A5067626061- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Malaria Research and Control
- Mosquito-borne diseases and control
- Nanowire Synthesis and Applications
- Viral Infectious Diseases and Gene Expression in Insects
- Complement system in diseases
- Cancer Cells and Metastasis
- Virus-based gene therapy research
- Insect Pest Control Strategies
- Silicon Carbide Semiconductor Technologies
- Computational Drug Discovery Methods
- Cancer Immunotherapy and Biomarkers
- Zoonotic diseases and public health
- Drug-Induced Hepatotoxicity and Protection
- Mesenchymal stem cell research
- Insect Resistance and Genetics
- Hemoglobinopathies and Related Disorders
- Nerve injury and regeneration
- Vector-borne infectious diseases
- Electrospun Nanofibers in Biomedical Applications
- Nanofabrication and Lithography Techniques
University of California, Irvine
2021-2024
City of Hope
2017-2024
Purpose: Metastasis to the brain from breast cancer remains a significant clinical challenge, and may be targeted with CAR-based immunotherapy. CAR design optimization for solid tumors is crucial due absence of truly restricted antigen expression potential safety concerns "on-target off-tumor" activity. Here, we have optimized HER2-CAR T cells treatment metastases, determined optimal second-generation route administration xenograft mouse models metastatic tumors, including multifocal...
An effective combination immunotherapy using oncolytic viruses delivers de novo CD19 to promote CD19-CAR T cell therapy against solid tumors in mice.
Abstract Background Timely molecular surveillance of Plasmodium falciparum kelch 13 ( k13 ) gene mutations is essential for monitoring the emergence and stemming spread artemisinin resistance. Widespread resistance, as observed in Southeast Asia, would reverse significant gains that have been made against malaria burden Africa. The purpose this study was to assess prevalence polymorphisms western Kenya Ethiopia at sites representing varying transmission intensities between 2018 2022. Methods...
Advancing chimeric antigen receptor (CAR)-engineered adoptive T cells for the treatment of solid cancers is a major focus in field immunotherapy, given impressive recent clinical responses hematological malignancies. Prostate cancer may be amenable to cell-based immunotherapy since several tumor antigens, including prostate stem-cell (PSCA), are widely over-expressed metastatic disease. While selectivity CARs crucial, it problematic due absence truly restricted expression and potential...
Abstract Background Malaria remains a significant cause of morbidity and mortality in Ethiopia with an estimated 3.8 million cases 2021 61% the population living areas at risk malaria transmission. Throughout country Plasmodium vivax falciparum are co-endemic, Duffy expression is highly heterogeneous. The public health significance negativity relation to P. Ethiopia, however, unclear. This study seeks explore prevalence rates infection across phenotypes clinical community settings. Methods A...
Piperonyl butoxide (PBO)-synergized pyrethroid products are widely available for the control of pyrethroid-resistant mosquitoes. To date, no study has examined mosquito resistance after pre-exposure to PBO and subsequent enzymatic activity when exposed PBO-synergized insecticides. We used Culex quinquefasciatus Say (Diptera: Culicidae), an important vector arboviruses lymphatic filariasis, as a model examine insecticide mechanisms mosquitoes using modified World Health Organization tube...
Advancing chimeric antigen receptor (CAR)-engineered T cells for the treatment of solid tumors is a major focus in field cellular immunotherapy. Several hurdles have hindered similar CAR cell clinical responses as seen hematological malignancies. These challenges include on-target off-tumor toxicities, which inspired efforts to optimize CARs improved tumor selectivity and overall safety. We recently developed therapy targeting prostate stem (PSCA) pancreatic cancers, showing preclinical...
Irrigated agriculture enhances food security, but it potentially promotes mosquito-borne disease transmission and affects vector intervention effectiveness. This study was conducted in the irrigated nonirrigated areas of rural Homa Bay Kisumu Counties, Kenya.We performed cross-sectional longitudinal surveys to determine Plasmodium infection prevalence, clinical malaria incidence, molecular force (molFOI), multiplicity infection. We examined impact irrigation on effectiveness new...
Abstract Chimeric antigen receptor (CAR)-engineered T cell therapy for solid tumors is limited by the lack of tumor-restricted and homogeneous expression tumor antigens 1,2 . Therefore, we engineered an oncolytic virus to express a non-signaling, truncated CD19 (CD19t) protein tumor-selective delivery, enabling targeting CD19-specific CAR cells. Infecting cells with chimeric vaccinia coding CD19t (OV19t) produced de novo surface-antigen prior virus-mediated lysis. Co-cultured CD19-CAR...
As malaria control and elimination efforts ramp up in Ethiopia, more sensitive tools for assessing exposure to coendemic Plasmodium falciparum vivax are needed accurately characterize risk epidemiology. Serological markers have been increasingly explored as cost-effective measuring transmission intensity evaluating intervention effectiveness. The objectives of this study were evaluate the efficacy a panel 10 serological proxy determine underlying factors seropositivity. We conducted...
Abstract Background Malaria remains a significant cause of morbidity and mortality in Ethiopia with an estimated 4.2 million annual cases 61% the population living areas at risk malaria transmission. Throughout country Plasmodium vivax P. falciparum are co-endemic, Duffy expression is highly heterogeneous. The public health significance negativity relation to Ethiopia, however, unclear. Methods A total 9,580 4,667 subjects from community facilities endemic site epidemic-prone western were...
<p>Figure S1: HER2 expression in BBM1 tumors. (a) Representative histology of tumors engrafted mouse brain. N = normal brain, T tumor. Figure S2: Intraventricular HER2-BBζ CAR cell therapy is effective against S3: HER2+ BT474 tumors, but not HER2- MDA-MB-468 S4: CD4 and CD8 infiltrates tumors.</p>
<p>Figure S1: HER2 expression in BBM1 tumors. (a) Representative histology of tumors engrafted mouse brain. N = normal brain, T tumor. Figure S2: Intraventricular HER2-BBζ CAR cell therapy is effective against S3: HER2+ BT474 tumors, but not HER2- MDA-MB-468 S4: CD4 and CD8 infiltrates tumors.</p>
<div>Abstract<p><b>Purpose:</b> Metastasis to the brain from breast cancer remains a significant clinical challenge, and may be targeted with CAR-based immunotherapy. CAR design optimization for solid tumors is crucial due absence of truly restricted antigen expression potential safety concerns “on-target off-tumor” activity. Here, we have optimized HER2-CAR T cells treatment metastases, determined optimal second-generation route administration xenograft mouse models...
<div>Abstract<p><b>Purpose:</b> Metastasis to the brain from breast cancer remains a significant clinical challenge, and may be targeted with CAR-based immunotherapy. CAR design optimization for solid tumors is crucial due absence of truly restricted antigen expression potential safety concerns “on-target off-tumor” activity. Here, we have optimized HER2-CAR T cells treatment metastases, determined optimal second-generation route administration xenograft mouse models...
Abstract Advancing chimeric antigen receptor (CAR)-engineered adoptive T cells for the treatment of solid cancers is a major focus in field immunotherapy, given impressive recent clinical responses hematological malignancies. Prostate cancer should be amenable to CAR-based immunotherapy that several tumor antigens, including prostate stem-cell (PSCA), are widely over-expressed metastatic disease. The selectivity CARs crucial, however, due absence truly restricted expression and potential...
Abstract Piperonyl butoxide (PBO)-synergized pyrethroid products are widely available for the control of pyrethroid-resistant mosquitoes. To date, no study has formally examined mosquito resistance to PBO-synergized insecticides. We used Culex quinquefasciatus as a model insecticide mechanisms mosquitoes using modified World Health Organization tube bioassays and biochemical analysis metabolic enzyme expressions prior- post-PBO exposure. measured mortalities in with/without pre-exposure...