement ARs patients suffering from early-RA (ERA), RA, AS PsA. Messenger RNA (mRNA) analysis saturation binding experiments...
Rheumatoid arthritis (RA) with concomitant hepatitis B virus (HBV) infection represents a therapeutic challenge due to the risk of HBV reactivation under immunosuppressive treatment. To date there are few data coming from anecdotal case reports that concern following treatment abatacept. This observational retrospective study was aimed assess safety profile abatacept in this particular clinical setting.Eleven Italian rheumatologic centers provided patients RA and positive serology treated...
Objective: Neonatal Lupus (NL) is a rare syndrome caused by placental transfer of maternal anti-SSA/Ro and anti-La/SSB autoantibodies to the fetus. The rarity this condition requires establishment multidisciplinary registries in order improve our knowledge. Method: Inclusion criteria retrospective study were confirmed positivity for and/or anti-SSB/La antibodies, presence II or III degree congenital heart block (CHB) utero neonatal period (up 30 days after birth). Result: Eighty-nine cases...
Objective Methotrexate (MTX) represents the antirheumatic drug mainly used in rheumatoid arthritis (RA). HLA-G antigens are inducible nonclassical major histocompatibility complex class Ib molecules important for maintaining anti-inflammatory conditions. The gene is characterized by a deletion/insertion polymorphism of 14 bp that controls specific mRNA stability and protein levels. It has been reported MTX therapy mediates an increase interleukin-10-producing cells. This cytokine...
To assess the relationship between clinical picture and neuroimaging in patients affected by SLE with without neuropsychiatric (NP) involvement.One hundred seven including 66 NP involvement (NPSLE) focal or diffuse presentation 41 underwent single photon emission computed tomography (SPECT) MRI.After stratification for involvement, 52 presentation, abnormalities detected MRI SPECT did not differ from NP; however, after combining two techniques, a normal result was more frequently observed (P...
A2A adenosine receptors (ARs) play a key role in the inhibition of inflammatory process. The purpose this study was to evaluate modulation A2AARs rheumatoid arthritis (RA) patients after different pharmacological treatments and investigate effect A2AAR stimulation rat model arthritis. We investigated density functionality RA progression by using longitudinal before methotrexate (MTX), anti-TNFα agents or rituximab treatments. were analyzed saturation binding assays lymphocytes from...
Adenosine is a purine nucleoside implicated in the regulation of innate and adaptive immune systems, acting through its interaction with four cell surface receptors: A1, A2A, A2B, A3. There intense interest understanding how adenosine functions health during disease, but surprisingly little known about actual role adenosine-mediated mechanisms systemic lupus erythematosus (SLE). With this background, aim present study was to test hypothesis that dysregulation A3 receptors (ARs) lymphocytes...
To investigate fetal/perinatal and maternal outcomes from a large multicentre cohort of women diagnosed with UCTD.This retrospective study describes the 224 pregnancies in 133 consecutive diagnosis UCTD, positive for ANA aged <45 years old at inclusion.Of analysed, 177 (79%) resulted live births, 45 (20.1%) miscarriages (defined as pregnancy loss before 12 weeks' gestation), 2 (0.9%) stillbirths (pregnancy after 20 gestation) 6 (2.7%) cases showed intrauterine growth restriction....