A5001935591- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Management and Research
- Immune Cell Function and Interaction
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Chronic Kidney Disease and Diabetes
- Adrenal and Paraganglionic Tumors
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Hormonal Regulation and Hypertension
- Pituitary Gland Disorders and Treatments
- Pancreatic and Hepatic Oncology Research
- Diet, Metabolism, and Disease
- Genetic Mapping and Diversity in Plants and Animals
- Diet and metabolism studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Peroxisome Proliferator-Activated Receptors
- Diabetes Management and Education
- Hair Growth and Disorders
- Neuroendocrine Tumor Research Advances
- Blood Pressure and Hypertension Studies
- Nutrition and Health in Aging
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
Kindai University
2016-2025
Osaka University
1999-2007
Bile acid–binding resins, such as cholestyramine and colestimide, have been clinically used cholesterol-lowering agents. These agents bind bile acids in the intestine reduce enterohepatic circulation of acids, leading to accelerated conversion cholesterol acids. A significant improvement glycemic control was reported patients with type 2 diabetes whose hyperlipidemia treated resins. To confirm effect drugs on glucose metabolism investigate underlying mechanisms, an animal model given a...
Programmed cell death-1 (PD-1) is a co-stimulatory molecule that inhibits T proliferation. We aimed to clarify PD-1 expression in CD4(+) cells and the association between 7785C/T polymorphism of PDCD1, with focus on two subtypes type 1 diabetes, 1A diabetes (T1AD) fulminant (FT1D), Japanese population. examined 22 patients T1AD, 15 FT1D, 19 2 (T2D) 29 healthy control (HC) subjects. Fluorescence-activated sorting (FACS) real-time PCR were utilized analyse quantitatively. Genotyping PDCD1 was...
The diagnostic criteria for slowly progressive type 1 diabetes (slowly insulin-dependent mellitus; SPIDDM) have been revised by the Committee on Type Diabetes of Japan Society. All following three must be met 'a definitive diagnosis SPIDDM': (1) presence anti-islet autoantibodies at some point in time during disease course; (2) absence ketosis or ketoacidosis with no requirement insulin treatment to correct hyperglycemia immediately after principle; and (3) gradual decrease secretion over...
Abstract Aims/Introduction Differences in the efficacy and safety of antidiabetic drugs among different ethnic groups are well documented. Metformin is widely used treatment type 2 diabetes Western countries, but high doses metformin have been approved only recently for clinical use Japan. The aim present study was to investigate effects dosage dosing frequency on high‐dose Japanese patients. Materials Methods A total 71 patients with were prospectively studied during hospitalization. Dose...
Objective Glomerular filtration rate (GFR) decreases without or prior to the development of albuminuria in many patients with diabetes. Therefore, and/or a low GFR diabetes is referred as diabetic kidney disease (DKD). A certain proportion show rapid progressive decline renal function unidirectional manner and are termed early decliners. This study aimed elucidate prevalence DKD decliners clarify their risk factors. Research design methods combination cross-sectional cohort included 2385...
BACKGROUND Mucosa-associated lymphoid tissue (MALT) lymphoma is a low-grade B-cell non-Hodgkin's lymphoma. Autoimmune (Hashimoto's) thyroiditis associated with thyroid MALT lymphoma, but co-existence papillary carcinoma (PTC) has been less commonly reported. In this case report, we describe 58-year-old man who presented 6-month history of hoarseness and an enlarged thyroid, was diagnosed Hashimoto's thyroiditis, PTC. CASE REPORT Upon referral to our hospital, he goiter hoarseness. Based on...
Abstract The targets for continuous glucose monitoring (CGM)-derived metrics were recently set; however, studies on CGM data over a long period with stable glycemic control are limited. We analyzed 194,279 values obtained from 19 adult Japanese patients type 1 diabetes. during four months analyzed. CGM-related of different durations “within 120, 90, 60, 30, and 7 days” calculated baseline. Time in range (TIR; 70–180 mg/dL), time above (TAR; ≥ 181 average levels, but not below (TBR; ≤ 69...
Though poor glycemic control and insulin treatment are reported to be associated with sarcopenia in type 2 diabetes, 1 diabetes may a stronger risk for sarcopenia. We therefore studied the effect of control, therapy on prevalence characteristics sarcopenia.A total 812 Japanese patients (type 1: n = 57; 2: 755) were enrolled this study. Sarcopenia was defined as low handgrip strength or slow gait speed appendicular skeletal muscle mass.Among participants aged ≥65 years, rate higher among...
Association studies are a potentially powerful approach to identifying susceptibility variants for common multifactorial diseases such as type 1 diabetes, but the results not always consistently reproducible. The IDDM5 locus has recently been narrowed an ∼200-kb interval on chromosome 6q25 by two independent groups. These demonstrated that alleles at markers in mitogen-activating protein kinase 7 interacting 2 (MAP3K7IP2)/SUMO4 region were associated with diabetes. Subsequent studies,...
Multiple autoimmune diseases, such as autoimmunity against the thyroid gland and pancreatic islets, are often observed in a single patient. Although alopecia areata (AA) is one of most frequent organ-specific association AA with other diseases genetic basis remain to be analyzed.The aim this study was clarify similarities differences HLA clinical characteristics islet patients AA.A total 126 were newly recruited. Anti-islet antithyroid autoantibodies tested, genotypes genes determined.Among...
Abstract Aims/Introduction Patients with a total pancreatectomy and type 1 diabetes are similar in regard to absolute insulin deficiency, but different glucagon, providing unique opportunity study the contribution of glucagon glucose metabolism an insulin‐dependent state. The aim present was investigate homeostasis complete deficiency vivo . Methods A 38 individuals lack endogenous (fasting C‐peptide <0.0066 nmol/L) whose glycemic control optimized pump during hospitalization were...
The Review of Diabetic Studies,2008,5,2,73-94.DOI:10.1900/RDS.2008.5.73Published:August 2008Type:Review Article Authors:Richard E Pratley, and Matthew Gilbert Author(s) affiliations:Richard E. Pratley Diabetes Metabolism Translational Medicine Unit, University Vermont College Medicine, Burlington, VT, USA. Abstract:Until recently, the pathogenesis type 2 diabetes mellitus (T2DM) has been conceptualized in terms predominant defects insulin secretion action. It is now recognized that...
OBJECTIVE Tissue-specific self-antigens are ectopically expressed within the thymus and play an important role in induction of central tolerance. Insulin is both pancreatic islets considered to be primary antigen for type 1 diabetes. Here, we report insulin transactivator MafA expression susceptibility RESEARCH DESIGN AND METHODS The profiles transcriptional factors (Pdx1, NeuroD, Mafa, Aire) were examined nonobese diabetic (NOD) control mice. Thymic Ins2 serum autoantibodies Mafa knockout...
Therapeutic blocking antibodies against programmed death 1 (PD1) and cytotoxic T-lymphocyte antigen 4 (CTLA4) are applied for advanced cancer therapy, but induce a wide range of immune-related adverse events. In our recent case 52-year-old female doctor suffering from breast having metastasized to the lung liver, it was decided use nivolumab prevent disease progressing after excisional surgeries multiple chemotherapies. One month completing course, fatigue, hypoglycemia hypotension developed...
Abstract Context Glucose tolerance worsens after distal pancreatectomy (DP); however, the long-term incidence and factors affecting interindividual variation in this worsening are unclear. Objective To investigate changes diabetes-related traits before DP to clarify of diabetes its predictors. Methods Among 493 registered patients, 117 underwent DP. these, 56 patients without surgery were included study. endocrine function prospectively assessed using a 75-g oral glucose test preoperatively,...