A5007458112- Migraine and Headache Studies
- Folate and B Vitamins Research
- Neurological Disorders and Treatments
- Acute Ischemic Stroke Management
- Peripheral Neuropathies and Disorders
- Parkinson's Disease Mechanisms and Treatments
- Trigeminal Neuralgia and Treatments
- Alzheimer's disease research and treatments
- Autoimmune Neurological Disorders and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Hereditary Neurological Disorders
- Genetic Neurodegenerative Diseases
- Esophageal and GI Pathology
- Neuroscience of respiration and sleep
- Ophthalmology and Eye Disorders
- Dementia and Cognitive Impairment Research
- Glycogen Storage Diseases and Myoclonus
- Advanced MRI Techniques and Applications
- Neurological disorders and treatments
- Iron Metabolism and Disorders
- Neurological Complications and Syndromes
- Cancer Treatment and Pharmacology
- Cerebral Venous Sinus Thrombosis
- Myasthenia Gravis and Thymoma
- Sympathectomy and Hyperhidrosis Treatments
National Institute of Technology, Matsue College
2025
National Hospital Organization
2018-2024
National Center for Geriatrics and Gerontology
2023
Tottori University
2009-2019
Institute of Neurological Sciences
1992-2009
Kitasato University Hospital
1994
Kitasato University East Hospital
1994
This study investigated the association between green tea or coffee consumption with cerebral white matter lesions and hippocampal total brain volumes among 8766 community-dwelling participants recruited from Japan Prospective Studies Collaboration for Aging Dementia 2016 2018. A Food Frequency Questionnaire was used to assess consumption, whereas magnetic resonance imaging performed lesions, volume, volume. Multivariable-adjusted analysis revealed significant correlations fewer higher no...
Objectives.—To determine prevalence and characteristics of migraine in Japan, to investigate use medical care whether food preference is associated with risk migraine. Methods.—Structured questionnaires were given all adult residents (N = 5758; 2681 men 3077 women) Daisen, a rural community western Japan. Second questionnaires, specific headache, 1628 headache. A telephone survey was also carried out. Statistical Packages for the Social Sciences analyzed data. Results.—The 1‐year 2.3%...
Abstract Objective Migraine with aura is associated increased risk of stroke. The MTHFR C677T genotype has been migraine in selected clinical samples and elevated homocysteine, a factor for We assessed the association variant mediating effect cardiovascular factors metabolic markers status. Methods compared adult migraineurs (MA; n = 187), without (MO; 226), nonmigraineurs (n 1,212) from population‐based Genetic Epidemiology study. Results Compared wild‐type genotype, T/T was odds MA (odds...
Increased homocysteine levels are associated with various pathological conditions in humans, including stroke and cardiovascular disorders. Homocysteine acts as an excitatory amino acid vivo may influence the threshold of migraine headache. Frosst et al. [1995] reported association between homozygous C677T mutation 5,10-methylenetetrahydrofolate reductase (MTHFR) gene serum levels. This study was designed to determine prevalence MTHFR Japanese patients tension-type headache (TH)....
Substance P (SP), calcitonin gene-related peptide (CGRP), and angiotensin converting enzyme (ACE) may have roles in trigeminovascular nociceptive mechanisms. We investigated interictal levels of SP, CGRP, ACE activity, their correlation, a sample migraineurs. Forty-one patients suffering from migraine with aura (MA), 54 without (MO), 52 non-headache subjects (controls) participated this study. Blood samples were collected cubital veins. Plasma SP CGRP measured by immunoassay. activities...
Abstract In recent years, the association between neuroinflammatory markers and dementia, especially Alzheimer’s disease (AD), has attracted much attention. However, evidence for relationship serum-hs-CRP dementia including AD are inconsistent. Therefore, relationships of serum high-sensitivity CRP (hs-CRP) with regions interest brain MRI were investigated. A total 11,957 community residents aged 65 years or older recruited in eight sites Japan (JPSC-AD Study). After applying exclusion...
<b><i>Article abstract</i></b> Plasma homocysteine and cysteine levels were measured in 90 patients with PD the MTHFR C677T (T/T) genotype. The authors found that of homocysteine—a possible risk factor for vascular disease—were elevated by 60% levodopa-treated PD, most marked elevation occurring T/T Cysteine subjects did not differ from control subjects. In genotype patients, folate inversely correlated. Increased might be related to levodopa, genotype, PD.
<i>Background/Aim:</i> To determine the prevalence and incidence of Parkinson’s disease (PD) compare them with results from our previous studies. <i>Methods:</i> We examined epidemiological characteristics PD patients using a service-based study in Yonago City, door-to-door Daisen Town. The days were April 1, 2004 Yonago, 2003 Daisen. <i>Results:</i> In we identified 254 patients. crude was 180.3 (95% CI, 158.1–202.4) per 100,000 population. adjusted 145.8...
Abstract Background Progressive supranuclear palsy ( PSP ) is a neurodegenerative disorder that sometimes confused with Parkinson's disease, multiple system atrophy, and other disorders. The typical clinical features are categorized as Richardson's syndrome RS ), but subtypes include ‐parkinsonism ‐P) ‐pure akinesia gait freezing ‐ PAGF ). In this study, we determined the prevalence of in Japanese rural area compared to our previous 1999 report. Methods We collected data Yonago City from...
Abstract The vestibulospinal system was evaluated using a stabilometric method in patients with migraine and episodic tension‐type headache during headache‐free periods. Migraine often complain of dizziness or vertigo attacks some exhibit these symptoms between attacks. Computerized static stabilometry is reliable non‐invasive technique to evaluate the equilibrium function various diseases. subjects consisted 21 migraine, 12 and, age‐ sex‐matched controls. We performed two sets measurements...
<h3>Background and Objectives</h3> Epidemiologic evidence has shown that social isolation, a low frequency of contact with others, is associated the risk dementia late-life depressive symptoms. Therefore, we hypothesized may be involved in brain atrophy, symptoms play some role this relationship. We aimed to evaluate association between volumes various regions assess extent which mediate these relationships from large population-based multisite cohort study. <h3>Methods</h3> Dementia-free...
To clarify the characteristics of Japanese patients with frontotemporal dementia (FTD), we have established a nationwide multicenter registry named Frontiers Time course and Living specimen Disease-modifying therapy development in FTLD (FTLD-J). ensure diagnostic consistency, implemented case review meetings evaluated their utility. Between February 2016 August 2024, 269 behavioral variant FTD (bvFTD), semantic (SD), or progressive nonfluent aphasia (PNFA) were registered. Fifteen meetings,...
Superoxide dismutase (SOD) is a radical-scavenging enzyme. We determined Cu, Zn-SOD concentrations and activities in platelets from subjects with migraine tension-type headaches. Thirty without aura (MWoA) patients, 9 (MWA) 53 headache patients were selected for study. healthy volunteers composed the control group. Concentrations of platelet SOD using enzyme-linked immunosorbent assay techniques. The activity was by measuring reductivity nitroblue tetrazolium. Low found MWA MWoA. Platelet...
A 29-year-old man developed acute cerebellar ataxia following Epstein-Barr virus infection. Serum IgG and IgM antibodies reacted with both nuclear cytoplasmic elements of neurons. Western blot revealed binding to the 34- 29-kd bands 44-, 37-, bands. The reactivity gradually reduced. There was no identifiable neoplasm improved. These findings suggest a role for autoimmune mechanisms in pathogenesis ataxia.
Abstract International Headache Society published the Classification of Disorders 2nd Edition (ICHD‐II) in 2004. In response to this development, “Clinical Practice Guideline for Chronic Headache” was compiled Japan by Study Group Clinical Development. 2006, book entitled “The (edited Japanese Society)” as first edition. As triptans have become widely used, clinical practice chronic headache has also been changed and there a need revise Essentially based on edition, new guideline added...
Abstract Objectives To assess the impacts of social situation changes due to coronavirus disease 2019 (COVID-19) pandemic on headache-related disability and other symptoms in patients with migraine Japan. Methods We conducted a multicentre, cross-sectional study including 659 outpatients diagnosed by headache specialists. The participants were asked about first wave COVID-19 disability, days, intensity, stress, physical activity, hospital access their work home lives. For total Migraine...
Aim An association between body mass index ( BMI ) and stroke outcome have been reported, but the results are controversial. The aim of present study was to evaluate whether is associated with ischemic outcome. Methods Consecutive Japanese acute patients were analyzed. categorized as underweight <18.5 kg/m 2 ), normal weight (18.5–24.9 obese (≥25 ). short‐term long‐term outcomes examined. Short‐term evaluated using modified Rankin scale score at hospitalization discharge; ≥3 defined a...
To clarify whether the circadian rhythm of heart rate variability parameters can be identified in patients with migraine during a headache-free period and to identify any specific pattern variability, using time-domain spectral analysis cosinor normal daily activity.Forty-eight-hour Holter electrocardiograms were recorded for 27 periods 24 healthy controls free activity. The rhythms fluctuation parameters, that is, mean interval, standard deviation, root-mean-square successive differences...
To identify determinants of recurrence after ischemic stroke in the Japanese population.We enrolled 885 patients with acute that had been admitted to our community hospitals. A total 831 cases were followed for 1 year index stroke. Patients assigned one subtype groups based on NINDS Stroke Data Bank criteria.Rates significantly different among groups: 14.4% cardioembolic infarction, 7.3% atherothrombotic infarction (ATI), 6.2% lacunar (LI) and 7.8% uncertain cause. Previous history was...