A5056746336- Mosquito-borne diseases and control
- Malaria Research and Control
- Insect Pest Control Strategies
- Dengue and Mosquito Control Research
- Viral Infections and Vectors
- Insect symbiosis and bacterial influences
- Studies on Chitinases and Chitosanases
- Insect Resistance and Genetics
- Extracellular vesicles in disease
- Parasitic infections in humans and animals
- Angiogenesis and VEGF in Cancer
- Species Distribution and Climate Change
- Parasites and Host Interactions
- Trauma and Emergency Care Studies
- Urban Transport and Accessibility
- Coronary Interventions and Diagnostics
- Insect and Arachnid Ecology and Behavior
- Circular RNAs in diseases
- Parasite Biology and Host Interactions
- Connexins and lens biology
- Zoonotic diseases and public health
- Traffic and Road Safety
- MicroRNA in disease regulation
Hainan Medical University
2018-2024
University of Hong Kong
2021-2024
Southern Medical University
2013-2023
University of California, Irvine
2020-2022
University of California System
2022
Taiyuan Central Hospital
2022
Aedes albopictus is a very invasive and aggressive insect vector that causes outbreaks of dengue fever, chikungunya disease, yellow fever in many countries. Vector ecology disease epidemiology are strongly affected by environmental changes. Urbanization worldwide trend one the most ecologically modifying phenomena. The purpose this study to determine how changes due urbanization affect albopictus.Aquatic habitats larval population surveys were conducted from May November 2013 three areas...
Background Aedes albopictus is an important dengue vector because of its aggressive biting behavior and rapid spread out native home range in Southeast Asia. Pyrethroids are widely used for adult mosquito control, resistance to pyrethroids should be carefully monitored control the only effective method currently available prevent transmission. The voltage-gated sodium channel gene target site pyrethroids, mutations this cause knockdown (kdr). Previous studies reported various (VGSC) gene,...
Aedes albopictus (Skuse) is an invasive mosquito that has become important vector of chikungunya, dengue and Zika viruses. In the absence specific antiviral therapy or a vaccine, management sole method available for reducing Aedes-induced disease morbidity. Determining resistance status Ae. to insecticides exploring mechanisms essential future control planning. larvae pupae were sampled from six sites (two each urban, suburban rural) in Guangzhou. The bioassays conducted against Bacillus...
The surveillance of vector mosquitoes is important for the control mosquito-borne diseases. To identify a suitable tool adult dengue Aedes albopictus, efficacy BG-Sentinel trap, CDC light trap and Mosquito-oviposition (MOT) on capture were comparatively evaluated in this study. efficiencies common tested laboratory setting, through release-recapture method, at two field sites Guangzhou, China from June 2013 to May 2014. captured counted, species identified compared among three traps basis...
Aedes albopictus is an important vector of Dengue virus (DENV) and it has quickly invaded the tropical temperate environments worldwide. A few studies have shown that, microRNAs (miRNAs) regulate mosquito defense against pathogens. However, there no systematic analysis impact DENV infection on miRNA expression in Ae. albopictus. We conducted this study to investigate upon DENV-2 using Illumina RNA sequencing.A total 103 known 5 novel candidate miRNAs were identified infected non-infected...
Emerging evidence indicates that microRNAs (miRNAs) are involved in host-virus interaction. We previously reported some miRNAs were differentially expressed sugar-fed and blood-fed females of Aedes albopictus (Ae. albopictus). Here, we analysis the role system an abundant midgut-specific miRNA mosquito Ae. albopictus. The expression profiles miR-281 different body parts following dengue virus infection determined using RT-qPCR Northern blot. mimics, antagomiRs corresponding negative controls...
Dengue is one of the most serious mosquito-borne infectious diseases in world. Aedes albopictus invasive mosquito and primary vectors dengue. Vector control using insecticides only viable strategy to prevent dengue virus transmission. In Guangzhou, after 2014 pandemic, massive have been implemented. Massive insecticide use may lead development resistance, but few reports are available on status resistance Guangzhou 2014. this study, Ae. were collected from four districts with varied...
Malaria is one of the most important public health problems in Southeast Asia, including Hainan Island, China. Vector control main malaria measure, and insecticide resistance a major concern for effectiveness chemical programs. The objective this study to determine status vector species pyrethroids other insecticides recommended by World Health Organization (WHO) indoor residual sprays. larvae pupae Anopheles mosquitoes were sampled from multiple sites five yielded sufficient susceptibility...
Abstract Background Temporal and stage specific expression of microRNAs (miRNAs) in embryos, larvae, pupae adults Aedes albopictus showed differential levels across the four developmental stages, indicating their potential regulatory roles mosquito development. The functional characterization these miRNAs was not known. Accordingly our study evaluated three miRNAs, which are temporally up-regulated various stages Ae. mosquitoes. Methods miRNA mimics, inhibitors negative controls were...
Abstract Background Mosquitoes are vectors of many tropical diseases. Understanding the ecology local mosquito vectors, such as species composition, distributions, population dynamics, and diversity is important for designing optimal strategy to control mosquito-borne Methods Entomological surveillance adult mosquitoes was conducted in five sites representing different ecological settings across Hainan Island from January December 2018 using BG Sentinel (BGS) traps Centers Disease Prevention...
Abstract BACKGROUND Aedes albopictus is a highly invasive mosquito and has become potential vector of dengue, chikungunya Zika viruses. Insecticide‐based interventions are the main tools for vector‐borne disease control. However, resistance to insecticides major threat effective prevention Five Ae. populations across Hainan Province, China were investigated susceptibility multiple insecticide mechanisms. RESULTS Larval bioassays indicated that pyrethroids was common in all larval...
Wide and improper application of pyrethroid insecticides for mosquito control has resulted in widespread resistance Aedes albopictus mosquitoes, an important dengue vector. Therefore, understanding the molecular regulation insecticide is urgently needed to provide a basis developing novel diagnostic methods vector approaches. We investigated transcriptional profiles deltamethrin-resistant -susceptible Ae. by performing paired-end sequencing RNA expression analysis. The analysis used 24...
Mosquitoes are vectors of many pathogens, such as malaria, dengue virus, yellow fever filaria and Japanese encephalitis virus. Wolbachia capable inducing a wide range reproductive abnormalities in their hosts, cytoplasmic incompatibility. has been proposed tool to modify mosquitoes that resistant pathogen infection an alternative vector control strategy. This study aimed determine natural infections different mosquito species across Hainan Province, China.
Environmental conditions affect the biology of mosquito vectors. Aedes albopictus is a major vector many important diseases including dengue, Zika, and chikungunya in China. Understanding development, fecundity, survivorship Ae. mosquitoes different environmental beneficial for implementation effective control measures.Aedes larval adult life-table experiments were conducted under natural indoor, half-shaded, fully shaded settings, simulating three habitat types Hainan Province, tropical...
Piperonyl butoxide (PBO)-synergized pyrethroid products are widely available for the control of pyrethroid-resistant mosquitoes. To date, no study has examined mosquito resistance after pre-exposure to PBO and subsequent enzymatic activity when exposed PBO-synergized insecticides. We used Culex quinquefasciatus Say (Diptera: Culicidae), an important vector arboviruses lymphatic filariasis, as a model examine insecticide mechanisms mosquitoes using modified World Health Organization tube...
Dengue is prevalent worldwide and transmitted by Aedes mosquitoes. Temperature a strong driver of dengue transmission. However, little known about the underlying mechanisms. albopictus mosquitoes exposed or not to virus serotype 2 (DENV-2) were reared at 23 °C, 28 °C 32 midguts residual tissues evaluated 7 days after infection. RNA sequencing midgut pools from control group, breakthrough group nonbreakthrough different temperatures was performed. The transcriptomic profiles analyzed using R...
Abstract An extensive network of storm water conveyance systems in urban areas, often referred to as the “underground drain system” (USDS), serves significant production habitats for mosquitoes. Knowledge whether USDS are suitable newly introduced dengue vectors Aedes aegypti and Ae. albopictus will help guide surveillance control efforts. To determine functions a larval habitat Culex , southern California, we examined mosquito utilization survivorship using laboratory microcosm studies. The...
The spatial accessibility of prehospital EMS is particularly important for the elderly population's physiological functions. Due to recent expansion aging populations all over globe, people's presents a serious challenge. An efficient strategy address this issue involves using geographic information systems (GIS)-based tools evaluate in conjunction with distribution people, available road networks, and facilities. This study employed gravity model empirical Bayesian Kriging (EBK)...
Abstract Background Aedes albopictus is an invasive vector of serious -borne diseases global concern. Habitat management remains a critical factor for establishing cost-effective systematic strategy sustainable control. However, the community-based characteristics Ae. habitats in complex urbanization ecosystems are still not well understood. Methods A large-scale investigation aquatic habitats, involving 12 sites selected as representative four land use categories at three levels, was...
Anopheles sinensis is a major malaria vector in Southeast Asia. Resistance to pyrethroid insecticides this species has impeded control the region. Previous studies found that An. populations from Yunnan Province, China were highly resistant deltamethrin and did not carry mutations voltage-gated sodium channel gene cause knockdown resistance. In study, we tested hypothesis other genomic variants are associated with resistance phenotype. Using paired-end whole genome sequencing (DNA-seq),...
Irrigated agriculture enhances food security, but it potentially promotes mosquito-borne disease transmission and affects vector intervention effectiveness. This study was conducted in the irrigated nonirrigated areas of rural Homa Bay Kisumu Counties, Kenya.We performed cross-sectional longitudinal surveys to determine Plasmodium infection prevalence, clinical malaria incidence, molecular force (molFOI), multiplicity infection. We examined impact irrigation on effectiveness new...
Aedes albopictus is an important vector for pathogens such as dengue, Zika, and chikungunya viruses. While insecticides the mainstay mosquito control, their widespread excessive use has led to increased resistance in Ae. globally. Gut symbiotic bacteria are believed play a potential role insect physiology, potentially linking mosquitoes' metabolic against insecticides. We investigated of development by comparing gut between deltamethrin-sensitive deltamethrin-resistant populations. Adults...
Emerging evidence indicates that microRNAs (miRNAs) are involved in host-virus interaction. We previously reported some miRNAs were differentially expressed sugar-fed and blood-fed females of Aedes albopictus (Ae. albopictus). Here, we analysis the role system an abundant midgut-specific miRNA mosquito Ae. albopictus. The expression profiles miR-281 different body parts following dengue virus infection determined using RT-qPCR Northern blot. mimics, antagomiRs corresponding negative controls...