A5101583718- Dialysis and Renal Disease Management
- Parathyroid Disorders and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Pharmacological Effects and Toxicity Studies
- Neurological and metabolic disorders
- Lung Cancer Diagnosis and Treatment
- Alzheimer's disease research and treatments
- Bone and Joint Diseases
- Renal Diseases and Glomerulopathies
- Colorectal Cancer Treatments and Studies
- Chronic Kidney Disease and Diabetes
- Organ Transplantation Techniques and Outcomes
- Magnesium in Health and Disease
- Liver Disease and Transplantation
- Nutrition and Health in Aging
- Retinal Development and Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Liver Disease Diagnosis and Treatment
- Muscle and Compartmental Disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Autoimmune Bullous Skin Diseases
- Renal Transplantation Outcomes and Treatments
- Asthma and respiratory diseases
Niigata University
2016-2025
Niigata University Medical and Dental Hospital
2016-2025
Japanese Society for Dialysis Therapy
2024
Osaka Minami Medical Center
2006-2022
City Hospital
2021
Saitama Municipal Hospital
2021
Osaka Police Hospital
2011-2019
National Cerebral and Cardiovascular Center
1998-2019
Ichinomiya Kenshin College
2019
Nishijin Hospital
2019
Most patients with idiopathic pulmonary fibrosis (IPF) show slowly progressive deterioration. However, accelerated deterioration also occurs in patient IPF who have previously shown The purpose of this study was to evaluate the CT findings IPF.We evaluated 17 fulfilled all following criteria for IPF: exacerbation dyspnea within 1 month, new diffuse opacities on chest radiography, a decrease arterial oxygen tension (PaO2) more than 10 mm Hg under similar conditions, and absence apparent...
In β2-microglobulin-related (Aβ2M) amyloidosis, partial unfolding of β2-microglobulin (β2-m) is believed to be prerequisite its assembly into Aβ2M amyloid fibrils in vivo. Although low pH or 2,2,2-trifluoroethanol at a concentration has been reported induce β2-m and subsequent fibril formation vitro, factors that them under near physiological conditions have not determined. Using fluorescence spectroscopy with thioflavin T, circular dichroism spectroscopy, electron microscopy, we here show...
LBA4513 Backgrounds: We conducted a 3-arm phase III study to investigate superiority of CP and non-inferiority S-1 5-FU for advanced gastric cancer in the primary endpoint overall survival (OS) secondary endpoints response rate (RR), time treatment failure (TTF), non-hospitalized (NHS) toxicities. Methods: Treatments with (800mg/m 2 /d, ci, d1–5, q4w), (irinotecan, 70mg/m , div, d1&15 cisplatin, 80mg/m d1, q4w) (40mg/m b.i.d., d1- 28, q6w) were continued until disease progression or...
Objective— Angiotensin II is a major determinant of atherosclerosis. Although macrophages are the most abundant cells in atherosclerotic plaques and express angiotensin type 1 receptor (AT1), pathophysiologic role macrophage AT1 atherogenesis remains uncertain. We examined contribution to accelerated atherosclerosis an II-responsive setting induced by uninephrectomy (UNx). Methods Results— −/− or +/+ marrow from apolipoprotein E deficient (apoE ) mice was transplanted into recipient apoE...
BackgroundSecondary hyperparathyroidism increases the risk of fractures and cardiovascular (CV) disease in hemodialysis (HD) patients. The relationship between parathyroid hormone (PTH) outcomes has been inconsistent, possibly due to variable bone responsiveness PTH. KDIGO guideline suggests monitoring total alkaline phosphatase (ALP), but role ALP versus PTH management mineral disorder is not clear.MethodsThe analysis included 28,888 HD patients 9 countries DOPPS phase 3-7 (2005-2021)....
ABSTRACT. β<sub>2</sub>-Microglobulin–related (Aβ2M) amyloidosis is a frequent and serious complication in patients on long-term dialysis, β<sub>2</sub>-microglobulin major structural component of Aβ2M amyloid fibrils. Several biologic molecules inhibiting the depolymerization fibrils at neutral pH were found recently. The effect trifluoroethanol glycosaminoglycans (GAG) extension was investigated with use fluorescence spectroscopy thioflavin T, circular dichroism spectroscopy, electron...
Abstract Accumulation of protein-bound uraemic toxins (PBUTs) is one the reasons for development uraemia-related complications including cardiovascular disease; however, conventional haemodialysis limited in its ability to remove PBUTs. We aimed examine whether oral charcoal adsorbent AST-120 has an additive effect on PBUT removal patients. During 4-week study, anuric patients undergoing received (6 g/day) last 2 weeks (n = 10) or first 10). Serum levels total and free PBUTs such as indoxyl...
Cardiovascular disease (CVD) frequently occurs in patients with chronic kidney (CKD), particularly those undergoing dialysis. The mechanisms behind this may be related to traditional risk factors and CKD-specific that accelerate atherosclerosis vascular calcification CKD patients. accumulation of uremic toxins is a significant factor CKD-related systemic disorders. Basic research suggests indoxyl sulfate (IS), small protein-bound toxin, associated macrophage dysfunctions, including increased...
Background. Accelerated atherosclerosis and increased cardiovascular events are not only more common in chronic kidney disease (CKD) but resistant to therapeutic interventions effective the general population. The oral charcoal adsorbent, AST-120, currently used delay start of dialysis, reduces circulating tissue uremic toxins, which may contribute vasculopathy, including atherosclerosis. We, therefore, investigated whether AST-120 affects CKD-induced Methods. Apolipoprotein E-deficient...
Infectious disease is the second leading cause of death among dialysis patients, and it generally assumed that mortality rate infectious considerably higher in patients than general population. There are no comprehensive studies on this issue contribution each category to excess Japan. We used data reported Japanese Society for Dialysis Therapy national Vital Statistics 2008 2009. calculated standardized ratios compared rates disease. During 2-year study period, 274,683 10,435 deaths from...
Background Few risk scores are available for predicting mortality in chronic kidney disease (CKD) patients undergoing predialysis nephrology care. Here, we developed a score using practice data to predict 1-year following the initiation of haemodialysis (HD) CKD patients. Methods This was multicenter cohort study involving who started HD between April 2006 and March 2011 at 21 institutions with care services. Patients had not received an estimated glomerular filtration rate (eGFR)...
In chronic kidney disease (CKD) patients, accumulation of uremic toxins is associated with cardiovascular risk and mortality. One the hallmarks disease-related intravascular macrophage inflammation, but mechanism reaction these not completely understood. Macrophages differentiated from THP-1 cells were exposed to indoxyl sulfate (IS), a representative toxin, changes in inflammatory cytokine production intracellular signaling molecules including interleukin (IL)-1, aryl hydrocarbon receptor...
Abstract Background Coronavirus disease 2019 (COVID-19) is known to deteriorate nutrition in the general population. However, influence of COVID-19 on nutritional status patients undergoing maintenance hemodialysis remains unclear. Methods A retrospective study was conducted a hospital that had an outbreak severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. diagnosed using antigen test, and subjects were divided into control groups. Data body mass index, biochemistry...
Amyloid fibrils, crystal-like fibrillar aggregates of denatured proteins, are formed as a result the breakdown supersaturation, causing series amyloidosis including Alzheimer's and Parkinson's diseases. Although varying in vitro factors known, vivo breaking supersaturation unclear. We found that flowing by peristaltic pump effectively triggers amyloid formation hen egg white lysozyme, model amyloidogenic protein, and, moreover, amyloidosis-associated proteins (i.e., α-synuclein, β 1–40,...