A5018320268- Parathyroid Disorders and Treatments
- Vitamin D Research Studies
- Bone health and treatments
- Dialysis and Renal Disease Management
- Pharmacological Effects and Toxicity Studies
- Magnesium in Health and Disease
- Bone health and osteoporosis research
- Bone and Joint Diseases
- Genetic Syndromes and Imprinting
- Neurological and metabolic disorders
- Trace Elements in Health
- Genetic and Kidney Cyst Diseases
- Central Venous Catheters and Hemodialysis
- Thyroid and Parathyroid Surgery
- Hemodynamic Monitoring and Therapy
- Metabolism and Genetic Disorders
- Biomedical Research and Pathophysiology
- Renal function and acid-base balance
- Chronic Kidney Disease and Diabetes
- Alkaline Phosphatase Research Studies
- Folate and B Vitamins Research
- Medical Imaging and Pathology Studies
- Renal and Vascular Pathologies
- Pediatric Urology and Nephrology Studies
- Erythropoietin and Anemia Treatment
Sapienza University of Rome
2016-2025
Policlinico Umberto I
2015-2025
RELX Group (United States)
2019
International Society of Nephrology
2019
Istituto Superiore di Sanità
1985-2015
Suez Canal University
2015
University of Messina
2009-2015
Ghent University Hospital
2015
Sociedade Brasileira de Anestesiologia
2014
Canadian Society of Nephrology
2013
The concept of chronic kidney disease-mineral bone disorder (CKD-MBD) does not appear to fulfil the requirements for a syndrome at first glance, but its definition has brought some clear-cut benefits clinicians and patients, including wider more complex diagnostic therapeutic approaches management this challenging set issues. Admittedly, all components CKD-MBD are present in patients times, these highly interrelated, involving mineral laboratory abnormalities, clinical histological disease...
ABSTRACT Mineral and bone disorders (MBD) are common in patients with chronic kidney disease (CKD), contributing to significant morbidity mortality. For several decades, the first-line approach controlling hyperparathyroidism CKD was by exogenous calcium loading. Since turn of millennium, however, a growing awareness vascular calcification risk has led paradigm shift management move away from calcium-based phosphate binders. As consequence, contemporary may be at negative balance, which,...
BackgroundSecondary hyperparathyroidism increases the risk of fractures and cardiovascular (CV) disease in hemodialysis (HD) patients. The relationship between parathyroid hormone (PTH) outcomes has been inconsistent, possibly due to variable bone responsiveness PTH. KDIGO guideline suggests monitoring total alkaline phosphatase (ALP), but role ALP versus PTH management mineral disorder is not clear.MethodsThe analysis included 28,888 HD patients 9 countries DOPPS phase 3-7 (2005-2021)....
ABSTRACT Uremic secondary hyperparathyroidism (SHP) refers to the biochemical abnormalities that characterize CKD-MBD. However, historically parathyroid hormone (PTH) is identified as key culprit and essential biomarker of hyperparathyroidism. SHP represents adaptive response several mineral initiate maintain increased PTH secretion through classical derangements more recently elucidated hormonal dysregulations. Among classic factors involved in pathogenesis SHP, phosphate, calcium,...
Renal osteodystrophy has been studied less extensively in predialysis than dialysis patients. Different types or histological patterns their natural evolution from moderate to advanced severity of renal insufficiency are only partially known, with special regard adynamic bone disease and its relationship osteomalacia.We conducted a cross-sectional retrospective study on 76 unselected patients chronic failure undergoing conservative treatment, wide range insufficiency. All the were subjected...
Renal osteodystrophy includes a number of low and high turnover bone histologic patterns which require biopsy for their full identification. The role intact PTH several classical more recent markers in the non-invasive diagnosis renal disease patients with CRF HD requires further definition since available published data are limited.In addition to PTH, alkaline phosphatase (AP) osteocalcin (BGP), isoenzyme (BALP), tartrate resistant acid (TRAP), C-terminal cross-linked peptide collagen type...
Transplantation should favorably affect coronary calcification (CAC) progression in dialysis; however, changes CAC score the individual patient are not reliably evaluated.The authors used special tables of reproducibility limits for each level to study, by multislice computed tomography and biochemistries, 2-year 41 transplant patients (age 48 +/- 13 yr, 25 men, dialysis vintage 4.8 4.3 underwent 6.2 5.5 yr prior). Thirty balanced served as controls.In study group, Agatston was stable,...
Transmembrane α -Klotho (TM-Klotho), expressed in renal tubules, is a cofactor for FGF23-receptor. Circulating soluble- (s-Klotho) results from TM-Klotho shedding and acts on Phosphate (P) Calcium (Ca) tubular transport. Decreased TM-Klotho, described experimental chronic kidney disease (CKD), prevents actions of FGF23 lessens circulating s-Klotho. Thus, levels s-Klotho could represent marker CKD-MBD. To evaluate the clinical significance CKD we assayed serum 68 patients (age<mml:math...
Renal osteodystrophy (ROD) is a heterogeneous group of metabolic bone diseases complicating progressive chronic kidney disease (CKD). Bone biomarkers and imaging techniques may help to assess health predict fractures in CKD but do have important inherent limitations. By informing on turnover mineralization, biopsy guide prevention treatment ROD its consequences. According recent survey conducted among European nephrologists, biopsies are performed rather exceptionally, both for clinical...
It is increasingly acknowledged that mineral and bone disorders (MBDs) contribute to the excessively high cardiovascular (CV) disease morbidity mortality observed in patients with chronic kidney (CKD). There ongoing debate as whether screening for CV calcification, one of hallmarks CKD-MBD, should be implemented clinical practice CKD. Issues considered this controversy relate prevalence, severity, relevance, last but not least, modifiability reversibility vascular valvular calcifications...