A5082779596- Hippo pathway signaling and YAP/TAZ
- Birth, Development, and Health
- Digital Holography and Microscopy
- Gestational Diabetes Research and Management
- Advanced X-ray Imaging Techniques
- Acute Myeloid Leukemia Research
- Autophagy in Disease and Therapy
- Land Use and Ecosystem Services
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Pregnancy and preeclampsia studies
- Remote Sensing in Agriculture
- Cancer-related gene regulation
- Fatty Acid Research and Health
- Drug Transport and Resistance Mechanisms
- Meningioma and schwannoma management
- Histone Deacetylase Inhibitors Research
- Receptor Mechanisms and Signaling
- Advanced Electron Microscopy Techniques and Applications
- Nicotinic Acetylcholine Receptors Study
- Colorectal Cancer Surgical Treatments
- Ocular Oncology and Treatments
- Clinical practice guidelines implementation
- Hypothalamic control of reproductive hormones
- Neuroinflammation and Neurodegeneration Mechanisms
Zhengzhou University
2024-2025
Xi'an Institute of Optics and Precision Mechanics
2021-2025
State Key Laboratory of Transient Optics and Photonics
2025
Shandong University of Finance and Economics
2025
Shanxi University
2019-2024
Fujian Medical University
2024
Hebei University of Chinese Medicine
2022-2024
Xinjiang Institute of Ecology and Geography
2021-2024
Chinese Academy of Sciences
2021-2024
East China Normal University
2024
Arid areas cover approximately 41% of Earth's land surface and support more than 38% the global population. As an important part drylands, oases are main carriers human production, socioeconomic activity, ecological environment. Oases typically sustain nearly all arid region's population produce 95% its gross domestic product. The ongoing intensification warming activities has resulted in water stress water-related environmental problems areas, along with degradation desertification. risk...
Pyridine derivatives are valuable components of biologically active compounds, materials, and ligands; however, traditional methods for site-selective direct functionalization often hindered by multistep procedures harsh conditions. Herein, we report a streamlined approach the selective C4-alkylation pyridine under electroreductive conditions using alkyl bromides. The addition chlorotrimethylsilane significantly enhanced yield regioselectivity, mechanistic studies revealed that reaction...
Early diagnosis of knee meniscus tears is important for timely intervention, reduced recovery time, and avoidance chronic problems. However, MRI-based medical imaging the best method to visualize multiple planes identify such tears. Based on this, machine learning artificial intelligence methods have recently gained enormous traction tear detection using MR images. This study presents a new methodology involving deep metaheuristic optimization accurate automated Our approach consists...
Background: Post-operative delirium (POD) is a common and serious clinical condition that occurs following anesthesia/surgery. While its impact well recognized, the underlying electrophysiological mechanisms remain largely unknown, posing challenges for effective treatment. This study aims to investigate hippocampal neural dynamics before after anesthesia/surgery in aged mice, which have tendency of developing POD. Methods: included adult mice with POD model. POD-like behavior was assessed N...
Background Primary central nervous system lymphoma (PCNSL) is a highly aggressive and rare extranodal non-Hodgkin (NHL). The MSKCC the IELSG scores represent most widely used prognostic models, but many changes have occurred in therapeutic protocols since their development. Moreover, PCNSL patients cannot be classified using score. We thus aimed to create novel, effective feasible model for PCNSL. Methods included 248 diagnosed with Our primary endpoint was overall survival (OS) we receiver...
Loss of FXR, one bile acid receptors, enlarged livers. Yes-associated protein 1 (YAP1), a dominant oncogene, promotes hepatocellular carcinoma (HCC). However, the relationship between FXR and YAP1 was unspecified in homeostasis HCC. Here, we used TIMER2.0, Cancer Genome Atlas (TCGA) Database, Kaplan–Meier Plotter Database discovered that positively correlated with better prognosis liver cancer patients. Our previous research showed dihydroartemisinin (DHA) inhibited cell proliferation HepG2...
Abstract Aims Previous studies have found that a single liver enzyme may predict gestational diabetes mellitus (GDM), but the results been inconsistent. This study aimed to explore associations of enzymes in early pregnancy with risk GDM, as well independently rank factors. Methods prospective cohort included 1295 women who underwent measurements during and completed GDM assessment mid‐pregnancy. Logistic regression restricted cubic spline analyses were conducted assess relationship between...
Blood urea nitrogen (BUN) is a surrogate marker for neurohormonal activation, but the association between BUN and post-discharge prognosis in elderly patients with acute decompensated heart failure (ADHF) not well defined. We explored all-cause mortality 652 (73.9 ± 7.8 yr) ADHF. All were followed mean duration of 32 months (12-69 months). was analyzed both as continuous variable according to two categories: low group (BUN < 15.35 mmol/L, N = 361) high ≥ 291). The risk increased by 1.6% per...
To investigate the effect of sarcopenia on prognosis stage II-III colorectal cancer patients undergoing adjuvant chemotherapy.A total 196 who received 8 cycles postoperative chemotherapy were retrospectively analyzed. An abdominal CT acquired at 3-4 weeks after surgery was used to calculate psoas muscle index. Subsequently, once gender-specific receiver operating characteristic curves plotted and cut-off values index defined, clinicopathological characteristics with high low compared....
Rosmarinic acid, a common ester extracted from Rosemary, Perilla frutescens, and Salvia miltiorrhiza Bunge, has been shown to have protective effects against various diseases. This is an investigation into whether rosmarinic acid can also affect the changes of white matter fibers cognitive deficits caused by hypoxic injury. The right carotid artery 3-day-old rats was ligated for 2 hours. were then prewarmed in plastic container with holes lid, which placed 37°C water bath 30 minutes....
The O(6)-methylguanine-DNA methyltransferase (MGMT) gene is a tumor suppressor that associated with the risk of developing acute myeloid leukemia (AML). However, association between methylation status MGMT promoter and chemotherapeutic outcomes patients AML remains unknown. In present study, 30 bone marrow samples derived from were collected prior subsequent to chemotherapy. in specimens was determined by methylation-specific polymerase chain reaction. results indicated influenced different...
As a common and disabling disease of the elderly, standard therapies Parkinson's (PD) fail to curb ongoing neurodegeneration, thus calling for newer strategies. This work was conducted examine effect microRNA-381 (miR-381) on oxidative stress injury dopaminergic neurons in PD vivo vitro. We established an mouse model using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) vitro cell by treating neuron MN9D cells with 1-methyl-4-phenylpyridinium (MPP+). It that miR-381 poorly expressed...
In this study, a robust adaptive filter using fuzzy logic for tightly‐coupled visual‐inertial odometry (VIO) navigation system is proposed. First, the authors use epipolar geometry and trifocal tensor as measurement models of VIO system, which can avoid calculating three‐dimensional position feature points. Second, camera poses corresponding to three images are corrected in form multi‐state constraint Kalman filter. Finally, when noise statistics changes or erroneous occurs practical...