A5023836295- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Esophageal and GI Pathology
- Aluminum toxicity and tolerance in plants and animals
- Tracheal and airway disorders
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer Treatment and Pharmacology
- Plant Micronutrient Interactions and Effects
- Sphingolipid Metabolism and Signaling
- Obstructive Sleep Apnea Research
- Dermatological and Skeletal Disorders
- Airway Management and Intubation Techniques
- Immune Cell Function and Interaction
- Heterotopic Ossification and Related Conditions
- Colorectal Cancer Treatments and Studies
- Infectious Aortic and Vascular Conditions
- Breastfeeding Practices and Influences
- Vitamin K Research Studies
- Growth Hormone and Insulin-like Growth Factors
- Extraction and Separation Processes
- Bauxite Residue and Utilization
- Head and Neck Surgical Oncology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Plant Toxicity and Pharmacological Properties
City of Hope
2017-2025
City Of Hope National Medical Center
2021-2024
Tottori University
2024
Chiba University
1991-2022
Beckman Research Institute
2020
Creative Research Enterprises (United States)
2018
Chiba University Hospital
2018
University of Southern California
2017
The University of Kitakyushu
2015
Institute for Stem Cell Biology and Regenerative Medicine
2015
Significance A layer of fat surrounds the heart in most mammals, including humans. The biology this tissue has been speculated for centuries, but never subjected to experimental analysis because common model species are thought not have tissue. In study, we show that rodents cardiac fat, albeit a very specific location heart. We implicate origin from epicardium (the outer epithelium heart) and underlying mechanisms account its derivation. By comparing human mouse epicardial cells, provide an...
Advancing chimeric antigen receptor (CAR)-engineered adoptive T cells for the treatment of solid cancers is a major focus in field immunotherapy, given impressive recent clinical responses hematological malignancies. Prostate cancer may be amenable to cell-based immunotherapy since several tumor antigens, including prostate stem-cell (PSCA), are widely over-expressed metastatic disease. While selectivity CARs crucial, it problematic due absence truly restricted expression and potential...
Chimeric antigen receptor (CAR) T cell therapy has led to impressive clinical responses in patients with hematological malignancies; however, its effectiveness solid tumors been limited. While CAR cells for the treatment of advanced prostate and pancreas cancer, including those targeting stem (PSCA), are being clinically evaluated anticipated show bioactivity, their safety impact immunosuppressive tumor microenvironment (TME) have not faithfully explored preclinically. Using a novel human...
Background The immune suppressive tumor microenvironment (TME) that inhibits T cell infiltration, survival, and antitumor activity has posed a major challenge for developing effective immunotherapies solid tumors. Chimeric antigen receptor (CAR)-engineered therapy shown unprecedented clinical response in treating patients with hematological malignancies, intense investigation is underway to achieve similar responses Immunologically cold tumors, including prostate cancers, are often...
Abstract Chimeric antigen receptor (CAR) T cell therapeutic responses are hampered by limited trafficking, persistence, and durable anti-tumor activity in solid tumors. However, these challenges can be largely overcome relatively unconstrained synthetic engineering strategies. Here, we describe CAR cells targeting tumor-associated glycoprotein-72 (TAG72), utilizing the CD28 transmembrane domain upstream of 4-1BB co-stimulatory as a driver potent IFNγ secretion. cell-mediated production...
Hyperglycemia-induced embryonic malformations may be due to an increase in radical formation and depletion of intracellular glutathione (GSH) tissues. In the past, we have investigated role glutathione-dependent antioxidant system GSH on diabetes-related malformations. Embryos from streptozotocin-induced diabetic rats gestational day 11 showed a significantly higher frequency (neural lesions 21.5 vs. 2.8%, P<0.001; nonneural 47.4 6.4%, P<0.001) growth retardation than those normal mothers....
Loss-of-function mutations in ABCC6 can cause chronic or acute forms of dystrophic mineralization described disease models such as pseudoxanthoma elasticum (OMIM 26480) human and cardiac calcification mice. The protein is a large membrane-embedded organic anion transporter primarily found the plasma membrane hepatocytes. We have established complex experimental strategy to determine structural functional consequences disease-causing ABCC6. major aim our study was identify mutants with...
<title>Abstract</title> Background: Aging is the greatest risk factor for breast cancer, and although epithelial cells are source of carcinomas, changes alone do not fully explain cancer susceptibility. Fibroblasts macrophages key stromal constituents around origin in tissue. With age, surrounding terminal ductal lobular units (TDLUs) become increasingly immunosuppressive. CD105<sup>+</sup> fibroblasts intercalate within TDLUs, drive luminal differentiation, give rise to immunosuppressive...
Pseudoxanthoma elasticum (PXE) is a heritable disease characterized by calcified elastic fibers in cutaneous, ocular, and vascular tissues. PXE caused mutations ABCC6, which encodes protein of the ATP-driven organic anion transporter family. The inability this to secrete its substrate into circulation likely cause PXE. Vitamin K plays role regulation mineralization processes as co-factor carboxylation calcification inhibitors such Matrix Gla Protein (MGP). precursor or conjugated form has...
The synthesis of glucosylsphingosine (GlcSph), a glucosylceramide (GlcCer) analogue devoid fatty acids, in cultured fibroblasts was studied by using conduritol β epoxide (CBE), an inhibitor β-glucosidase, and l-phenyl-2-decanoylamino-3-morpholino-l-propanol (PDMP), synthase (glucosyltransferase). When CBE added to the culture medium, intracellular β-glucosidase activity decreased, both GlcCer GlcSph accumulated cells. After addition PDMP, concentration while content increased. PDMP were...
Abstract Aluminium (AI) enhances ferrous ion (Fe2+) -mediated lipid per oxidation which is the primary factor leading to cell death in nutrient medium tobacco cells. Under these conditions, processes were examined. Cells had been treated with AI and Fe2+ together exhibited shrinkage DNA ladders detected by agarose-gel electrophoresis form of bands corresponding increasing multiples ∼150 bp fragments. In calcium (Ca)-free medium, a combination Al enhanced only partly lipids hardly promoted...
The microflora in the periodontal pockets can affect dental pulp and cause endodontic-periodontal lesions or retrograde pulpitis. Here we report an lesion together with its bacterial profile. occurred maxillary right first molar of a 40-year-old woman who presented at our hospital complaining violent toothache since previous night. Clinically, tooth was caries-free electric test showed it to be vital. signs advanced periodontitis pocket deep, reaching apex palatal root. clinical diagnosis...
Advancing chimeric antigen receptor (CAR)-engineered T cells for the treatment of solid tumors is a major focus in field cellular immunotherapy. Several hurdles have hindered similar CAR cell clinical responses as seen hematological malignancies. These challenges include on-target off-tumor toxicities, which inspired efforts to optimize CARs improved tumor selectivity and overall safety. We recently developed therapy targeting prostate stem (PSCA) pancreatic cancers, showing preclinical...
Abstract Background: There is growing evidence that responsiveness to immunotherapy influenced by the composition of a patient’s gut microbiota. Recent analysis identified strong correlations between abundance microbial species and positive response immune based therapies in cancer patients. Further, enrichment commensal microbes can promote immunostimulatory effects, anti-tumor responses, increased cytotoxic T cell within TME. Conversely, presence known cause inflammatory states tissues may...
Journal Article Glucosylceramide and Glucosylsphingosine Metabolism in Cultured Fibroblasts Deficient Acid β-Glucosidase Activity Get access Naokazu Sasagasako, Sasagasako Department of Neurology, Neurological Institute, Faculty Medicine, Kyushu University, Higashi-ku, Fukuoka 812 Search for other works by this author on: Oxford Academic PubMed Google Scholar Takuro Kobayashi, Kobayashi 2 2To whom correspondence should be addressed. Yukiko Yamaguchi, Yamaguchi Nobue Shinnoh, Shinnoh Ikuo...
Abstract The aglycone stereochemistry of an intensely sweet saponin, polypodoside A isolated from the fern Polypodium glycyrrhiza, was revised 22S, 25R, 26S to 22R, 25S, 26R based on a direct chemical correlation with related osladin.
The role of endogenous glutathione (GSH) in the protection suspension‐cultured tobacco cells from aluminum (Al) toxicity was examined. Cells at logarithmic phase growth were treated with or without Al nutrient medium prepared P i and EDTA. In absence Al, total GSH content (including oxidized [GSSG]) increased gradually. presence increase repressed. This effect observed before loss plasma membrane integrity cell viability. contrast, GSSG Al. GSH‐deprived by culturing buthionine sulfoximine...
Delayed identification of infiltration and dysfunction peripheral intravenous (PIV) access can lead to serious consequences during general anesthesia in children. This preliminary study aimed describe the application precordial Doppler ultrasound children detect confirm correct PIV evaluate accuracy this method.This was a single-center, that conducted (<18 years) who were scheduled for elective surgeries between October 2019 March 2020. Rater anesthesiologists judged change sound (S test)...
AIMTo investigate that polysomnographic monitoring can accurately evaluate respiratory disturbance incidence during sedation for gastrointestinal endoscopy compare to pulse oximetry alone. METHODSThis prospective observational study included 10 elderly patients with early gastric cancer undergoing endoscopic submucosal dissection (ESD) under propofol sedation.Apart from routine cardiorespiratory monitoring, polysomnography measurements were acquired.The primary hypothesis was tested by...
Burosumab, a fully human monoclonal antibody against fibroblast growth factor 23, is mainly administered to patients with severe X-linked hypophosphatemia (XLH). However, there have been few reports on its use in relatively mild cases. In this report, we burosumab two siblings XLH who had effectively treated oral phosphate and active vitamin D. Both showed further improvement radiographic laboratory findings compared conventional treatment. Upon switching treatment, popliteal pain was...
フッ化ピリミジン系抗癌剤（以下5-FU）は体内でdihydoropyrimidine dehydrogenase（DPD）によって代謝され，DPD欠損や活性低下例では重篤な副作用を発症する．今回，CapeOX投与後に重篤な副作用を呈して死亡した症例を経験した．症例は58歳の男性．先天性小児麻痺を罹患，PS0．主訴は全身倦怠，食欲不振．現病歴はDay7までcapecitabineを内服後，摂食不良と脱水で入院．入院時Grade3口内炎と下痢，好中球減少を認めcapecitabine最終内服9日目から発熱性好中球減少症とGrade3口内炎を認めた．Nadir後状態改善し53日目に経口開始したが発熱，頻脈，意識レベル低下し，突然心停止となり死亡された．末梢血単核球DPD活性値は4.47U/mgと低値を示し，DPD活性低下症と診断された．5-FU投与時は副作用に注意し，本症例の早期発見に努める必要がある．