A5010373098- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Chromium effects and bioremediation
- Carcinogens and Genotoxicity Assessment
- Central Venous Catheters and Hemodialysis
- Muscle and Compartmental Disorders
- Platelet Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Complement system in diseases
- Nitric Oxide and Endothelin Effects
- Blood properties and coagulation
- Erythropoietin and Anemia Treatment
- Vasculitis and related conditions
- Polyamine Metabolism and Applications
- Adenosine and Purinergic Signaling
- Cystic Fibrosis Research Advances
- Ion Transport and Channel Regulation
- Ion channel regulation and function
- Intramuscular injections and effects
- Systemic Sclerosis and Related Diseases
- Biomedical Research and Pathophysiology
- Vascular Procedures and Complications
- Digital Economy and Work Transformation
- Blood Pressure and Hypertension Studies
- Sharing Economy and Platforms
Mario Negri Institute for Pharmacological Research
1996-2019
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2019
Ospedale Papa Giovanni XXIII
2019
University of Bergamo
1993
Scripps Research Institute
1993
Centro di Riferimento Oncologico
1993
Objective To investigate systemic and fetal‐placental nitric oxide synthesis by biochemical molecular biology means in normal human pregnancy pre‐eclampsia. Design participants Three groups of women were studied healthy pregnant ( n = 8 ), with pre‐eclampsia age‐matched nonpregnant controls ). Pre‐eclamptic patients treated nifedipine (30–60 mg/day) for severe hypertension. Systemic was assessed at weeks 18–21, 29–32 38–39 pre‐eclamptic on admission to the hospital (29–32 weeks, 30 average),...
Platelet-activating factor (PAF) has been suggested recently to play an important role in immune glomerulonephritis, favoring the formation of deposits glomeruli and contributing local inflammatory reaction. Here we sought investigate whether urinary PAF excretion was modified New Zealand Black x White mice a model genetically determined complex disease which mimics systemic lupus humans changes values correlated with extent proteinuria. To clarify possible "in vivo" relevance these findings...
The genotoxic potential of methylglyoxal (MG) was studied in Saccharomyces cerevisiae D7 and Salmonella typhimurium TA97 TA102 the presence absence metabolic activation system (S9 fraction) prepared from mouse liver induced with beta-naphthoflavone (beta-NF) sodium phenobarbital (PB). vivo effects on hepatic microsomal mixed function mono-oxygenase by MG were untreated, beta-NF or PB pre-treated mice. a direct-acting mutagen S. when tested up to maximum concentration 0.47 mg/plate. Mitotic...
Glomerular hyperfiltration in streptozotocin-induced diabetes mellitus rats may be mediated by atrial natriuretic peptide (ANP). We wanted to evaluate plasma levels of ANP and volume relation renal receptor density affinity 6 weeks after induction diabetes. Plasma immunoreactive were significantly higher hyperglycemic diabetic (75.2 +/- 8.3 pg/ml) than control animals (34.7 8.1 pg/ml; p less 0.01). Administration insulin keep normoglycemic normalized (30.5 5.2 pg/ml). In contrast, did not...
We investigated in an vitro system the effect of albumin on interaction between circulating platelets and artificial membranes used for hemodialysers. Using a recently described method we evaluated platelet adhesion to polymethylmethacrylate (PMMA) cuprophan (CU) hollow-fibers. Deposition washed radiolabelled these two was measured small dialysis filters with or without previous perfusion solution. Also amount that adhered after albumin. Platelet deposition PMMA significantly reduced by...
BACKGROUND: Dermatan sulphate (DS) is a selective thrombin inhibitor with antithrombotic properties and low bleeding potential. In preliminary studies it was reported to be effective for preventing clot formation in the haemodialysis circuit. METHODS: Ten patients on maintenance chronic renal failure underwent three consecutive investigation phases. phase 1 (individual dose titration), repeated dialyses were performed increasing doses of DS until successful dialysis obtained two sessions at...
The genotoxicity of chromium chloride was investigated in cells D7 strain Saccharomyces cerevisiae harvested either from logarithmic or stationary growth phase. A weak induction mifotic gene conversion and point reverse mutation obtained when the incubations were performed using phosphate buffer. No genetic effect observed Tris‐HCl experiments with 51Cr radiotracer demonstrated that Cr3+ ion enters yeast binds to DNA even if incubation mixture Tris HCl This behaviour could be due highest...
The influence of nitrilotriacetic acid (NTA), a substitute poliphosphates in laundry detergents, on mitotic gene conversion and point reverse mutation induced by sodium chromate chromium chloride was analyzed D7 strain Saccharomyces cerevisiae. NTA determined significant decrease convertogenic activity while the not affected. This can be due to direct interaction between or possible effect recombinational repair DNA‐breaks oxidizing activity. Both dissolved into liquid growth medium...