A5067641655- Sarcoma Diagnosis and Treatment
- Dysphagia Assessment and Management
- Cancer-related Molecular Pathways
- Molecular Biology Techniques and Applications
- Esophageal and GI Pathology
- Tracheal and airway disorders
- Cancer Genomics and Diagnostics
- Genomics and Chromatin Dynamics
- Mathematical Biology Tumor Growth
- Virus-based gene therapy research
- CAR-T cell therapy research
- MRI in cancer diagnosis
- Peptidase Inhibition and Analysis
- Protein Degradation and Inhibitors
- Bone Tumor Diagnosis and Treatments
- Colorectal Cancer Treatments and Studies
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Vascular Tumors and Angiosarcomas
- Emergency and Acute Care Studies
- Neuroendocrine Tumor Research Advances
- Cancer Research and Treatments
- Voice and Speech Disorders
- Neurofibromatosis and Schwannoma Cases
- Pleural and Pulmonary Diseases
University of Greenwich
2022-2025
Lewisham and Greenwich NHS Trust
2022-2025
Tochigi Cancer Center
2022-2025
Scientific Research WorkS Peer Support Group
2024-2025
Aso Iizuka Hospital
2017-2024
Queen Elizabeth Hospital
2022-2024
National Cancer Centre Japan
2021-2023
King's College Hospital NHS Foundation Trust
2023
National Cancer Research Institute
2021-2022
Hyogo Medical University
2020-2022
Esophageal squamous cancer (ESC) is one of the most aggressive tumors gastrointestinal tract. A combination chemotherapy and radiation therapy (CRT) has improved clinical outcome, but molecular background determining effectiveness remains unknown. NRF2 a master transcriptional regulator stress adaptation, gain of-function mutation in confers resistance to stressors including anticancer therapy. Direct resequencing analysis revealed that Nrf2 gain-of-function occurred recurrently (18/82, 22%)...
Debriefings give healthcare workers voice through the opportunity to discuss unanticipated or difficult events and recommend changes. The typical goal of routine debriefings has been improve clinical outcomes by learning discussion reflection then transferring that into practice. However, little research investigated effects on emotional experiences well-being workers. There is some evidence are a multi-faceted cost-effective intervention for minimising negative health outcomes, but their...
Little is known about the long-term and functional prognoses of older adults with pneumonia, which complicates their management. There a common belief that aspiration poor prognostic factor; however, diagnosis pneumonia (AP) lacks consensus criteria mainly based on clinical characteristics typical frailty syndrome. Therefore, prognosis AP may also be result rather than aspiration. This study investigated impact other factors in patients pneumonia.
Pneumonia is a common reason for admission afflicting frail older adults. Those who are the frailest more likely to be provided with diagnosis of aspiration pneumonia. This has no clear definition and clinical consensus. It therefore time stop attempting differentiate between pneumonia type use term frailty-associated
Human papillomaviruses (HPV) are believed to be the primary causal agents for development of cervical cancer, and deregulated expression two viral oncogenes E6 E7 in basal cells, mostly by integration, is considered a critical event disease progression. However, lines evidence suggest that, besides genes, additional host genetic alterations required cancer development. To directly test this hypothesis, we first transduced HPV16 with or without hTERT into several normal human keratinocytes...
The high‐risk human papillomavirus E6 proteins have been shown to interact with and lead degradation of PDZ ‐domain‐containing through its carboxy‐terminal motif. This ‐binding motif plays important roles in transformation cultured cells carcinogenesis E6‐transgenic mice. However, biological effects on the natural host not elucidated. We examined an vitro model for cervical cancer, which E7 together activated HRAS ( G 12V ) can induce tumorigenic normal keratinocytes. In this model, E6Δ151...
The p53 family member p63 is a master regulator of epithelial development. One its isoforms, DeltaNp63alpha, predominantly expressed in the basal cells stratified epithelia and plays fundamental role control regenerative potential integrity. In contrast to p53, rarely mutated human cancers, but it frequently overexpressed squamous cell carcinomas (SCC). However, functional relevance tumorigenesis remains largely unclear. We previously identified Notch1 gene as novel transcriptional target...
Gastric cancer (GC) has benefited from treatment improvements such as minimally invasive surgery, molecular-targeted drugs, and immune check point inhibitors. However, the prognosis of advanced GC is still unfavorable. Minimally pre-treatment detection drug sensitivity (MI-PDDS) increasing importance in view improved chemotherapy. biopsy specimens are obtained with relative ease but have not been considered an appropriate source for generating cell lines because their minute amounts. We...
Abstract Background Obstructive sleep apnea (OSA) occurs more commonly in asthma patients than the general population because these conditions share some comorbidities. In Japan, prevalence of OSA is reported to be approximately 20%; however, few reports have described patients. Furthermore, characteristics Japanese with and are not clear. Methods Adult were recruited from outpatient departments our institution between August 31, 2017, March 2019. all included patients, presence severity...
Older adults are susceptible to anticholinergic effects. Dysphagia and pneumonia associated with usage, though a definitive causative relationship has not been established. There is no effective way predict the prognosis of older pneumonia; therefore, this study investigates predictive value burden.
Older patients with pneumonia are commonly restricted from oral intake due to concerns towards aspiration. Eating and drinking acknowledged risks (EDAR) is a shared decision-making process emphasising patient comfort. As part of our project find the barriers facilitators EDAR, we aimed for this initial study see how frequently EDAR was selected in practice.
In older adults, community-acquired pneumonia (CAP) is often aspiration-related. However, as aspiration (AP) lacks clear diagnostic criteria, the reported prevalence and clinical management vary greatly. We investigated what factors appeared to influence diagnosis of AP non-AP in a setting reconsidered more clinically relevant approach. Medical records patients aged ≥75 years admitted with CAP were reviewed retrospectively. A total 803 (134 APs 669 non-APs) included. The group had...
Peritoneal dissemination is a critical prognostic factor in ovarian cancer. Although stabilized spheroid formation promotes cancer cell peritoneal cancer, the associated oncogenes are unknown. In this study, we assessed role of KRAS oncogene dissemination, focusing on stability cells condition, as well modulation intracellular signaling following transformation.We used ID8, murine line, and ID8-KRAS, an oncogenic (G12 V)-transduced ID8 line study. Spheroid-forming (3D) culture proliferation...
Human papillomaviruses (HPVs) are the primary causal agents for development of cervical cancer, and deregulated expression two viral oncogenes E6 E7 is considered to contribute disease initiation. Recently, we have demonstrated that transduction oncogenic HRAS (HRAS G12V ) MYC together with HPV16 E6E7 sufficient tumorigenic transformation normal human keratinocytes (HCKs). Here, show on background causes accumulation protein not only HCKs but also other cells, including tongue bronchial...
Abstract Cardiomyopathy and rapid progressive interstitial pneumonia ( IP ) are potentially fatal complications in polymyositis/dermatomyositis. We experienced a dermatomyositis patient with multiple adverse prognostic factors, complicating , macrophage activation syndrome MAS ), cardiomyopathy. improved strong immunosuppressive therapy, despite which cardiomyopathy developed. Therefore, we applied intravenous high‐dose immunoglobulin therapy IVI g), cardiac function dramatically. This is...
Abstract Translocation-related sarcomas (TRSs) harbor an oncogenic fusion gene generated by chromosome translocation and account for approximately one-third of all sarcomas; however, effective targeted therapies have yet to be established. We previously reported that a pan-phosphatidylinositol 3-kinase (PI3K) inhibitor, ZSTK474, was the treatment in phase I clinical trial. also demonstrated efficacy ZSTK474 preclinical model, particularly cell lines from synovial sarcoma (SS), Ewing’s (ES)...