A5020966200- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Diet, Metabolism, and Disease
- Alcohol Consumption and Health Effects
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood Pressure and Hypertension Studies
- Diabetes Management and Education
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Birth, Development, and Health
- Folate and B Vitamins Research
- Liver Disease and Transplantation
- Diabetes Management and Research
- Metabolism and Genetic Disorders
- Pancreatitis Pathology and Treatment
- Physical Activity and Health
- Sodium Intake and Health
- Nutrition and Health in Aging
- Neuroinflammation and Neurodegeneration Mechanisms
- Renal function and acid-base balance
- Global Public Health Policies and Epidemiology
- Horticultural and Viticultural Research
Universitat de les Illes Balears
2018-2025
Health Research Institute of the Balearic Islands
2020-2025
Research Institute of Health Sciences
2021-2023
Instituto de Salud Carlos III
2018-2020
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2020
Mario Negri Institute for Pharmacological Research
2011-2019
Universidad de Navarra
2018
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2016
Aarhus University Hospital
2015
University of Roehampton
2008
Abstract The prevalence of obesity has tripled over the past five decades. Obesity, especially visceral obesity, is closely related to hypertension, increasing risk primary (essential) hypertension by 65%–75%. Hypertension a major factor for cardiovascular disease, leading cause death worldwide, and its rapidly following pandemic rise in obesity. Although causal relationship between high blood pressure (BP) well established, detailed mechanisms such association are still under research. For...
In individuals with type 2 diabetes abdominal obesity, hyperfiltration is a risk factor for accelerated glomerular filtration rate (GFR) decline and nephropathy. this academic, single-center, parallel-group, prospective, randomized, open-label, blinded end point trial, consenting patients aged >18 years, waist circumference >94 (males) or >80 (females) cm, serum creatinine <1.2 mg/dL, normoalbuminuria were randomized (1:1) permuted blocks to 6 months of 25%...
Background: Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive fat accumulation, especially triglycerides, in hepatocytes. If the pathology not properly treated, it can progress to nonalcoholic steatohepatitis (NASH) and continue fibrosis, cirrhosis or hepatocarcinoma. Objective: The aim of current research was identify plasma biomarkers damage, oxidative stress inflammation that facilitate early diagnosis control its progression. Methods: Antioxidant inflammatory were...
Despite the extensive scientific evidence accumulating on epidemiological risk factors for non-alcoholic fatty liver disease (NAFLD), exploring sex- and age-related differences remains insufficient. The present cross-sectional study aims to investigate possible sex in prevalence of FLI-defined NAFLD as well its association with common across different age groups, a large sample Spanish working adults.This included data from 33,216 adult workers (18-65 years) randomly selected during...
To assess the association between physical activity (PA), sedentary time (ST), and sleep with body composition, to explore effects of reallocating ST PA or on composition in individuals prediabetes overweight/obesity. Baseline data from PREDIPHONE trial, including 159 participants (mean age 59.6 years) (Fasting Plasma Glucose 100-125 mg/dl) overweight/obesity (Body Mass Index 27-40 kg/m²), were analyzed. Body was assessed via bioelectrical impedance, while PA, ST, measured accelerometry....
AimsIn type 2 diabetic patients with obesity, hyperfiltration is a risk factor for accelerated glomerular filtration rate (GFR) decline and ameliorated by calorie restriction (CR). We assessed whether CR-induced amelioration of could translate into slower long-term GFR in this population.MethodsIn academic, single-center, parallel-group, prospective, randomized, open-label, blinded endpoint trial, consenting >40-year-old diabetes, BMI ≥27 kg/m2, creatinine <1.2 mg/dL albuminuria ≤300 mg/24 h...
To assess the efficacy of three lifestyle interventions on reduction liver fat content and metabolic syndrome (MetS), whether such reductions would influence renal outcomes, we conducted a randomized controlled trial 128 participants with MetS non-alcoholic fatty disease (NAFLD), as well available data estimated glomerular filtration rate (eGFR) urinary albumin-to-creatine ratio (UACR). Patients were in 1:1:1 to either Conventional Diet, Mediterranean diet (MD)-high meal frequency,...
Lower socio-economic status (SES) is significantly associated with metabolic syndrome (MS) prevalence, possibly affecting women more than men, although evidence in Spain still limited. The present cross-sectional study analyzed the association between MS and SES by age gender among 42,146 working adults living Balearic Islands (Spain). Prevalence was higher men (9.4% ATP-III; 12.3% IDF) (3.8% 5.7% lower social class (7.9% 10.7% (4.1% 5.9% IDF). gradient prevalence larger (PR 95% CI: 3.38,...
Background Fatty Liver Index (FLI) is strongly associated with changes in glycemic status and incident Type 2 Diabetes (T2D). The probability of reverting to normoglycemia from a state prediabetes could be determined by FLI, however such relationship remains poorly understood. Aim To determine the clinical interest using FLI estimate reversion at 5 years patients impaired fasting plasma glucose baseline, identify those factors that contribute prediabetes. Methods This 5-year cohort study...
Abstract Background Metabolic dysfunction‐associated fatty liver disease (MAFLD, 2020 diagnostic criteria) and glomerular hyperfiltration share common risk factors, including obesity, insulin resistance, impaired glucose tolerance, diabetes, dyslipidemia, hypertension. Aims To assess the prevalence of MAFLD its association with age‐related worsening kidney function in subjects normoglycemia, prediabetes type 2 diabetes mellitus (T2DM). Methods We analysed data recorded during occupational...
Reactive oxygen species (ROS) such as hydrogen peroxide (H₂O₂) can exert opposed effects depending on the dosage: low levels be involved in signalling and adaptive processes, while higher deleterious cells tissues. Our aim was to emulate a chronic ex vivo oxidative stress situation through 2 h exposure of immune sustained H₂O₂ produced by glucose oxidase (GOX), at high or production rate, order determine dissimilar responses peripheral blood mononuclear (PBMCs) neutrophils ROS cytokine...
To investigate the prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) in prediabetes, visceral obesity, and preserved kidney function, explore whether MAFLD is associated with hyperfiltration.We analyzed data from 6697 Spanish civil servants, aged 18-65 years, fasting plasma glucose ≥ 100 ≤ 125 mg/dL (prediabetes, ADA), waist circumference 94 cm men 80 women (visceral IDF) de-indexed estimated glomerular filtration rate (eGFR) 60 ml/min, collected during occupational...
Abstract Aim To evaluate the effectiveness of a nurse‐led personalized telephone lifestyle intervention versus automated SMSs in reduction fasting plasma glucose adults with prediabetes. Design The PREDIPHONE is randomized controlled, parallel, two arms, superiority trial 15 months follow‐up. Participants will be to either group (teleconsultations) or active control (SMSs). Methods A total 428 participants 1:1 ratio one arms and followed up during 9 months. teleconsultations receive advice,...
Background: Non-alcoholic fatty liver disease (NAFLD) is a risk factor for the development of chronic kidney (CKD), which early marked by glomerular hyperfiltration. However, association NAFLD with hyperfiltration has not been tested so far in adults metabolic syndrome (MetS). Aims: To assess relationship between and MetS. Methods: The study included 154 participants aged 40–60 years MetS diagnosed ultrasound. was confirmed MRI 109 subjects. Participants underwent anthropometric...
Non-alcoholic fatty liver disease (NAFLD) is a global health problem associated with morbimortality, obesity, and type 2 diabetes mellitus. This study aimed to analyze the prevalence of NAFLD (defined as index [FLI] ≥ 60) its association other cardiovascular risk (CVR) factors in patients prediabetes overweight/obesity. The present cross-sectional analysis uses baseline data from an ongoing randomized clinical trial. Sociodemographic anthropometric characteristics, CVR (assessed by...