A5013465818- Asthma and respiratory diseases
- Occupational exposure and asthma
- Allergic Rhinitis and Sensitization
- Renal Diseases and Glomerulopathies
- MRI in cancer diagnosis
- Genetic and Kidney Cyst Diseases
- Chronic Kidney Disease and Diabetes
- Food Allergy and Anaphylaxis Research
- Pediatric Urology and Nephrology Studies
- Meat and Animal Product Quality
- Advanced MRI Techniques and Applications
- Heart Failure Treatment and Management
- Renal and related cancers
- Atrial Fibrillation Management and Outcomes
- Protein Hydrolysis and Bioactive Peptides
- Hormonal Regulation and Hypertension
- Inhalation and Respiratory Drug Delivery
- Cardiovascular and Diving-Related Complications
- Sulfur Compounds in Biology
- Ion Transport and Channel Regulation
- Lymphatic System and Diseases
- Occupational and environmental lung diseases
- Personality Traits and Psychology
- Neonatal Health and Biochemistry
- IgG4-Related and Inflammatory Diseases
Niigata University Medical and Dental Hospital
2015-2025
Niigata University
2012-2024
Vanderbilt University Medical Center
2019-2022
Kinan Hospital
2018
Tachikawa Medical Center
2018
Nippon Sport Science University
2018
Senju Pharmaceutical (Japan)
2013-2014
Ibaraki University
2013
Saga University
2009
Showa University
1997
Abstract Background Angiotensin II (Ang II) plays a critical role in the progression of kidney disease. In addition to its direct signaling events, Ang transactivates epidermal growth factor receptor (EGFR) and causes renal injury. CD148 is transmembrane protein tyrosine phosphatase that dephosphorylates EGFR strongly inhibits activity. this study, we have asked if agonistic antibody 18E1 mAb attenuates injury induced by chronic infusion explore therapeutic application. Methods Hypertensive...
IgA nephropathy (IgAN) is characterized by mesangial deposition of IgA1 and galactose-deficient expected to play a pathogenic role. However, the identity receptor for still controversial. Hence, aim this study was explore IgA1. Human monoclonal treated with exoglycosidase FITC-conjugated control, asialo- agalactosyl-IgA1 used as probe detect in cultured human cells. Tumor necrosis factor-α or transforming growth factor-β1 treatment accelerated IgA1-binding on cells, these effects were...
Abstract Leptin, one of the typical adipokines, is reported to promote T h 17 cell responses and enhance production proinflammatory cytokines. To clarify role leptin in regulation IL-23/IL-17 axis development kidney disease, we used a murine model nephrotoxic serum (NTS) nephritis (NTN). Sheep NTS was administered wild-type C57BL/6J mice food-restricted, leptin-deficient C57BL/6J- ob/ob (FR- ) after preimmunization with sheep IgG. The profile mRNA expression relevant helper lymphocytes...
It is well known that atrophic renal changes are associated with chronic kidney disease (CKD) progression, but conventional diagnostic imaging methods such as noncontrast-enhanced computed tomography and magnetic resonance (MRI) have been insufficient for precisely assessing function because they cannot clearly distinguish between the medulla cortex. Hence, here we used steady-state free precession (SSFP) MRI a spatially selective inversion recovery (IR) pulse to improve visibility...
Tubular atrophy and fibrosis are pathological changes that determine the prognosis of kidney disease induced by acute injury (AKI). We aimed to evaluate multiple magnetic resonance imaging (MRI) parameters, including pool size ratio (PSR) from quantitative magnetization transfer, relaxation rates, measures spin-lock (
Prolactin is a polypeptide hormone with over 300 separate biologic activities. Its serum level increased during pregnancy and lactation, it has been reported that lactation affect drug steroid metabolism in mice humans. Several studies or influences liver cytochrome P450 (P450) expression its activity, affecting the biosynthesis of steroids xenobiotics through growth sex hormones; however, role prolactin as regulator <i>P450</i> not elucidated so far. In present study, we focused on...
BACKGROUND:Mesenteric panniculitis (MP) is an idiopathic chronic inflammatory condition of the mesentery. The main symptoms include abdominal pain, distention, weight loss, fever, nausea, and vomiting. patients also present with chylous ascites in 14% cases pleural effusion (CPE) very rare occasions. Despite previous view excellent prognosis MP, two recent papers reported several fatal cases. However, there are still only a few autopsy case reports that describe macroscopic histological...
We studied the l-type isoproterenol inhalation therapy for patients with severe asthmatic attacks who were admitted at Department of Allergy National Children's Hospital from 1981 to 1991. One hour after therapy, statistically significant effects noted regard status. Moreover, no side effect was found amoung subjects. From these data, is thought be effective attacks.
We evaluated the use of quantitative MRI relaxometry, including dispersion spin-lock relaxation with different locking fields, for detecting and assessing tubular dilation fibrosis in a mouse model unilateral ureter obstruction (UUO). C57BL/6 J BALB/c mice that exhibit levels renal after UUO were subjected to MR imaging at 7 T. Mice imaged before surgery, 5, 10 15 days surgery. acquired maps rates fit R
ABSTRACT Background Activated macrophages, pivotal for driving the immune response in sepsis, express high levels of CD38. Although circulating its ligand, CD31, increase functions CD38 and ligation remain elusive. This study aimed to elucidate impact on sepsis using single-cell single-nucleus RNA sequencing (scRNA-seq snRNA-seq, respectively) identify a novel therapeutic target severe sepsis. Methods We performed scRNA-seq analysis mouse peritoneal cells precisely cell types exhibiting...
Hypercalcemia is a significant complication in cancer patients, primarily caused by parathyroid hormone-related peptide (PTHrP) and, rarely, hormone (PTH) production from tumors. We report case of severe hypercalcemia woman with uterine who exhibited elevated PTH and PTHrP levels. Surgical intervention revealed dedifferentiated endometrial carcinoma. Postoperatively, levels normalized but subsequently increased due to metastases. A molecular analysis confirmed the expression gene protein...
Abstract Background Massive proteinuria, dyslipidemia, and hypoalbuminemia induced by nephrotic syndrome (NS) secondarily affect tubular cells. We conducted an RNA sequencing (RNA-seq) analysis using a mouse model of focal segmental glomerulosclerosis to clarify the impact NS on Methods used transgenic mice expressing hCD25 in podocytes (Nep25) induce injecting human CD25-specific immunotoxin (LMB2) at dose 0.625 ng/g body weight. Seven days after LMB2 injection, we extracted from whole...
Background: Sodium magnetic resonance imaging can non-invasively assess sodium distribution, specifically concentration in the countercurrent multiplication system kidney, which forms a gradient from cortex to medulla, enabling efficient water reabsorption. This study aimed investigate whether detect changes concentrations under normal conditions mice and disease models such as mouse model with diabetes mellitus. Methods : We performed proton nuclear using 9.4-T vertical standard-bore...