A5078511492- Renal Diseases and Glomerulopathies
- COVID-19 Clinical Research Studies
- Sirtuins and Resveratrol in Medicine
- SARS-CoV-2 and COVID-19 Research
- Metabolism and Genetic Disorders
- Long-Term Effects of COVID-19
- Chronic Kidney Disease and Diabetes
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Complement system in diseases
- Birth, Development, and Health
- Heme Oxygenase-1 and Carbon Monoxide
- Autoimmune Bullous Skin Diseases
- Neural Networks and Applications
- Renal and related cancers
- T-cell and B-cell Immunology
- Genetic and Kidney Cyst Diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Inflammasome and immune disorders
- Neural dynamics and brain function
- Biochemical Acid Research Studies
- COVID-19 Impact on Reproduction
- Cardiac Ischemia and Reperfusion
- COVID-19 diagnosis using AI
Mario Negri Institute for Pharmacological Research
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2017-2025
University of Milan
2013-2019
RELX Group (United States)
2018-2019
University of Freiburg
2017
Universität Hamburg
2017
University Medical Center Hamburg-Eppendorf
2017
University of Genoa
1997-1998
Acute kidney injury (AKI) is a public health concern with an annual mortality rate that exceeds those of breast and prostate cancer, heart failure, diabetes combined. Oxidative stress mitochondrial damage are drivers AKI-associated pathology; however, the pathways mediate these events poorly defined. Here, using murine cisplatin-induced AKI model, we determined both oxidative associated reduced levels renal sirtuin 3 (SIRT3). Treatment AMPK agonist AICAR or antioxidant agent...
Mesenchymal stromal cells (MSCs) are renoprotective and drive regeneration following injury, although cellular targets of such an effect still ill-defined. Here, we show that human umbilical cord (UC)-MSCs transplanted into mice stimulate tubular to regain mitochondrial mass function, associated with enhanced microtubule-rich projections appear mediate trafficking create a reparative dialogue among adjacent cells. Treatment UC-MSCs in cisplatin-induced acute kidney injury (AKI) regulates...
Aims: Sirtuins, a family of NAD+-dependent deacetylases, are recognized as nondispensable regulators aging processes. Sirtuin 3 (SIRT3) is the main mitochondrial deacetylase that maintains bioenergetics, an essential prerequisite for healthy aging. In this study, using Sirt3 knockout (Sirt3-/-) mice, we sought to establish whether deficiency affected life span, endpoint has never been tested formally in mammals, and uncover mechanisms involved organ damage associated with Results:Sirt3-/-...
Microvascular thrombosis is associated with multiorgan failure and mortality in coronavirus disease 2019 (COVID-19). Although thrombotic complications may be ascribed to the ability of SARS-CoV-2 infect replicate endothelial cells, it has been poorly investigated whether, complexity viral infection human host, specific elements alone can induce damage. Detection circulating spike protein sera severe COVID-19 patients was evaluated by ELISA.
Activation of endothelin-A receptor (ET(A)R) by endothelin-1 (ET-1) drives epithelial-to-mesenchymal transition in ovarian tumor cells through β-arrestin signaling. Here, we investigated whether this pathogenetic pathway could affect podocyte phenotype proliferative glomerular disorders. In cultured mouse podocytes, ET-1 caused loss the differentiation marker synaptopodin and acquisition mesenchymal α-smooth muscle actin. promoted migration via ET(A)R activation increased β-arrestin-1...
Abstract More effective treatments for diabetic nephropathy remain a major unmet clinical need. Increased oxidative stress is one of the most important pathological mechanisms that lead to kidney damage and functional impairment induced by diabetes. Sirtuin 3 (SIRT3) main mitochondrial deacetylase critically regulates cellular reactive oxygen species (ROS) production detoxification. Honokiol natural biphenolic compound that, activating SIRT3, can carry out anti-oxidant, anti-inflammatory...
Renal activation of the complement system has been described in patients with diabetic nephropathy (DN), although its pathological relevance is still ill-defined. Here, we studied whether glomerular C3a, generated by uncontrolled activation, promotes podocyte damage, leading to proteinuria and renal injury mice type 2 diabetes. BTBR ob/ob exhibited loss, albuminuria, accompanied C3 deposits increased C3a receptor (C3aR) levels. Decreased nephrin α-actinin4 expression, coupled integrin-linked...
The spike protein of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) can interact with endothelial cells. However, no studies demonstrated the direct effect subunit 1 (S1) in inducing lung vascular damage and potential mechanisms contributing to injury. Here, we found that S1 injection mice transgenic for human angiotensin converting enzyme (ACE2) induced early loss thromboresistance at 3 days, as revealed by thrombomodulin von Willebrand factor (vWF) increase. In parallel,...
Recent studies in biometrics focus on one dimensional physiological signals commonly acquired medical applications, like electrocardiogram (ECG), electroencephalograms (EEG), phonocardiogram (PCG), and photoplethysmogram (PPG). In this context, an important application is continuous authentication scenarios since are frequently captured for long time periods order to monitor the health status of patients.
Shiga toxin (Stx)-producing Escherichia coli is the offending agent of postdiarrhea-associated hemolytic uremic syndrome (HUS), a disorder glomerular ischemic damage and widespread microvascular thrombosis. We previously documented that Stx induces complement activation, generating C3a responsible for thrombosis in experimental HUS. Here, we show presence C3 deposits on podocytes associated with podocyte loss HUS mice generated by coinjection Stx2 LPS. Because adhesion to basement membrane...
Italy was the first western country to experience a large Coronavirus Disease 2019 (COVID-19) outbreak and province of Bergamo experienced one deadliest COVID-19 outbreaks in world. Following peak epidemic mid-March, curve has slowly fallen thanks strict lockdown imposed by Italian government on 9th March 2020.
We examined the immune response in subjects previously infected with SARS-CoV2 and infection-naïve 9 months after primary 2-dose COVID-19 mRNA vaccination 3 booster dose a longitudinal cohort of healthcare workers. Nine vaccination, exhibited higher residual antibody levels, significant neutralizing activity against distinct variants compared to subjects. The humoral was associated levels receptor binding domain (RBD)-specific IgG+ IgA+ memory B cells. increased neither activity, nor T cell...
In autoimmune diseases, autoreactive B cells comprise only the 0.1-0.5% of total circulating cells. However, current first-line treatments rely on non-specific and general suppression immune system, exposing patients to severe side effects. For this reason, identification targeted therapies for diseases is an unmet clinical need.