A5101475253- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Diet and metabolism studies
- Diabetes Treatment and Management
- Acute Kidney Injury Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Complement system in diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Nutritional Studies and Diet
- Blood Pressure and Hypertension Studies
- Liver Disease Diagnosis and Treatment
- Blood Coagulation and Thrombosis Mechanisms
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Sodium Intake and Health
- Renal Transplantation Outcomes and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Hormonal Regulation and Hypertension
- Neutropenia and Cancer Infections
- Renal and Vascular Pathologies
- Metabolism and Genetic Disorders
- Gout, Hyperuricemia, Uric Acid
- Parathyroid Disorders and Treatments
- Vasculitis and related conditions
- Sepsis Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
Mario Negri Institute for Pharmacological Research
2004-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2000-2024
University of Padua
1988-2020
Azienda Ospedaliero Universitaria Ospedali Riuniti
2010
Baxter (United States)
2006
Policlinico San Matteo Fondazione
2000-2006
To describe the prevalence and determinants of hyperfiltration (glomerular filtration rate [GFR] ≥120 mL/min/1.73 m(2)), GFR decline, nephropathy onset or progression in type 2 diabetic patients with normo- microalbuminuria.We longitudinally studied 600 hypertensive albuminuria <200 μg/min who were retrieved from two randomized trials testing renal effect trandolapril delapril. Target blood pressure (BP) was <120/80 mmHg, HbA(1c) <7%. GFR, albuminuria, glucose disposal (GDR) centrally...
Numerous formulas have been developed to estimate renal function from biochemical, demographic and anthropometric data. Here we compared derived 12 published prediction equations with glomerular filtration rate (GFR) measurement by plasma iohexol clearance as reference method in a group of 81 transplant recipients enrolled the Mycophenolate Mofetil Steroid Sparing (MY.S.S.) trial. Iohexol clearances were carried out all patients at months 6, 9 21 after surgery. All showed tendency toward GFR...
<i>Background/Aims:</i> Nephrotoxicity is the major limitation to cisplatin therapy for solid tumors. We aimed at evaluating whether early increases in serum/urine levels of neutrophil gelatinase-associated lipocalin (NGAL), a biomarker tubular damage and regeneration, predict cisplatin-induced acute kidney injury (AKI). <i>Methods:</i> compared changes serum creatinine NGAL (ELISA assay) 1 4 h 1, 2, 3, 7 15 days after infusion (70–80 mg/m<sup>2</sup>)...
In individuals with type 2 diabetes abdominal obesity, hyperfiltration is a risk factor for accelerated glomerular filtration rate (GFR) decline and nephropathy. this academic, single-center, parallel-group, prospective, randomized, open-label, blinded end point trial, consenting patients aged &gt;18 years, waist circumference &gt;94 (males) or &gt;80 (females) cm, serum creatinine &lt;1.2 mg/dL, normoalbuminuria were randomized (1:1) permuted blocks to 6 months of 25%...
Summary We have established a new, enzyme-linked immunosorbent assay (ELISA) for the detection of ADAMTS13 antigen using purified polyclonal rabbit anti-human IgG. Normal plasma levels span concentration 740 –1420ng/ml (median 1080ng/ml) resulting in an activity to ratio 0.48 1.68 U/µg. In cohort HUS patients, was normal range, whereas hereditary TTP patients were low undetectable, concordance with severe deficient activity. Plasma acquired found contain free as well autoantibody-bound...
Trials failed to demonstrate protective effects of investigational treatments on glomerular filtration rate (GFR) reduction in Autosomal Dominant Polycystic Kidney Disease (ADPKD). To assess whether above findings were explained by unreliable GFR estimates, this academic study we compared values centrally measured iohexol plasma clearance with corresponding estimated Chronic Epidemiology Collaboration (CKD-Epi) and abbreviated Modification Diet Renal (aMDRD) formulas ADPKD patients retrieved...
Mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil (MMF), is now routinely used as immunosuppressant in solid organ transplantation a fixed daily dose regimen (2 g/d) association with cyclosporine (CsA) and steroids. However, no correlation has been shown between MMF clinical outcome.Here we examined possibility optimizing dosing by drug pharmacokinetic monitoring 46 stable kidney transplant recipients. MPA plasma concentration profiles were measured reverse-phase...
Acetyl-l-carnitine (ALC), a mitochondrial carrier involved in lipid oxidation and glucose metabolism, decreased systolic blood pressure (SBP), ameliorated insulin sensitivity hypertensive nondiabetic subjects at high cardiovascular risk. To assess the effects of ALC on SBP glycemic control patients with hypertension, type 2 diabetes mellitus (T2D), dyslipidemia background statin therapy. After 4-week run-in period stratification according to previous therapy, were randomized 6-month,...
<b><i>Background/Aim:</i></b> In clinical research setting, accurate and precise measurement of glomerular filtration rate (GFR) is essential to overcome the limitations GFR estimation with equations, which are often unreliable. recent decades, a method for measuring by plasma clearance iohexol, non-ionic radiocontrast agent, was developed. To evaluate safety procedure, we aimed review all immediate adverse reactions that could be related iohexol administration in our...
Background. Renal artery stenosis is usually treated by angioplasty and stenting, but the effectiveness of graft perfusion difficult to establish on clinical grounds. Methods. We compared changes in Doppler ultrasound parameters such as resistive index peak systolic velocity with concomitant renal vascular resistances, blood velocity, wall shear stress measured before 1 month after percutaneous transluminal stenting 12 transplant patients stenosis. Results. After revascularization,...
OBJECTIVE To assess the effects of inhibited gastrointestinal cholesterol absorption in statin-treated dyslipidemic patients. RESEARCH DESIGN AND METHODS In a multicenter prospective randomized double-blind placebo-controlled trial, we primarily compared by ANCOVA effect 2-month ezetimibe (10 mg/day) or placebo therapy on LDL serum levels 108 type 2 diabetic patients with albuminuria &lt;200 μg/min and total concentrations &gt;135 mg/dl despite simvastatin treatment (40 mg/day)....
ABSTRACT. How to combine antirejection drugs and which is the optimal dose of steroids calcineurin inhibitors beyond first year after kidney transplantation maintain adequate immunosuppression without major side effects are far from clear. Kidney transplant patients on steroid, cyclosporine (CsA), azathioprine were randomized per-protocol biopsy (n = 30) or no-biopsy 29) 1 2 yr posttransplant. Steroid CsA discontinued reduced basis establish drug-related complications, acute rejection, graft...
Complement activation has been increasingly implicated in the pathogenesis of type 2 diabetes and its chronic complications. It is unknown whether complement factor H (CFH) genetic variants, which have previously associated with complement-mediated organ damage likely due to inefficient modulation, influence risk renal cardiovascular events response therapy angiotensin-converting enzyme inhibitors (ACEi) diabetic patients. Here, we analyzed c.2808G>T, (p.Glu936Asp) CFH polymorphism, tags H3...
Implementing shortened one-compartment iohexol plasma clearance models for GFR measurement is crucial since the gold standard inulin renal technique and reference two-compartment, 10-hour, 16-samplings method are clinically unfeasible. Inulin may precipitate anaphylactic shock. Four-hour 8-hour with Bröchner-Mortensen correction provide accurate measurements in patients estimated (eGFR) > or ≤40 mL/min/1.73m 2 , respectively. We compared performance of simplified 5-hour, 4-samplings,...
<b><i>Background/Aims:</i></b> Glomerular filtration rate (GFR) is the best index for evaluating renal function. We aimed to develop a simplified iohexol plasma clearance procedure GFR measurement in rats without urine collection, animal catheterization or anesthesia, with limited sampling and requiring blood instead of plasma, further reduce sample volume improve welfare. <b><i>Methods:</i></b> After injection (129.4 mg), samples were drawn...