A5060802281- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Catalytic Cross-Coupling Reactions
- Supramolecular Chemistry and Complexes
- Asymmetric Hydrogenation and Catalysis
- Synthesis and Catalytic Reactions
- Luminescence and Fluorescent Materials
- Molecular Sensors and Ion Detection
- Sulfur-Based Synthesis Techniques
- Supramolecular Self-Assembly in Materials
- Organometallic Complex Synthesis and Catalysis
- Chemical Synthesis and Analysis
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Cyclopropane Reaction Mechanisms
- Oxidative Organic Chemistry Reactions
- Crystallography and molecular interactions
- Ferrocene Chemistry and Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Chemical Synthesis and Reactions
- Radical Photochemical Reactions
- Synthetic Organic Chemistry Methods
- Fluorine in Organic Chemistry
- Organic Light-Emitting Diodes Research
- Asymmetric Synthesis and Catalysis
Zhengzhou University
2016-2025
First Affiliated Hospital of Zhengzhou University
2022
Guangzhou University
2020
State Council of the People's Republic of China
2015-2019
Luoyang Normal University
2010-2016
Fudan University
2014
Zhengzhou University of Light Industry
2011
Xiamen University
2011
Henan University
2010
Abstract The cobalt‐catalyzed alkoxylation of C(sp 2 )H bonds in aromatic and olefinic carboxamides has been developed. reaction proceeded under mild conditions the presence Co(OAc) ⋅4H O as catalyst tolerates a wide range both alcohols benzamide substrates, including even carboxamides. In addition, this is first example direct alkenes through CH bond activation.
Aryl-based pincer metal complexes with anionic terdentate ligands have been widely applied in organic synthesis, organometallic catalysis and other related areas. Synthetically, the most simple convenient method for construction of these is direct metal-induced Caryl–H bond activation, which can be fulfilled by choosing appropriate functional donor groups two side arms aryl-based preligands. In this perspective, we wish to summarize some results achieved our group context. Successful...
A highly efficient cobalt(II)-catalyzed alkynylation/annulation of terminal alkynes assisted by an N,O-bidentate directing group is described. This protocol characterized wide substrate scope utilizing cheap cobalt catalysts, and offers a new approach to 3-methyleneisoindolin-1-one, which can be converted into oxadiazine salt in one step. Moreover, the could removed three steps.
The visible-light-mediated oxydifluoromethylation of olefinic amides with difluoromethyl sulfones has been explored. This method allows for an efficient and practical synthesis a variety CF2H-containing benzoxazines oxazolines bearing various functional groups under mild conditions.
Abstract Coordination-driven self-assembly has emerged as a powerful bottom-up approach to construct various supramolecular architectures with increasing complexity and functionality. Tetraphenylethylene (TPE) been incorporated into metallo-supramolecules build luminescent materials based on aggregation-induced emission. We herein report three generations of ligands full conjugation TPE 2,2′:6′,2″-terpyridine (TPY) emissive materials. Due the bulky size TPY substituents, intramolecular...
A new cobalt(II)-catalyzed decarboxylative C–H activation/annulation of benzamides and alkynyl carboxylic acids has been described. Alkynyl were first employed as the coupling partners using inexpensive Co(OAc)2·4H2O catalyst. This method enables a switchable cyclization to isoquinolones isoindolinones with excellent selectivity. Moreover, catalytic amount Ag2O was adopted co-catalyst O2 (from air) terminal oxidant for preparation isoquinolones.
Novel iodine-induced sulfonylation and sulfenylation of imidazopyridines have been described using sodium sulfinates as the sulfur source. This strategy enables highly selective difunctionalization imidazo[1,2-a]pyridine to access sulfones sulfides in good yields. A wide range substrates functional groups were well-tolerated under optimized conditions. Moreover, control experiments conducted, indicating a radical pathway involved reaction mechanisms.
In this study, we overcame a challenge in conventional self-assembly of macrocycles that uses ditopic 2,2':6',2″-terpyridine (tpy) building blocks with 120° angle between two ligating moieties, which generally produces mixture multiple instead single hexagon. Two supramolecular hexagon wreaths, [Zn9LA6] and [Zn12LB6], were designed self-assembled from tritopic tetratopic tpy ligands Zn(II) ions, respectively. These multitopic ligands, bearing binding sites, increased the total density...
A new method of cobalt-catalyzed amination arylamides with simple alkylamines is reported through C(sp2)–H bond functionalization. For the first time, inexpensive cobalt exploited as catalyst in using alkylamines.
Using a series of tritopic 2,2':6',2″-terpyridine (tpy) ligands constructed on adamantane, three discrete 3D metallo-supramolecular architectures were assembled, i.e., trigonal bipyramidal, tetrahedron, and cube. The self-assembly used as corner directing units metal ions glue at the edge. angles linkers between adamantane tpy head play critical role in guiding assembled structures, which have general formula M3nL2n, where M denotes ion L ligand. All complexes fully characterized by (1)H,...
Copper-mediated selective mono- or diaryloxylation of benzamides has been achieved by using 2-aminopyridine 1-oxide as a new and removable N,O-bidentate directing group. The reaction system shows broad substrate scope provides straightforward way for the synthesis diaryloxylated benzoic acids.
Abstract Nested concentric structures widely exist in nature and designed systems with circles, polygons, polyhedra, spheres sharing the same center or axis. It still remains challenging to construct discrete nested architecture at (supra)molecular level. Herein, three generations ( G2 − G4 ) of giant supramolecules, Kandinsky have been assembled molecular weight 17,964, 27,713 38,352 Da, respectively. In ligand preparation, consecutive condensation between precursors primary amines pyrylium...
A visible-light-induced C-3 selective trifluoroethylation of imidazoheterocycles using 1,1,1-trifluoro-2-iodoethane as trifluoroethyl radical sources was developed. The methodology enables the introduction a group in fast and efficient reaction under mild conditions with excellent regioselectivities high functional tolerance.
A series of novel ruthenium(II) complexes supported by a symmetrical NNN ligand were prepared and fully characterized. These exhibited good performance in transfer hydrogenation to form new C–C bonds using alcohols as the alkylating agents, generating water only byproduct. broad range substrates, including (hetero)aryl- or alkyl-ketones alcohols, well tolerated under optimized conditions. Notably, α-substituted methylene ketones also investigated, which afforded α-branched steric hindrance...
A nickel(II)-catalyzed alkynylation/annulation cascade via double C–H cleavage has been successfully achieved. This methodology adopted a removable N,O-bidentate directing group with broad range of amide substrates and terminal alkynes being well tolerated. The catalytic system allowed for atom-economical environmentally benign one-pot construction the corresponding 3-methyleneisoindolin-1-one derivatives using O2 as external oxidant.
Three dimensional (3D) supramolecules with giant cavities are attractive due to their wide range of applications. Herein, we used pentatopic terpyridine ligands three types coordination moieties assemble two supramolecular hexagonal prisms a molecular weight up 42 608 and 43 569 Da, respectively. Within the prisms, double-rimmed Kandinsky Circles serve as base surfaces well templates for assisting self-sorting during self-assembly. Additionally, hierarchical self-assembly these into...
In an effort to exert more precise control over structural features of supramolecules, a series giant concentric hexagons were assembled as discrete structures using tetratopic terpyridine (tpy) ligands. preparation ligand, pyrylium and pyridinium salts chemistry significantly facilitated synthesis. The key compounds obtained by condensation reactions with corresponding primary amine derivatives in good yields. These metallo-supramolecular fully characterized NMR, ESI–MS, TWIM–MS, TEM,...
A series of chiral PCN pincer Pd(II) complexes VI–XIII with aryl-based aminophosphine–imidazoline or phosphinite–imidazoline ligands were synthesized and characterized. They examined as enantioselective catalysts for the hydrophosphination enones. Among them, complex IX, which features a Ph2PO donor well an imidazoline (4S)-phenyl N-Tol-p groups, was found to be optimal catalyst. Thus, in presence 2–5 mol % IX wide variety enones reacted smoothly diarylphosphines give corresponding phosphine...
A copper-mediated direct C3 amination of imidazopyridines has been disclosed under additive-free conditions in short reaction times. This methodology utilizes commercially available N-fluorobenzenesulfonimide (NFSI) as the amino source, which exhibits broad substrate scope and good functional group tolerance. The obtained C3-aminated can undergo further desulfonylation transformations. Control experiments suggest that this probably proceeds via a free-radical mechanism. Moreover, NFSI also...
A sustainable and transition metal-free approach for C3 chalcogenation chalcogenocyanation of imidazopyridines with KXCN (X = S or Se) has been developed under mild conditions. Importantly, this reaction was performed in the presence catalytic iodine aqueous medium, which afforded either chalcogenated chalcogenocyanated temperature control. The current protocol featured a broad substrate scope, organic solvent-free conditions, operational convenience, gram-scale production.
Six unsymmetrical chiral PCN pincer Pd(II) complexes 3a−f based on (imidazolinyl)aryl phosphinite ligands were easily synthesized from imidazolinyl-containing m-phenol derivatives 2a−e by one-pot phosphorylation/palladation reaction via C−H bond activation of the related ligands. An Ni(II) complex, 4a, was first obtained in a similar way. The palladium−chloride complex 3e could be readily converted to corresponding iodide derivative 5e halide exchange with KI. All eight characterized X-ray...
The synthesis and characterization of a series platinum(II) palladium(II) pincer complexes with chiral NCN ligands based on 1,3-bis(2′-imidazolinyl)benzene are reported. new ligand precursors 3a−m were easily prepared from inexpensive, readily available isophthalyl chloride or 5-substituted amino alcohols in two steps. Direct C2 metalation 3 K2PtCl4 provided convenient access to the corresponding platinum 4 51−84% isolated yields. On basis same methodology, seven palladium 5 synthesized...