A5073780855- Alzheimer's disease research and treatments
- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Migraine and Headache Studies
- Dementia and Cognitive Impairment Research
- Mitochondrial Function and Pathology
- Amyotrophic Lateral Sclerosis Research
- Neurological diseases and metabolism
- Neurological disorders and treatments
- Cholinesterase and Neurodegenerative Diseases
- Cerebrovascular and genetic disorders
- Metabolism and Genetic Disorders
- Asthma and respiratory diseases
- Neurological Disorders and Treatments
- Health, Environment, Cognitive Aging
- Hereditary Neurological Disorders
- Menopause: Health Impacts and Treatments
- Nuclear Receptors and Signaling
- Ion channel regulation and function
- Estrogen and related hormone effects
- Trigeminal Neuralgia and Treatments
- Pediatric health and respiratory diseases
- Folate and B Vitamins Research
- Neurological Disease Mechanisms and Treatments
- Microbial Metabolic Engineering and Bioproduction
National Hospital Organization
2010-2024
Tsuchiura Kyodo General Hospital
2013
Tottori University
2000-2012
Institute of Neurological Sciences
1996-2007
Tohoku Medical and Pharmaceutical University
2007
University of Toyama
2007
Koga Hospital
1999-2000
Objectives.—To determine prevalence and characteristics of migraine in Japan, to investigate use medical care whether food preference is associated with risk migraine. Methods.—Structured questionnaires were given all adult residents (N = 5758; 2681 men 3077 women) Daisen, a rural community western Japan. Second questionnaires, specific headache, 1628 headache. A telephone survey was also carried out. Statistical Packages for the Social Sciences analyzed data. Results.—The 1‐year 2.3%...
A meiotic fine structure map of the gal4 locus was constructed, which extended over 0.44 units on chromosome (units in percent frequency supposed recombination). Several nonsense mutations (four UAA and two UGA [gal4-62 gal4-69]) were placed at various sites map. In reversion experiments with 20 independently isolated mutants, only gal4-62 gal4-69 alleles, are located same site map, could revert to overcome superrepression gal80s-1 spontaneously a approximately 4 x 10(-7). Secondary...
Abstract Huntington's Disease–like 2 (HDL2) is a progressive, autosomal dominant, neurodegenerative disorder with marked clinical and pathological similarities to disease (HD). The causal mutation CTG/CAG expansion on chromosome 16q24.3, in variably spliced exon of junctophilin‐3. frequency HDL2 was determined nine independent series patients referred for HD testing or selected the presence an HD‐like phenotype North America Japan. repeat length, ancestry, age onset all American cases were...
The association between the estrogen receptor (ER-alpha) gene and dementia was examined in 223 patients with Alzheimer's disease (AD), 66 vascular (VD), 17 alcohol-associated (ALD) 134 healthy elderly control subjects. PvuII XbaI restriction fragment length polymorphisms of ER-alpha were represented as Pp (PvuII) Xx (XbaI), capital letters signifying absence sites small presence sites. We found that frequency P allele X late-onset AD (LOAD) group (P 0.51, 0.30) significantly higher than...
Abstract There have been few reports of the prevalence progressive supranuclear palsy (PSP): present study examines its in Japan and compares findings with those Europe United States. The per 100,000 was 5.82 (men, 9.14; women, 2.75), 95% confidence interval 1.78 to 9.86 1.82–16.47; −1.08–6.65). Our data were comparable studies © 2004 Movement Disorder Society
Apolipoprotein E σ4 allele (ApoE σ4) is associated with Alzheimer’s disease (AD) in familial and sporadic cases, but the associations of ApoE vascular dementia (VD) and/or ischemic cerebrovascular (ICVD) are still controversial. To clarify polymorphism AD, VD ICVD Japanese, we examined samples 255 patients 87 VD, 123 ICVD, as compared 117 age-matched healthy control subjects (CTL). The frequency was significantly higher group (0.21), (0.15) well AD (0.26) than CTL (0.08). These findings...
<i>Background:</i> With the striking increase in number of elderly people Japan, dementia has not only become a medical but also social issue. <i>Methods:</i> We studied prevalence dementing disorders rural island town Japan (Ama-cho), using door-to-door 2-phase design. <i>Results:</i> Of 120 persons screened as having cognitive impairment, 104 were diagnosed dementia. The (cases/100 aged 65 years and older) was 11.0 for all types dementia, 7.0 Alzheimer’s...
Only a few prospective studies have determined which clinical symptoms and factors are associated with the disease severity of spinocerebellar ataxia type 6 (SCA6). A multicenter longitudinal cohort study was conducted to clarify both natural history SCA6 in Japan influencing progression. Patients were consecutively recruited between 2007 2008. Scores from Scale for Assessment Rating Ataxia (SARA) Barthel Index (BI) collected prospectively each year. Additionally, data intractable diseases...
Parkinson's disease (PD) is a common cause of dementia in the elderly. Dementia Alzheimer's (AD) and PD share biologic clinical features. The estrogen receptor (ER) gene one susceptibility genes for AD. In order to test hypothesis that overlap between AD may have genetic basis, we determined ER polymorphisms 13 patients with (PDD) (age +/- SD; 71.9 5.5 years), 71 without (PDND) (68.4 7.5 86 (76.8 8.0 years) 51 control subjects (CTL) (74.9 6.9 years). genotypes were classified as P or p...
Gastric cancer (GC) has benefited from treatment improvements such as minimally invasive surgery, molecular-targeted drugs, and immune check point inhibitors. However, the prognosis of advanced GC is still unfavorable. Minimally pre-treatment detection drug sensitivity (MI-PDDS) increasing importance in view improved chemotherapy. biopsy specimens are obtained with relative ease but have not been considered an appropriate source for generating cell lines because their minute amounts. We...
The development of a diagnostic marker for earlier and more accurate clinical diagnosis Alzheimer's disease (AD) is essential to identify AD patients during life unequivocally. purpose this study was investigate the basic performance significance tau level measurement in cerebrospinal fluid (CSF) using an enzyme-linked immunosorbent assay (ELISA) developed by Innogenetics. ELISA system showed reliable reproducibility good linearity. For studies, CSF samples from variety (n = 332) were...
We identify the prevalence and genetic features of Charcot-Marie-Tooth disease (CMT) in Yonago Sakaiminato, western Japan. From information registered records questionnaires, definite or candidate CMT patients were examined. Eleven families with 19 (7 female 12 male) identified was 10.8 per 100,000 April 2000. 6 showed a Thr124Met mutation MPZ gene, 2 duplication PMP22 gene suggested no abnormalities found families. To occurrence mildly affected CMT, exhaustive region-matched family study necessary.
In order to study progressive dementia in Alzheimer’s disease (AD) patients, we analyzed the gene expression of apolipoprotein E (apoE). ApoE mRNA level brains patients with AD was determined by reverse transcriptase-polymerase chain reaction (RT-PCR) method. genotype and promoter polymorphisms (–491A/T, Th1/E47cs) were PCR restriction fragment length polymorphism The apoE significantly higher group than control (p < 0.05). &#917;4 also that Our result did not indicate possibility...
Therapy for Parkinson''s disease (PD) has been progressing. However, the prognosis patients with PD is still unclear. We studied course of in San-in Area Japan over a long time period. The main purpose this study was to see whether there difference survival between and general population. Information on 114 deceased patients, who died 1989 1996, collected from hospitals belonging Tottori University Disease Epidemiology Study Group. Although duration illness prolonged, poorer than that most...
Abstract Background: The increasing number of patients with dementia in Japan, together the rapid aging society, is currently considered to have a substantial impact on Japan's medical, economic and sociological systems. Therefore, longitudinal estimation changes prevalence based accurate diagnostic evaluation has important implications. Methods: We undertook three separate epidemiological studies long‐term changes, 10 years apart (1980, 1990 2000), an elderly population using identical...
BackgroundzzLeber's hereditary optic neuropathy (LHON) is a mitochondrial disorder with nerve atrophy.Although there are no other associated neurological abnormalities in most cases of LHON, "LHON plus" have been reported.Case ReportzzThe proband was 37-year-old man who had visual and gait disturbances that first appeared at 10 years age.He showed horizontal gaze palsy, gaze-evoked nystagmus, dysarthria, cerebellar ataxia.Brain orbit MRI disclosed atrophy the cerebellum, degenerative changes...
We carried out two separate epidemiological studies on long-term changes, 10 years apart, the prevalence rate of dementia in elderly by same method for area Japan. also performed a genetic study patients with Alzheimer type (DAT) based studies. The number was much larger 1990 than 1980. Especially, mildly demented significantly 35 DAT did not show any mutations amyloid-β protein precursor, presenilin 1 and 2 genes. frequency apolipoprotein E (apo E) σ4 allele higher that control subjects (p...
We investigated the genetic association between intronic polymorphism in Presenilin-1 (PS-1) gene and patients with various types of dementia such as Alzheimer's disease (AD), vascular (VD) alcohol associated (ALD), Japanese population. Homozygosity for allele 1 PS-1 was significantly increased late-onset sporadic AD, but not early-onset familial VD ALD. When AD were divided on basis apolipoprotein E (APOE) genotype, homozygosity without APOE εe 4 allele, those allele. Intronic mutation may...