A5025308054- Nutrition and Health in Aging
- Frailty in Older Adults
- Nutritional Studies and Diet
- Blood Pressure and Hypertension Studies
- Dementia and Cognitive Impairment Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Chronic Lymphocytic Leukemia Research
- Hormonal Regulation and Hypertension
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Function and Risk Factors
- Lymphoma Diagnosis and Treatment
- Cardiovascular Health and Disease Prevention
- Body Composition Measurement Techniques
- Adrenal and Paraganglionic Tumors
- Peroxisome Proliferator-Activated Receptors
- Solar Radiation and Photovoltaics
- Liver Disease Diagnosis and Treatment
- Muscle Physiology and Disorders
- Genomics and Phylogenetic Studies
- Renin-Angiotensin System Studies
- Health disparities and outcomes
- Adrenal Hormones and Disorders
- Atherosclerosis and Cardiovascular Diseases
- Heart Rate Variability and Autonomic Control
- Eosinophilic Disorders and Syndromes
Osaka University
2016-2025
Iwate Medical University
2011-2025
Shinshu University
2024
The University of Texas Southwestern Medical Center
2024
Kobe Asahi Hospital
2024
Osaka Health Science University
2023
Berkeley Public Health Division
2023
University of California, Berkeley
2023
Osaka University of Human Sciences
2021-2023
Tokyo Metropolitan Institute of Gerontology
2021-2023
Angiotensin-converting enzyme 2 (ACE2) is highly expressed in the kidney and converts angiotensin (Ang) II to Ang-(1–7), a renoprotective peptide. Urinary ACE2 has been shown be elevated patients with chronic disease. However, effects of antihypertensive agents on urinary remain unclear. Of participants Tanno-Sobetsu cohort study 2011 (n = 617), subjects no medication 101) hypertensive treated agents, including calcium channel blockers amlodipine long-acting nifedipine; ACE inhibitor...
The effects of salt reduction and adequate nutrition intake among older adults with physical frailty remain controversial. Therefore, the present study investigated whether association between daily blood pressure community-dwelling adults, including very old people, based on their status. This cross-sectional used data from SONIC study, a cohort collected 2010 2012. Daily was estimated brief self-administered diet history questionnaire. Participants were stratified by groups use...
Quercetin is a promising food component, which can prevent lifestyle related diseases. To understand the dietary intake of quercetin in subjects population-based cohort study and Japanese population, we first determined content foods available market during June July or near town Hokkaido, Japan. Red leaf lettuce, asparagus, onions contained high amounts derivatives. We then estimated daily by 570 residents aged 20–92 years old using frequency questionnaire (FFQ). The average median intakes...
Objective Fatty acid-binding proteins (FABPs) are a family of 14-15-kDa proteins, and some FABPs have been to be used as biomarkers tissue injury by leak from cells. However, recent studies shown that can secreted cells into circulation. Here we examined determinants roles circulating in general population. Methods From the database Tanno-Sobetsu Study, study with population-based cohort design, data 2011 for 296 subjects on no medication were retrieved, FABP1∼5 their serum samples assayed....
Objectives To evaluate the impact of dietary sodium and potassium (Na–K) ratio on mortality from total subtypes stroke, cardiovascular disease (CVD) all causes, using 24-year follow-up data a representative sample Japanese population. Setting Prospective cohort study. Participants In 1980 National Cardiovascular Survey, participants were followed for 24 years (NIPPON DATA80, Integrated Project Observation Non-communicable Disease And its Trends in Aged). Men women aged 30–79 without...
IntroductionWe previously reported an interim analysis of the DADI (dasatinib discontinuation) trial. The results showed that 48% patients with chronic myeloid leukemia in phase who maintained a deep molecular response (DMR) for ≥ 1 year could discontinue second- or subsequent-line dasatinib treatment safely at median follow-up 20 months. However, from longer periods would be much more useful clinical perspective.Patients and MethodsThe trial was prospective, multicenter conducted Japan....
ObjectivesType 2 diabetes is a risk factor for sarcopenia. Evidence on the prevention of sarcopenia using blood glucose–lowering therapy limited. We aimed to examine relationship between changes in glycemic control and effect antidiabetic agents against patients with type diabetes.DesignWe conducted an observational longitudinal study.Setting ParticipantsIn total, 588 Japanese ongoing multicenter study completed 1-year follow-up measurements clinical data.MethodsThe data set Multicenter...
This study investigated the association between green tea or coffee consumption with cerebral white matter lesions and hippocampal total brain volumes among 8766 community-dwelling participants recruited from Japan Prospective Studies Collaboration for Aging Dementia 2016 2018. A Food Frequency Questionnaire was used to assess consumption, whereas magnetic resonance imaging performed lesions, volume, volume. Multivariable-adjusted analysis revealed significant correlations fewer higher no...
PURPOSE: t(8;14)(q24;q32) and/or c-MYC/immunoglobulin heavy-chain (IGH) fusion gene have been observed not only in Burkitt’s lymphoma (BL) but also a proportion of non-BL, diffuse large-cell B-cell type (DLCL). We explored molecular features DLCL with c-MYC/IGH and the impact this genetic abnormality on clinical outcome DLCL. PATIENTS AND METHODS: A total 203 cases non-BL were studied. Genomic DNA extracted from tumor tissues was subjected to long-distance polymerase chain reaction (LD-PCR)...
The nurses working in psychiatric hospitals and wards are prone to encounter completed suicides. research was conducted examine post-suicide stress the availability of suicide-related mental health care services education.Experiences with inpatient suicide were investigated using an anonymous, self-reported questionnaire, which was, along Impact Event Scale-Revised, administered 531 nurses.The rate who had encountered patient 55.0%. mean Scale-Revised (IES-R) score 11.4. proportion...
Fatty acid-binding protein 4 (FABP4) is expressed in adipocytes, and elevated plasma FABP4 level associated with obesity-mediated metabolic phenotype. Postprandial regulation secretory signaling of has been investigated.Time courses levels were examined during an oral glucose tolerance test (OGTT; n=53) or a high-fat meal eating (n=35). Effects activators inhibitors adenyl cyclase (AC)-protein kinase A (PKA) guanylyl (GC)-protein G (PKG) on secretion from mouse 3T3-L1 adipocytes...
Fatty acid-binding protein 4 (FABP4) is expressed in both adipocytes and macrophages. Recent studies have shown secretion of FABP4 from association elevated serum level with obesity, insulin resistance, hypertension, atherosclerosis. However, little known about role cardiac function.From the database Tanno-Sobetsu Study, data for 190 subjects (male/female: 82/108) who were not treated any medication underwent echocardiography 2011 or 2012 retrieved analyses relationships between...
Abstract In recent years, the association between neuroinflammatory markers and dementia, especially Alzheimer’s disease (AD), has attracted much attention. However, evidence for relationship serum-hs-CRP dementia including AD are inconsistent. Therefore, relationships of serum high-sensitivity CRP (hs-CRP) with regions interest brain MRI were investigated. A total 11,957 community residents aged 65 years or older recruited in eight sites Japan (JPSC-AD Study). After applying exclusion...
Two propionate-producing strains (Wd(T) and Wf) that were isolated anaerobically from plant residue of irrigated rice-field soil in Japan characterized phenotypically phylogenetically. The growth rate strain Wd(T) was very slow basal medium, but both propionate production stimulated significantly by the addition cyanocobalamin. Strain Wf grew well medium produced substantial amounts fermentation products, including propionate. Other phenotypic phylogenetic characteristics two isolates almost...
OBJECTIVE Associations between HbA1c and cardiovascular diseases (CVD) have been reported mainly in Western countries. It is not clear whether measurements are useful for assessing CVD mortality risk East Asian populations. RESEARCH DESIGN AND METHODS The death was evaluated a large cohort of participants selected randomly from the overall Japanese population. A total 7,120 (2,962 men 4,158 women; mean age 52.3 years) free previous were followed 15 years. Adjusted hazard ratios (HRs) 95% CIs...
Recent Western studies show an inverse association between milk and dairy product intake cardiovascular disease (CVD). We studied the consumption of products CVD death in Japan.Men women aged 30 years or older were followed for 24 years. All had participated a national nutrition survey 300 health districts throughout Japan 1980. The Cox proportional hazards model was used to assess mortality risk according tertiles intake, with high group as reference. Hazard ratios (HRs) per 100-g/day...
Abstract Fatty acid-binding protein 4 (FABP4) is secreted from adipose tissue and acts as an adipokine, elevated circulating FABP4 level associated with metabolic disorders atherosclerosis. However, little known about the causal link between mortality in a general population. We investigated relationship concentration including cardiovascular death during 12-year period subjects of Tanno-Sobetsu Study, population-based cohort (n = 721, male/female: 302/419). at baseline was significantly...
Aim We carried out a randomized controlled trial using ipragliflozin. analyzed changes in diastolic function echocardiography patients with type 2 diabetes and heart failure preserved ejection fraction. Methods an open‐label, multicenter, randomized, two‐arm interventional trial. A total of eligible 68 participants were randomly assigned into two groups (ipragliflozin group n = 36; conventional treatment 32). Primary end‐points the change E / e ' '. Secondary other parameters...
The associations among cognitive function, hypertension, and dyslipidemia in older adults are controversial. Therefore, we investigated the decline, dyslipidemia, their combination community-dwelling people 70s, 80s, 90s long-term observational Septuagenarians, Octogenarians, Nonagenarians, Investigation with Centenarians (SONIC) study. We administered Montreal Cognitive Assessment Japanese version (MoCA-J) by trained geriatricians psychologists, conducted blood testing pressure (BP)...
The serum creatinine/cystatin C ratio (CCR) or sarcopenia index is considered a useful marker of muscle mass. However, its usefulness in late-stage older adults remains unclear. We aimed to determine the CCR as an indicator community-dwelling Japanese aged >75 years.
Aim Vitamin D (VD) affects skeletal muscles. The high prevalence of VD deficiency in Japan may lead to decreased muscle mass and strength, increasing the sarcopenia. Therefore, we aimed investigate association between serum levels indices a Japanese community‐dwelling older population. Methods We extracted data from Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians (SONIC) study. analyzed for participants 70s 90s age groups. Skeletal index (SMI) using bioimpedance...