A5059066891- Systemic Lupus Erythematosus Research
- Pregnancy and Medication Impact
- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Renal Diseases and Glomerulopathies
- Maternal and Perinatal Health Interventions
- Cardiovascular Issues in Pregnancy
- Preterm Birth and Chorioamnionitis
- Pregnancy-related medical research
- Birth, Development, and Health
- Systemic Sclerosis and Related Diseases
- Liver Diseases and Immunity
- Eosinophilic Esophagitis
- Monoclonal and Polyclonal Antibodies Research
- Maternal and fetal healthcare
- Endometriosis Research and Treatment
- Vasculitis and related conditions
- Blood disorders and treatments
- Platelet Disorders and Treatments
- Eosinophilic Disorders and Syndromes
- Blood Coagulation and Thrombosis Mechanisms
- Diabetes and associated disorders
- Parvovirus B19 Infection Studies
- Dental Radiography and Imaging
- Assisted Reproductive Technology and Twin Pregnancy
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2013-2023
University of Brescia
2013-2023
Society for Maternal-Fetal Medicine
2019
Brescia University
2017
University Clinic of Traumatology
2009
University of Coimbra
2009
Universidade de Santo Amaro
2009
University of Turin
2005
University of Florence
2005
University of Modena and Reggio Emilia
2005
To assess the true prevalence of congenital complete heart block (CCHB) in infants anti-Ro/SSA-positive women known to have connective tissue disease (CTD) and, secondarily, evaluate other electrocardiographic abnormalities these newborns at birth.A prospective study was conducted 4 referral hospitals. One hundred anti-Ro/SSAA-positive mothers were followed up before they became pregnant and during index pregnancy. Counterimmunoelectrophoresis immunoblotting used test for antibodies...
To assess fetal and maternal outcomes in women with systemic sclerosis (SSc).Prospectively collected data on 99 SSc from 25 Italian centers were analyzed retrospectively. Women observed during 109 pregnancies (from 2000 to 2011), compared those the general obstetric population (total of 3,939 deliveries). The age at conception was a mean ± SD 31.8 5.3 years, median disease duration 60 months (range 2-193 months).SSc patients, population, had significantly increased frequency preterm...
Anti-Ro/SSA antibodies are associated with neonatal lupus but also considered a possible cause for unexplained pregnancy loss and adverse outcome. In large multicentres cohort study we have prospectively followed 100 anti-Ro/SSA positive women (53 systemic erythematosus (SLE)) during their 122 pregnancies 107 negative (58 SLE) (140 pregnancies). were tested by immunoblot counterimunoelectrophoresis. Mean gestational age at delivery (38 vs 37.9 weeks), prevalence of (9.9 18.6%), preterm birth...
The role of thrombophilia in the pathogenesis preeclampsia is controversial. aim this case-controlled study was to determine whether increases risk or interferes with its clinical course. A total 808 white patients who developed (cases) and women previous uneventful pregnancies (controls) matched for age parity were evaluated inherited acquired (factor V Leiden; factor II G20210A; methylenetetrahydrofolate reductase C677T; protein S, C, antithrombin III deficiency; anticardiolipin...
This study aimed to describe the long-term outcome and immunological status of children born mothers with antiphospholipid syndrome, determine factors responsible for childhood abnormalities, correlate child's profile their mothers.A prospective follow-up a European multicentre cohort was conducted. The consisted clinical examination, growth data, neurodevelopmental milestones antibodies (APL) screening. Children were examined at 3, 9, 24 months 5 years.134 analysed (female sex in 65 cases,...
<h3>Background</h3> Anti-β<sub>2</sub>-glycoprotein-I (anti-β<sub>2</sub>GPI) were demonstrated to be pathogenic in the antiphospholipid syndrome (APS). However, they can detected patients with no features of APS, especially those affected by systemic autoimmune diseases (SAD), and so healthy children. It has been suggested that anti-β<sub>2</sub>GPI against domain 1 (D1) associate thrombosis, while recognising 4/5 (D4/5) are present non-thrombotic conditions. <h3>Objective</h3> To evaluate...
Problem To determine which autoantibodies are associated with reproductive failure. Method of study Sera from 269 patients autoimmune disease and/or failure were analyzed for anti‐phospholipid (aPL), anti‐annexin‐V, anti‐lactoferrin, anti‐thyroglobulin, anti‐thyroid peroxidase, anti‐prothrombin, anti‐nuclear, and anti‐saccharomycetes cerevisiae antibodies (ASCA), by enzyme‐linked immunosorbent assay. Patients classified as: recurrent pregnancy loss (RPL), infertility, diseases. The results...
Objective: Neonatal Lupus (NL) is a rare syndrome caused by placental transfer of maternal anti-SSA/Ro and anti-La/SSB autoantibodies to the fetus. The rarity this condition requires establishment multidisciplinary registries in order improve our knowledge. Method: Inclusion criteria retrospective study were confirmed positivity for and/or anti-SSB/La antibodies, presence II or III degree congenital heart block (CHB) utero neonatal period (up 30 days after birth). Result: Eighty-nine cases...
To verify the neuropsychological development in offspring of patients with systemic lupus erythematosus (SLE), 47 children (23 male and 24 female) from affected women were studied. The tests applied related to children’s ages: Griffiths scale up four years, WPPSI metaphonological (MP, evaluating phonological consciousness) six years age, WISC-R test Rey (evaluating visual-space abilities) onwards; finally, specific for diagnosis learning disabilities (LD) between ages seven 13. Intelligence...
Abstract Objective To verify the occurrence of learning disabilities (LDs) in offspring women with primary antiphospholipid syndrome (APS) as a consequence fetal exposure to maternal antibodies (aPL), and evaluate impact chronic disease on children's development. Methods We studied 17 children mothers APS using standardized intelligence test (Wechsler Intelligence Scale for Children, Revised), specific LD battery tests (Sartori, MT groups' reading ability, math skills), questionnaire...
Objective: Antiphospholipid antibodies positivity (aPL) is considered as a risk factor for adverse pregnancy outcome (APO). The aim of this study was to determine the factors APO in patients with confirmed aPL positivity, isolated (aPL carriers) or associated definite primary antiphospholipid syndrome (PAPS). Methods: clinical and laboratory features 283 pregnancies occurring between 2000 2014 200 women were collected 3 Institutions. Results: rate live birth 87.9% observed 50 cases (17.7%)....
A human bone marrow-derived mesenchymal stromal cell (MSCs) and cord blood-derived CD34+ stem co-culture system was set up in order to evaluate the proliferative differentiative effects induced by MSCs on cells, reciprocal influences gene expression profiles. After 10 days of co-culture, non-adherent (SN-fraction) adherent (AD-fraction) cells were collected analysed separately. In presence MSCs, a significant increase number observed (fold = 14.68), mostly SN-fraction 13.20). This combined...
Objective: Antiphospholipid antibodies (aPL) are risk factors for thrombosis and adverse obstetric outcomes. The pregnancy outcome the treatment of so called “aPL carriers” patients (aPL positivity without clinical manifestations APS) still unclear. This study aims at retrospectively evaluate associated with complications in 62 aPL carriers pregnant women. Methods: Medical records women regularly attending 3 Rheumatology centres a Pregnancy Clinic from January 1994 to December 2015 were...
What evaluation and care is offered to women after unexplained recurrent pregnancy loss (RPL) or intra-uterine foetal death (IUFD) what are the reproductive outcomes?Women assessed for thrombophilia often treated with low-molecular weight heparin (LMWH) and/or low-dose aspirin (ASA).Randomized controlled trials (RCTs) on possible efficacy of heparins have been inconclusive due limited power detect a difference patient heterogeneity.Prospective multicentre cohort study performed in 12...
Objective To investigate systemic and fetal‐placental nitric oxide synthesis by biochemical molecular biology means in normal human pregnancy pre‐eclampsia. Design participants Three groups of women were studied healthy pregnant ( n = 8 ), with pre‐eclampsia age‐matched nonpregnant controls ). Pre‐eclamptic patients treated nifedipine (30–60 mg/day) for severe hypertension. Systemic was assessed at weeks 18–21, 29–32 38–39 pre‐eclamptic on admission to the hospital (29–32 weeks, 30 average),...