A5029278975- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Inflammatory Bowel Disease
- Inflammasome and immune disorders
- Systemic Lupus Erythematosus Research
- Psoriasis: Treatment and Pathogenesis
- Infectious Diseases and Tuberculosis
- Ocular Diseases and Behçet’s Syndrome
- Tuberculosis Research and Epidemiology
- Inflammatory Myopathies and Dermatomyositis
- Mechanisms of cancer metastasis
- Celiac Disease Research and Management
- Nuclear Receptors and Signaling
- PI3K/AKT/mTOR signaling in cancer
- Peptidase Inhibition and Analysis
- Platelet Disorders and Treatments
- Adolescent and Pediatric Healthcare
- Autoimmune and Inflammatory Disorders
- Hematological disorders and diagnostics
- Therapeutic Uses of Natural Elements
- Biomedical and Chemical Research
- Pregnancy and Medication Impact
- Systemic Sclerosis and Related Diseases
- Reproductive System and Pregnancy
University of Bari Aldo Moro
2019-2024
University of Messina
2020-2022
University of Campania "Luigi Vanvitelli"
2012
Poor data have been previously reported about the mutation rates in K-RAS, BRAF, and PIK3CA genes among patients with hepatocellular carcinoma (HCC). Here we further elucidated role of these pathogenesis primary hepatic malignancies. Archival tumour tissue from 65 HCC originating South Italy were screened for mutations candidate by direct sequencing. Overall, oncogenic detected 15 (23%) BRAF gene, 18 (28%) 1 (2%) K-RAS gene. Using statistical analysis, significantly correlated presence...
To investigate pregnancy outcomes in women with autoimmune rheumatic diseases (ARD) the Italian prospective cohort study P-RHEUM.it.
Aim of this paper is to present the design, construction, and modalities dissemination AutoInflammatory Disease Alliance (AIDA) International Registry for patients with systemic juvenile idiopathic arthritis (sJIA) adult-onset Still's disease (AOSD), which are pediatric adult forms same autoinflammatory disorder.This a clinical, physician-driven, population- electronic-based instrument implemented retrospective prospective collection real-world data. The data based on Research Electronic...
Background Psoriatic Arthritis (PsA) is a multifactorial disease, and predicting remission challenging. Machine learning (ML) promising tool for building multi-parametric models to predict clinical outcomes. We aimed at developing ML algorithm the probability of in PsA patients on treatment with Secukinumab (SEC). Methods undergoing SEC between September 2017 2020 were retrospectively analyzed. At baseline 12-month follow-up, we retrieved demographic characteristics, including Body Mass...
This article points out the design, methods, development and deployment of international registry promoted by AutoInflammatory Disease Alliance (AIDA) Network with aim to define assess paediatric adult patients immune-mediated scleritis. collects both retrospective prospective real-world data from non-infectious scleritis through Research Electronic Data Capture (REDCap) tool aims promote knowledge real-life evidence enrolled worldwide; also allows collection standardised data, ensuring...
The administration of mineral sulphur water is an alternative experimental approach for the treatment rheumatic diseases, such as osteoarthritis (OA), that cause degeneration bone and cartilage sufferance to patients. Chondroitin sulfate (CS) a symptomatic slow acting nutropeucital agent currently used in molecular therapy OA. Therefore, we have studied role efficacy selective soil paste from enriched spring (mud)-therapy alone or combination with CS study was performed on 40 C57 Black 6N...
Abbruzzese, Anna MD; Venerito, Vincenzo Lopalco, Giuseppe Fornaro, Marco Giannotta, Maria Iannone, Florenzo MD, PhD Author Information
Objective This paper points out the design, development and deployment of AutoInflammatory Disease Alliance (AIDA) International Registry dedicated to pediatric adult patients affected by Undifferentiated Systemic Diseases (USAIDs). Methods is an electronic registry employed for real-world data collection about demographics, clinical, laboratory, instrumental socioeconomic USAIDs patients. Data recruitment, based on Research Electronic Capture (REDCap) tool, designed obtain standardized...
The objective of this study was to assess the 10-year prevalence latent tuberculosis infection (LTBI) among Apulian patients with rheumatic diseases (RDs). Secondary endpoint record new cases active TB disease and LTBI treated biologic disease-modifying antirheumatic drugs (bDMARDs).We analysed results from included in BIOPURE registry 2009 2018, who underwent QuantiFERON-TB Gold In-tube (QFT-GIT) test as screening before bDMARDs treatment. Demographic clinical data were recorded at time...
<h3>Background:</h3> Mucocutaneous lesions represent the earliest and most frequent manifestations of Behçet's disease (BD), may become disabling leading to substantial effect on quality life. Recently efficacy small molecule inhibitor phosphodiesterase 4 apremilast in treating oral genital ulcers has been shown a phase 2 trial (1), whereas date no results from real world data are available. <h3>Objectives:</h3> The purpose present study was describe our experience with BD patients...
Fornaro, Marco MD; Carlino, Giorgio Abbruzzese, Anna Piccinni, R. PhD; Iannone, Florenzo MD, PhD Author Information
Dr. Frank P. Brooks, writing from a long and wide experience in physiology, has successfully produced concise summary of gastrointestinal function the mechanisms which control it. The monograph reviews recent vast contributions to physiology brief but lucid manner. Material, frequently poorly understood by practitioners (bile salt metabolism, fat digestion, micellar formation), is discussed simple, readable fashion does not suffer jerky style many summaries. organization content book are...
<h3>Background:</h3> Chronic inflammation may change lipid profile, thus current EULAR recommendations for cardiovascular (CV) management in polyarthritis suggest to assess cholesterol status when disease activity is stable or remission<sup>1</sup>. To date it still unclear whether mediated changes lipids profile could impact on CV risk algorithms and what score should be considered the reference one any status. <h3>Objectives:</h3> The aim of this study was evaluate influence modifications...
Background: Systemic lupus erythematosus (SLE) patients are at high risk for CV events, and EULAR recommends assessing the 10-year CV-risk using Systematic Coronary Risk Evaluation (SCORE) [1]. The QRISK3, another score to assess in UK population, considers different factors among which also SLE. Progetto Cuore (PCS) is validated estimate Italian people largely replicates SCORE project [2]. Objectives: This cross-sectional study aimed SCORE, QRISK3 and, first time, PCS a multicentric cohort...
Background: Latent tuberculous infection (LTBI) is very common in the world and screening for it essential before starting treatment with biotechnological drugs Objectives: The aims of our study were to assess prevalence Apulia LTBI among patients affected rheumatic disease record cases tuberculosis (TB) treated biologic agents. Methods: We analysed data included BIOPURE registry from 2008 2018, who underwent Quantiferon (QTF) test as routinely treatment. Demographic clinical recorded at...
Abstract Background MH and deep remission are the major therapeutic goals in treatment of ulcerative colitis (UC), but best strategy after reaching terms maintenance or de-escalation is still poorly defined. This retrospective study aimed to evaluate patients who maintained therapy vs. de-escalating treatment. Methods Data with UC reached mucosal healing were retrospectively investigated. Demographic data/gender, age), disease-related data (extension, duration, age at onset), together on...
Background: Rheumatoid arthritis (RA) patients present high cardiovascular (CV) morbidity and mortality EULAR recommends estimating their CV-risk [1]. The Systematic Coronary Risk Evaluation (SCORE) algorithm is suggested if National Guidelines are lack, but few data available about different strategies. Objectives: To estimate the 10-years using algorithms in RA compared to osteoarthritis (OA) patients, as control group. Methods: A total of 1467 (78.3% female; mean age 59.8±11.5 years;...