A5103036805- Diabetes and associated disorders
- Pancreatic function and diabetes
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Diabetes Treatment and Management
- Bariatric Surgery and Outcomes
- Pluripotent Stem Cells Research
- Viral Infections and Immunology Research
- Growth Hormone and Insulin-like Growth Factors
- Adipose Tissue and Metabolism
- Thyroid Disorders and Treatments
- Eosinophilic Disorders and Syndromes
- Electrolyte and hormonal disorders
- Reproductive Biology and Fertility
- Peroxisome Proliferator-Activated Receptors
- interferon and immune responses
- Liver Disease and Transplantation
- Histiocytic Disorders and Treatments
- Potassium and Related Disorders
- Pharmacology and Obesity Treatment
- Digestive system and related health
Nagasaki University
1999-2024
St Vincents Institute of Medical Research
2017-2022
Nagasaki University Hospital
2012-2020
Koga Hospital
2013
Nagoya University
2002
University of California, Los Angeles
1993
Mitsubishi Group (Japan)
1993
OBJECTIVE: The insulin-sensitizing action of troglitazone may be mediated through the activation peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and promotion preadipocyte differentiation in adipose tissue on which has depot-specific effects. We investigated relationship between efficacy drug body fat distribution. Changes distribution were also by long-term administration drug. RESEARCH DESIGN AND METHODS: Troglitazone was given at a dose 400 mg/day to 20 patients with type 2...
Abstract Tyrosine kinase 2 (TYK2), a member of the JAK family, has attracted attention as potential therapeutic target for autoimmune diseases. However, role TYK2 in CD8 + T cells and type 1 diabetes (T1D) is poorly understood. In this study, we generate Tyk2 gene knockout non-obese (NOD) mice demonstrate that loss inhibits development autoreactive T-BET cytotoxic lymphocytes (CTLs) by impairing IL-12 signaling resident dendritic cell-driven cross-priming CTLs pancreatic lymph node (PLN)....
Hyperglycemia-induced embryonic malformations may be due to an increase in radical formation and depletion of intracellular glutathione (GSH) tissues. In the past, we have investigated role glutathione-dependent antioxidant system GSH on diabetes-related malformations. Embryos from streptozotocin-induced diabetic rats gestational day 11 showed a significantly higher frequency (neural lesions 21.5 vs. 2.8%, P<0.001; nonneural 47.4 6.4%, P<0.001) growth retardation than those normal mothers....
It has been reported that glucose responses during the oral tolerance test differ between healthy women and men. However, it remains unknown what factors contribute to these differences sexes. The present study analyzed insulin glucagon in 25 female 38 male young adults aged 22-30 years. plasma levels at 120 min were significantly higher than Insulin secretion was greater 30, 90 from baseline Glucagon suppression 30 men when determined by a sandwich enzyme-linked immunosorbent assay kit....
The diabetogenic effects of glucocorticoids appear to be dose dependent. To determine the different doses dexamethasone on glucose metabolism, we performed frequently sampled intravenous tolerance tests in 20 healthy young men. Glucose kinetics were analysed by minimal model. Ten subjects received low-dose (2 mg/day) for 3 days, and other 10 high-dose (6 days. rate disappearance (KG) did not decrease group (2.46 +/- 0.20 2.19 0.11% min-1, P = 0.35). In contrast, KG significantly (2.43 0.29...
Glycogenic hepatopathy (GH) has been reported as a very rare and under recognized complication in long-standing poorly controlled type 1 diabetes (T1D) patients. GH is characterized by transient elevation of liver transaminase hepatomegaly caused reversible excessive glycogen accumulation hepatocytes. It that indistinguishable from non-alcoholic fatty disease, which more commonly seen diabetic patients, even after history taken physical examination or imaging studies have performed. can only...
Cytokines that signal through the JAK-STAT pathway, such as interferon-γ (IFN-γ) and common γ chain cytokines, contribute to destruction of insulin-secreting β cells by CD8 + T in type 1 diabetes (T1D). We previously showed JAK1/JAK2 inhibitors reversed autoimmune insulitis non-obese diabetic (NOD) mice also blocked IFN-γ mediated MHC class I upregulation on cells. Blocking interferons their own does not prevent knockout NOD mice, so we tested whether JAK inhibitor action signaling...
We investigated the tissue-specific developmental expression and localization of GLUT-1 protein in rat embryo visceral yolk sac (VYS) during organogenic periods normal rats. The was then compared to that experimental diabetic rats test whether state would affect regulation glucose transporter early postimplantation (9.5-14.5 days), as we have previously demonstrated VYS down-regulated culture with hyperglycemic medium. In embryo, highly expressed stages organogenesis (between 9.5-12.5 days)...
The role of glucagon abnormality has recently been reported in type 2 diabetes; however, its gestational diabetes mellitus (GDM) is still unknown. glucose intolerance GDM heterogeneous, and not all patients require insulin treatment during pregnancy. Here, we investigated whether associated with the requirement for
Granzyme A is a protease implicated in the degradation of intracellular DNA. Nucleotide complexes are known triggers systemic autoimmunity, but role organ-specific autoimmune disease has not been demonstrated. To investigate whether such mechanism could be an endogenous trigger for we examined impact granzyme deficiency NOD mouse model diabetes. resulted increased incidence diabetes associated with accumulation ssDNA immune cells and induction interferon response pancreatic islets. Central...
Controlling postprandial glucose levels in patients with type 1 diabetes is challenging even under the adequate treatment of insulin injection. Recent studies showed that dysregulated glucagon secretion exacerbates hyperglycemia 2 patients, but little known patients. We investigated whether response to a meal ingestion could influence excursion diabetes.We enrolled 34 and 23 as controls. All underwent liquid mixed tolerance test. measured plasma glucose, C-peptide at fasting (0 min), 30, 60...
Granzyme B (GzmB) and perforin are proteins, secreted mainly by natural killer cells cytotoxic T lymphocytes that largely responsible for the induction of apoptosis in target cells. Because type 1 diabetes results from selective destruction β deficiency effectively reduces non-obese diabetic (NOD) mice, it can be deduced cell involves GzmB/perforin pathway. However, relevance GzmB remains totally unknown mice. In this study we have focused on examined consequence NOD We found NOD.GzmB(-/-)...