A5103281972- Diabetes Treatment and Management
- Diabetes Management and Research
- Chronic Kidney Disease and Diabetes
- Blood Pressure and Hypertension Studies
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiovascular Function and Risk Factors
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Advanced Glycation End Products research
- COVID-19 Clinical Research Studies
- Hormonal Regulation and Hypertension
- Pancreatitis Pathology and Treatment
- Heart Failure Treatment and Management
- Sodium Intake and Health
- Diet, Metabolism, and Disease
- Metabolism and Genetic Disorders
- Neurological and metabolic disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease and Transplantation
- Gestational Diabetes Research and Management
University of Milano-Bicocca
2011-2024
Ospedale Papa Giovanni XXIII
2015-2024
Swansea University
2023
University of Padua
1996-2023
The University of Texas Southwestern Medical Center
2023
Novo Nordisk (Denmark)
2023
Universidad Autónoma de Madrid
2019
Azienda Usl 8 Arezzo
2017
University of Bergamo
2004-2016
Sanofi (United States)
2016
The multicenter double-blind, randomized Bergamo Nephrologic Diabetes Complications Trial (BENEDICT) was designed to assess whether angiotensin-converting-enzyme inhibitors and non-dihydropyridine calcium-channel blockers, alone or in combination, prevent microalbuminuria subjects with hypertension, type 2 diabetes mellitus, normal urinary albumin excretion.We studied 1204 subjects, who were randomly assigned receive at least three years of treatment trandolapril (at a dose mg per day) plus...
To describe the prevalence and determinants of hyperfiltration (glomerular filtration rate [GFR] ≥120 mL/min/1.73 m(2)), GFR decline, nephropathy onset or progression in type 2 diabetic patients with normo- microalbuminuria.We longitudinally studied 600 hypertensive albuminuria <200 μg/min who were retrieved from two randomized trials testing renal effect trandolapril delapril. Target blood pressure (BP) was <120/80 mmHg, HbA(1c) <7%. GFR, albuminuria, glucose disposal (GDR) centrally...
In type 2 diabetes, prevalence of nonalbuminuric renal impairment is increasing worldwide, though its clinical significance remains unclear. This large-cohort study aimed at evaluating the association this phenotype with cardiovascular risk factors and other complications.Type diabetic patients from Renal Insufficiency And Cardiovascular Events (RIACE) Italian Multicenter Study (n = 15,773), visiting consecutively 19 hospital-based Diabetes Clinics in years 2007-2008, were examined. Serum...
Insulin icodec is an investigational once-weekly basal insulin analogue for diabetes management.We conducted a 78-week randomized, open-label, treat-to-target phase 3a trial (including 52-week main and 26-week extension phase, plus 5-week follow-up period) involving adults with type 2 (glycated hemoglobin level, 7 to 11%) who had not previously received insulin. Participants were randomly assigned in 1:1 ratio receive or once-daily glargine U100. The primary end point was the change glycated...
Microalbuminuria is a risk factor for renal and cardiovascular disease. A role insulin resistance in the pathogenesis of microalbuminuria has been suggested but still unproven. In this case-control, cross-sectional study, we compared glucose disposal rate (GDR), measured by hyperinsulinemic-euglycemic clamp, 50 pairs matched type 2 diabetic patients with micro- or normoalbuminuria (main study) 29 macro- (substudy). main GDR was ∼25% lower than normoalbuminuric (5.20 ± 1.91 vs. 6.86 2.88 mg ·...
Poorer control of risk factors for cardiovascular disease (CVD) has been reported in diabetic women, as compared with men. It proposed that this finding is due to gender disparities treatment intensity. We investigated hypothesis a large contemporary cohort subjects type 2 diabetes.Observational, cross-sectional study.Consecutive patients diabetes from the Renal Insufficiency And Cardiovascular Events (RIACE) Italian multicentre study (n = 15 773), attending 19 hospital-based clinics...
Although a reduced estimated glomerular filtration rate (eGFR) was shown to be powerful independent predictor of cardiovascular disease (CVD), other studies suggested that it confers much lower risk than albuminuria alone, whereas the combination two abnormalities is associated with multiplicative risk. This study aimed at assessing association previous CVD events, either total or by vascular bed, eGFR and chronic kidney (CKD) phenotypes.This cross-sectional evaluated 15,773 patients type 2...
OBJECTIVE To evaluate the rate and determinants of concordance between advanced diabetic retinopathy (DR) chronic kidney disease (CKD), as assessed by both albuminuria estimated glomerular filtration (eGFR), in large cohort Renal Insufficiency And Cardiovascular Events (RIACE) Italian multicenter study. RESEARCH DESIGN AND METHODS Patients with type 2 diabetes (n = 15,773) visiting consecutively 19 hospital–based clinics years 2007 2008 were examined. DR was dilated fundoscopy. CKD defined...
Insulin icodec (icodec) is a novel once-weekly basal insulin analog. This trial investigated two approaches for switching to versus once-daily glargine 100 units/mL (IGlar U100) in people with type 2 diabetes receiving daily and one or more oral glucose-lowering medications.This multicenter, open-label, treat-to-target phase randomized (1:1:1) eligible insulin-treated (total dose 10-50 units) (HbA1c 7.0-10.0% [53.0-85.8 mmol/mol]) an initial 100% loading (in which only the first was doubled...
Abstract Background It is unclear whether insulin resistance (IR) contributes to excess mortality in patients with type 2 diabetes independent of diabetic kidney disease (DKD), which strongly associated IR and a major risk factor for cardiovascular (CVD), the main cause death these individuals. We tested this hypothesis from Renal Insufficiency And Cardiovascular Events Italian Multicentre Study. Methods This observational, prospective, cohort study enrolled 15,773 attending 19 Diabetes...
Abstract Aims The superiority of continuous subcutaneous insulin infusion (CSII) over multiple daily injections (MDI) with glargine is uncertain. In this randomized cross‐over study, we compared CSII and MDI in patients Type 1 diabetes well controlled CSII. primary end‐point was glucose variability. Methods Thirty‐nine [38.1 ± 9.3 years old (mean sd ), duration 16.6 8.2 years, glycated haemoglobin (HbA 1c ) 7.6 0.8%], already on for at least 6 months, were randomly assigned to lispro or...
To determine the effects of physiological and pharmacological insulin concentrations on leucine-carbon kinetics in vivo, eight postabsorptive normal volunteers were infused with L-[4,5-3H]leucine alpha-[1-14C]ketoisocaproate (KIC). Insulin sequentially raised from 8 +/- 1 to 43 6 101 14 1,487 190 microU/ml, while maintaining euglycemia adequate glucose infusions. At end each 140-min insulin-infusion period, steady-state estimates leucine KIC rates appearance (Ra), (approximately...
To assess whether angiotensin-converting enzyme inhibitors and third-generation dihydropyridine calcium channel blockers ameliorate diabetic complications, we compared glomerular filtration rate (GFR; primary outcome), cardiovascular events, retinopathy, neuropathy in 380 hypertensive type 2 diabetics with albuminuria <200 mg/min included a multicenter, double-blind, placebo-controlled trial (DEMAND [Delapril Manidipine for Nephroprotection Diabetes]) randomized to 3-year treatment...