A5045890370- Complementary and Alternative Medicine Studies
- Liver Disease Diagnosis and Treatment
- Pharmacy and Medical Practices
- Child and Adolescent Psychosocial and Emotional Development
- Pharmacology and Obesity Treatment
- Folate and B Vitamins Research
- Antimicrobial agents and applications
- Pharmacological Effects of Natural Compounds
- Consumer Attitudes and Food Labeling
- Wound Healing and Treatments
- Behavioral and Psychological Studies
- Cancer, Lipids, and Metabolism
- Pharmacogenetics and Drug Metabolism
- Liquid Crystal Research Advancements
- Ginkgo biloba and Cashew Applications
- Pancreatic and Hepatic Oncology Research
- Nutritional Studies and Diet
- Early Childhood Education and Development
- Vitamin C and Antioxidants Research
- Pancreatitis Pathology and Treatment
- Pneumonia and Respiratory Infections
- Lipoproteins and Cardiovascular Health
- Dental Anxiety and Anesthesia Techniques
- Diet and metabolism studies
- Chemical Synthesis and Analysis
Hiroshima University
1979-2025
University of Shizuoka
2022-2024
Shizuoka General Hospital
2020-2023
Kyoritsu Women's University
2023
Showa University Koto Toyosu Hospital
2022
Showa University
2022
Shizuoka University
2021
National Defense Medical College
2017-2020
National Institute of Biomedical Innovation, Health and Nutrition
2015-2020
Keio University
2020
To clarify the prevalence of dietary supplement use among college students, we conducted Internet-based nationwide questionnaire surveys with 157,595 Japanese students aged between 18 to 24 years old who were registrants Macromill Inc. (Tokyo, Japan). Among 9066 respondents (response rate 5.8%), 16.8% currently using supplements. The did not differ significantly males (17.1%) and females (16.7%). However, it increased according their grade (13.1% 20.5%), was higher in medical pharmaceutical...
Recently, people have used dietary supplements not only for nutritional supplementation, but also treatment of their diseases. However, use to treat diseases, especially with medications, may cause health problems in patients. In this study, we investigated patients Japan. This survey was conducted from January December 2012, and completed by 2732 people, including 599 admitted patients, 1154 ambulatory 979 healthy subjects who attended a seminar about supplements. At the time questionnaire,...
Background and Purpose— A public registration system for intractable diseases was started in Japan 1972 to investigate the etiology pathogenesis of while reducing out-of-pocket medical expenses on patients. The goal this study epidemiology clinical characteristics Moyamoya disease using data from applications submitted between 2004 2008. Methods— In addition demographic factors such as onset age family history, we evaluated presentation type, imaging findings, symptoms, functioning...
Analyzing real-world data, including health insurance claims, may help provide insights into preventing and treating various diseases. We developed a database covering Shizuoka Prefecture (Shizuoka Kokuho Database [SKDB]) in Japan, which included individual-level linked data on health- care-insurance claims checkup results.Anonymized (National Health Insurance [age <75 years] Latter-Stage Elderly Medical Care System ≥75 years]), care insurance, subscriber lists, annual checkups, all dates of...
Background Although structural magnetic resonance imaging (MRI) studies have repeatedly demonstrated regional brain abnormalities in patients with schizophrenia, relatively few MRI-based attempted to distinguish between first-episode schizophrenia and healthy controls. Method Three-dimensional MR images were acquired from 52 (29 males, 23 females) 40 (22 18 subjects. Multiple measures (regional volume cortical thickness) calculated by a fully automated procedure used for group comparison...
Abstract Retroviral reverse transcription is accomplished by sequential strand-transfers of partial cDNA intermediates copied from viral genomic RNA. Here, we revealed an unprecedented role 5′-end guanosine (G) HIV-1 RNA for transcription. Based on current consensus initiation site, transcripts possess a single G at 5′-ends (G1-form). However, found that with additional Gs (G2- and G3-forms) were abundantly expressed in infected cells using alternative sites. The G2- G3-forms also detected...
Japan promotes research related to intractable diseases and financially supports patients with these diseases. Intractable are designated as those that fulfill the following criteria: (1) rarity (affecting less than 0.1% of population in Japan), (2) unknown etiology, (3) lack effective treatment, (4) necessity long-term (5) existence objective diagnostic criteria not necessarily equal rare other countries. The construction a national database is required promote clarify pathogenesis develop...
In chronic kidney disease (CKD) patients, accumulation of uremic toxins is associated with cardiovascular risk and mortality. One the hallmarks disease-related intravascular macrophage inflammation, but mechanism reaction these not completely understood. Macrophages differentiated from THP-1 cells were exposed to indoxyl sulfate (IS), a representative toxin, changes in inflammatory cytokine production intracellular signaling molecules including interleukin (IL)-1, aryl hydrocarbon receptor...
In the Japanese health checkup system for older adults aged ≥75 years, Questionnaire Medical Checkup of Old-Old (QMCOO) was adopted after 2020. However, prognostic significance this questionnaire incidence functional disability is uncertain. The current study aimed to validate QMCOO, and develop a simple risk score by analyzing insurance claims data including annual data. This included 111 282 75-90 years who did not receive long-term care services at baseline. period between earliest day...
The accumulation of metabolic risk factors, namely high blood pressure, hyperlipidemia, and hyperglycemia, has been associated with cardiovascular diseases. However, little evidence is available on the prognostic significance factor in nonobese individuals. This study investigated this issue by analyzing prefecture-wide health checkup insurance data Japan. We analyzed from 366,881 adults aged 40-74 years who were enrolled National Health Insurance, excluding those experienced a stroke or...
Porphyromonas gingivalis, the bacterium responsible for periodontitis, produces several pathogenic factors, including methyl mercaptan, which contribute to disease. Kouboku (Magnoliaceae), a Chinese herbal medicine, has been shown suppress mercaptan production from P. gingivalis. In this study, we investigated inhibitory effect of on production, biofilm formation, gingivalis-host cell interactions, and its potential synergistic antibacterial with antibiotics. Five standard five clinically...
We previously reported that some patients used dietary supplements with their medication without consulting physicians. Dietary and medicines may interact each other when concomitantly, resulting in health problems. An Internet survey was conducted on 2109 people who concomitantly took order to address supplement usage regularly take Japan. A total of 1508 (two admitted 1506 ambulatory patients) 601 non-patients, were not physicians, participated this study. Purpose for use different among...
Non-alcoholic steatohepatitis (NASH) is a globally recognized liver disease. A methionine- and choline-deficient diet used to induce NASH in mice; however, this also causes severe body weight loss. To resolve issue, we examined the effects of methionine content high-fat (HFCD) on development mice.C57BL/6J mice (male, 10 weeks age) were fed an L-amino acid rodent (control) diet, (HF) or HFCD containing various amounts (0.1-0.6% (w/w)) for 12 weeks. Plasma lipid levels, hepatic inflammatory...
The prevalence of dietary supplements has increased in Japan, and, as a consequence, the adverse events associated with supplement use have become more prominent. Severe must be reported to Japanese government via public health centers. However, number cases is limited. To clarify this discrepancy, we conducted an internet questionnaire, and surveyed how consumers, physicians pharmacists acted when they or their patients developed due use. This study was completed by 2732 515 physicians,...
This study was conducted to examine the characteristics and use of dietary supplements by preschool children in Japan. A survey among 2,125 parents discover status supplement their attitudes towards children. Logistic regression models were used determine which predict this population. For detailed characterization, child users also categorized as either vitamins minerals only or other components. non-user children, parent's knowledge toward for investigated. Fifteen percent had supplements....
Background: Thirty-three Japanese children and adolescents diagnosed with an anxiety disorder participated in individual or group Cognitive Behaviour Therapy (CBT) that was modelled after evidence-based intervention programs developed Western countries. Method: The treatment consisted of: (a) building rapport education; (b) identifying emotions recognizing cognitive self-talk; (c) challenging anxious (d) developing hierarchy vivo exposures; (e) planning for future challenges. Results: Three...
We examined the effectiveness of localized administration fibroblast growth factor-2 containing low-molecular-weight heparin/protamine nanoparticles (FGF-2&LMWH/P NPs) on apoptosis in vivo and healing radiation-induced skin injury a rat model. FGF-2 binds onto LMWH/P NPs, which can significantly enhance stabilize as local carrier. X-irradiation at dose 25 Gy was administered to lower part back (using lead sheet with two holes) 1 h before FGF-2&LMWH/P NPs. Cutaneous full-thickness defect...