A5055859504- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Management and Research
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Diet, Metabolism, and Disease
- Birth, Development, and Health
- Diet and metabolism studies
- Gestational Diabetes Research and Management
- Adipose Tissue and Metabolism
- Adrenal Hormones and Disorders
- Immunodeficiency and Autoimmune Disorders
- Thyroid Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Digestive system and related health
- Growth Hormone and Insulin-like Growth Factors
- Inflammasome and immune disorders
- Pancreatitis Pathology and Treatment
- Protein Tyrosine Phosphatases
- Cell death mechanisms and regulation
- Monoclonal and Polyclonal Antibodies Research
- Trace Elements in Health
- Metabolism and Genetic Disorders
Koga Hospital
2015-2024
Université Paris-Saclay
2022-2023
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2022-2023
CEA LIST
2022-2023
Centre National de la Recherche Scientifique
2022
Université Grenoble Alpes
2022
Laboratoire de Physique et Modélisation des Milieux Condensés
2022
Kansai Rosai Hospital
2018
Nagasaki University Hospital
2007-2016
Nagasaki University
2001-2013
Islet cell antibodies (ICAs) are predictive of type I diabetes in first-degree relatives, but this immunohistochemical assay has proven difficult to standardize. As an alternative, we assessed the use radioassays for against three molecularly characterized islet autoantigens, including ICA512bdc (amino acid residues 256–979 IA-2 molecule, incorporating intracellular domain). We measured insulin autoantibodies (IAAs), GAD (GAAs), and (ICA512bdcAAs) by radioassay, addition ICAs, 882 relatives...
Abstract We have revised a part of the diagnostic criteria for fulminant type 1 diabetes. The new were set both to express essence this disease rapid increase patients' blood glucose and be highly sensitive reduce misdiagnosis. After analyzing data 382 patients with newly‐diagnosed diabetes, we adopted glycated hemoglobin (HbA 1c ) level 8.7% (National Glycohemoglobin Standardization Program [ NGSP ] value). criterion indicates 100% sensitivity best value by receiver operating characteristic...
OBJECTIVE— To describe the clinical and immunologic characteristics of fulminant type 1 diabetes, a novel subtype we conducted nationwide survey. RESEARCH DESIGN AND METHODS—History laboratory data, including islet-related autoantibodies, were examined in 222 patients with nonfulminant diabetes our hospitals addition to another 118 located outside Japan. RESULTS—In hospitals, studied, 43 (19.4%) diagnosed 137 (61.7%) classified as having autoimmune 42 diabetic subjects who not did have...
The goal of this study was to address whether antiislet autoantibodies appear sequentially or simultaneously before the onset type I diabetes. We analyzed sequential serum samples from 155 siblings and offspring (aged < 7 yr) patients with diabetes Denver Diabetes Autoimmunity Study in Young a separate group first degree relatives 2-40 for reacting three defined autoantigens: glutamic acid decarboxylase (GAD65), insulin, ICA512/IA-2. youngest age at which 1 3 appeared 1.1 yr, oldest 60.9 yr....
The protein tyrosine phosphatase, nonreceptor 22 gene (PTPN22) maps to human chromosome 1p13.3-p13.1 and encodes an important negative regulator of T-cell activation, lymphoid-specific phosphatase (Lyp). Recently, the minor allele a single-nucleotide polymorphism (SNP) at nucleotide position 1858 (rs2476601, +1858C > T) was found be associated with type 1 diabetes. However, degree association is variable among ethnic populations, suggesting presence other disease-associated variants in...
The Islet Autoantibody Standardization Program (IASP) aims to improve the performance of immunoassays measuring type 1 diabetes (T1D)-associated autoantibodies and concordance results among laboratories. IASP organizes international interlaboratory assay comparison studies in which blinded serum samples are distributed participating laboratories, followed by centralized collection analysis results, providing participants with an unbiased comparative assessment. In this report, we describe...
The diagnostic criteria for slowly progressive type 1 diabetes (slowly insulin-dependent mellitus; SPIDDM) have been revised by the Committee on Type Diabetes of Japan Society. All following three must be met 'a definitive diagnosis SPIDDM': (1) presence anti-islet autoantibodies at some point in time during disease course; (2) absence ketosis or ketoacidosis with no requirement insulin treatment to correct hyperglycemia immediately after principle; and (3) gradual decrease secretion over...
OBJECTIVE: The insulin-sensitizing action of troglitazone may be mediated through the activation peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and promotion preadipocyte differentiation in adipose tissue on which has depot-specific effects. We investigated relationship between efficacy drug body fat distribution. Changes distribution were also by long-term administration drug. RESEARCH DESIGN AND METHODS: Troglitazone was given at a dose 400 mg/day to 20 patients with type 2...
Autoantibodies to glutamic acid decarboxylase (GAD), previously reported be the 64,000-M(r) (64K) islet cell protein, were measured by a radioimmunoassay using purified pig brain GAD in 29 insulin-dependent diabetes mellitus (IDDM) patients with autoimmune thyroid disease (AITD) and sex- duration-matched IDDM without AITD. Islet antibodies (ICAs) 64K also determined. In short-duration (< 1 year), prevalence levels of 100% (8 8) 609 +/- 166 U (means SE), respectively, AITD 81.8% (9 11) 90 51...
Abstract Type 1 diabetes is a disease characterized by destruction of pancreatic β‐cells, which leads to absolute deficiency insulin secretion. Depending on the manner onset and progression, it classified as fulminant, acute‐onset or slowly progressive type diabetes. Here, we propose diagnostic criteria for mellitus. Among patients who develop ketosis diabetic ketoacidosis within 3 months after hyperglycemic symptoms require treatment continuously diagnosis diabetes, those with anti‐islet...
To characterize the clinical, autoimmune, and genetic features in Japanese adult-onset diabetic patients with GAD autoantibodies.GAD autoantibodies (GADab) were screened 4,980 age of onset >20 years hospital-based Ehime Study, GADab-positive (GADab(+)) then divided into two groups according to their insulin secretion compared nondiabetic subjects. The insulin-deficient state was defined as <0.33 nmol/l serum C-peptide (CPR) at 2 h postprandial or 6 min after a 1-mg glucagon load.GADab...
Restricted use of T cell receptor (TCR) gene segments is characteristic several induced autoimmune disease models. TCR sequences have previously been unavailable for pathogenic cells which react with a defined autoantigen in spontaneous disease. The majority clones, derived from islets NOD mice spontaneously develop type I diabetes, insulin peptide B-(9–23). We sequenced the α and β chains TCRs these B-(9–23)-reactive clones. No chain restriction was found. In contrast, clones (10 13) used...