A5060779010- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Surfactants and Colloidal Systems
- Diabetes Management and Research
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Organophosphorus compounds synthesis
- Nutrition and Health in Aging
- Phosphorus compounds and reactions
- Computational Fluid Dynamics and Aerodynamics
- Peripheral Artery Disease Management
- Vascular Procedures and Complications
- Immune Cell Function and Interaction
- Autoimmune Bullous Skin Diseases
- Advanced X-ray Imaging Techniques
- Environmental Chemistry and Analysis
- Sinusitis and nasal conditions
- Diet and metabolism studies
- Lipid Membrane Structure and Behavior
- Blood Pressure and Hypertension Studies
- Diabetic Foot Ulcer Assessment and Management
- Advanced X-ray and CT Imaging
- Particle Detector Development and Performance
- Aerodynamics and Acoustics in Jet Flows
Kanto Gakuin University
2024-2025
Fukuda Denshi (Japan)
2012-2024
Shibaura Institute of Technology
2023-2024
Futaba clinic
2013-2023
Jikei University School of Medicine
2020-2022
The University of Tokyo
2022
University of Oxford
2021
Saiseikaisenri Hospital
2020
Otsu Municipal Hospital
2019-2020
Kyushu Institute of Technology
2019
Hyperglycemia is a risk factor for sarcopenia when comparing individuals with and without diabetes. However, no studies have investigated whether the findings could be extrapolated to patients diabetes relatively higher glycemic levels. Here, we aimed clarify control was associated in type 2 diabetes.Study participants consisted of (n = 746, average age 69.9 years) an older general population 2,067, 68.2 years). Sarcopenia defined as weak grip strength or slow usual gait speed low skeletal...
Abstract Aims/Introduction It is unclear how changes in body composition induced by sodium–glucose cotransporter 2 ( SGLT 2) inhibitor treatment correlate with metabolic profile changes. We aimed to clarify component changes, and if causes sarcopenia bone mineral content BMC ) loss. Materials Methods Moderately obese Japanese type diabetes patients, treated luseogliflozin for a year, were observed prospectively evaluated analyzed the individual components during treatment, their correlation...
ObjectivesType 2 diabetes is a risk factor for sarcopenia. Evidence on the prevention of sarcopenia using blood glucose–lowering therapy limited. We aimed to examine relationship between changes in glycemic control and effect antidiabetic agents against patients with type diabetes.DesignWe conducted an observational longitudinal study.Setting ParticipantsIn total, 588 Japanese ongoing multicenter study completed 1-year follow-up measurements clinical data.MethodsThe data set Multicenter...
The significance of the minimal secretory capacity pancreatic beta-cells for stability plasma glucose level was studied in 20 patients with insulin-dependent diabetes mellitus. Changes concentrations major counterregulatory hormones response to hypoglycemia were also investigated these clarify their contribution diabetic brittleness. beta-Cell function evaluated on basis elevation C-peptide immunoreactivity (CPR) during intravenous glucagon test a highly sensitive assay CPR that could detect...
Aim We carried out a randomized controlled trial using ipragliflozin. analyzed changes in diastolic function echocardiography patients with type 2 diabetes and heart failure preserved ejection fraction. Methods an open‐label, multicenter, randomized, two‐arm interventional trial. A total of eligible 68 participants were randomly assigned into two groups (ipragliflozin group n = 36; conventional treatment 32). Primary end‐points the change E / e ' '. Secondary other parameters...
The Soft X-ray Imager (SXI) is the charge-coupled device (CCD) camera for soft imaging telescope Xtend installed on Imaging and Spectroscopy Mission (XRISM), which was adopted as a recovery mission Hitomi satellite successfully launched 2023 September 7 (JST). In order to maximize science output of XRISM, we set requirements find that CCD employed in Hitomi/SXI or similar, i.e., $2 \times 2$ array back-illuminated CCDs with $200~\mu$m-thick depletion layer, would be practically best among...
Abstract The Soft X-ray Imager (SXI) is the charge-coupled device (CCD) camera for soft imaging telescope Xtend installed on Imaging and Spectroscopy Mission (XRISM), which was adopted as a recovery mission Hitomi satellite successfully launched 2023 September 7 (JST). In order to maximize science output of XRISM, we set requirements found that CCD employed in Hitomi/SXI or similar, i.e., $2 \times 2$ array back-illuminated CCDs with $200\, \mu$m-thick depletion layer, would be practically...
Blood flow regulation in pancreatic islets is critical for function but poorly understood. Here, we establish an vivo imaging platform a non-human primate where transplanted autologously into the anterior chamber of eye are monitored non-invasively and longitudinally at single-cell resolution. Engrafted were vascularized innervated maintained cytoarchitecture situ pancreas. velocity engrafted was not affected by increasing blood glucose levels and/or GLP-1R agonist liraglutide. However,...
Though poor glycemic control and insulin treatment are reported to be associated with sarcopenia in type 2 diabetes, 1 diabetes may a stronger risk for sarcopenia. We therefore studied the effect of control, therapy on prevalence characteristics sarcopenia.A total 812 Japanese patients (type 1: n = 57; 2: 755) were enrolled this study. Sarcopenia was defined as low handgrip strength or slow gait speed appendicular skeletal muscle mass.Among participants aged ≥65 years, rate higher among...
XRISM (X-ray Imaging and Spectroscopy Mission) is an X-ray astronomy satellite developed in collaboration with JAXA, NASA ESA. It successfully launched on Sept. 7, 2023. Two complementary telescopes, Resolve Xtend are on-board XRISM. uses the pixelized micro calorimeter by NASA/GSFC has very high energy resolution of 5 eV. On other hand, CCD camera as its focal plane detector which spatial a wide field view. We evaluated performance Mirror Assembly (XMA) for using data observed during...
Abstract To localize the MHC-linked diabetogenic genes in nonobese diabetic (NOD) mouse, a recombinational hotspot from B10.A(R209) mouse was introduced to region between MHC class I K and II A of NOD with site centromeric Lmp2/Tap1 complex by breeding two strains. Replacement same R209 mice prevented development diabetes (from 71 3%) insulitis 61 15%) N7 intra-MHC recombinant mice. Similarly, replacement A, E D diseases (diabetes, 0%; insulitis, 3%). In addition genes, there are at least Lmp2.
Xtend is one of the two telescopes onboard X-ray imaging and spectroscopy mission (XRISM), which was launched on September 7th, 2023. comprises Soft Imager (SXI), an CCD camera, Mirror Assembly (XMA), a thin-foil-nested conically approximated Wolter-I optics. A large field view 38′ × over energy range from 0.4 to 13 keV realized by combination SXI XMA with focal length 5.6 m. The employs four P-channel, back-illuminated type CCDs thick depletion layer 200 μm. chips are arranged in 2×2 grid...
Summary Aim To clarify the association of several clinical parameters, including plasma fibrinogen level, with diabetic retinopathy in patients Type 2 diabetes mellitus (DM). Methods A total 294 Japanese DM were studied; 53 no (NDR), 90 background (BDR), and 151 proliferative (PDR). Multiple logistic regression analysis was performed to assess variables independently associated two settings: presence any severity advanced retinopathy. Results The following parameters identified as...
To investigate the efficacy and safety of sitagliptin in elderly patients with type 2 diabetes mellitus, a focus on hypoglycemia.Type mellitus who started therapy were followed for 52 weeks enrolled Impact Sitagliptin Diabetes Mellitus Japanese Elderly Patients study. The frequency hypoglycemia knowledge analyzed using questionnaire.In total, 5,130 (aged 73.8 ± 6.1 years) analyzed. A significant reduction glycated hemoglobin (-0.7 1.1%, P < 0.001) glycoalbumin levels (-2.2 3.8%, was observed...
Aging of skeletal muscle is characterized not only by a decrease quantity but also changes in quality, such as an increase stiffness. The present study aimed to investigate the effects supplementation with quercetin glycosides (QGs), well-known polyphenolic flavonoids, combined resistance exercise on and
The number of elderly type 2 diabetes mellitus (T2DM) patients in Japan is increasing continuously. Hypoglycemia a significant issue their treatment. However, the actual situation and related details hypoglycemia remain unclear. In order to elucidate them, Physicians Association conducted large-scale questionnaire survey for physicians outpatients all over Japan.Targeted T2DM were 65 years old or older 2011. Specialized forms distributed both patients. included questions whether patient had...
Evidence of a direct comparison between dipeptidyl-peptidase 4 inhibitors (DPP-4is) and sodium-glucose cotransporter 2 (SGLT2is) remains lacking, no clear treatment strategy or rationale has been established using these drugs. This study aimed to compare the overall efficacy safety DPP-4is SGLT2i luseogliflozin in patients with type diabetes mellitus (T2DM).Patients T2DM who had not used antidiabetic agents other than SGLT2is were enrolled after written informed consent obtained. The...