A5018110254- Lipid Membrane Structure and Behavior
- Surfactants and Colloidal Systems
- Supramolecular Self-Assembly in Materials
- Spectroscopy and Quantum Chemical Studies
- Protein Structure and Dynamics
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Luminescence and Fluorescent Materials
- X-ray Diffraction in Crystallography
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanopore and Nanochannel Transport Studies
- Crystallization and Solubility Studies
- Advanced biosensing and bioanalysis techniques
- Molecular Sensors and Ion Detection
- Sphingolipid Metabolism and Signaling
- Nuclear Physics and Applications
- Hydrogels: synthesis, properties, applications
- Force Microscopy Techniques and Applications
- Polydiacetylene-based materials and applications
- Advanced Polymer Synthesis and Characterization
- Polymer Surface Interaction Studies
- Polymer Nanocomposites and Properties
- Pickering emulsions and particle stabilization
- Electrostatics and Colloid Interactions
- Machine Learning in Materials Science
University of Connecticut
2016-2025
Material Sciences (United States)
2011-2021
London Rebuilding Society
2017-2019
Oak Ridge National Laboratory
2019
Instituto de Ciencia de Materiales de Sevilla
2018
Canadian Nuclear Laboratories
2004-2011
Steacie Institute for Molecular Sciences
2003-2010
Western University
2007-2010
National Research Council Canada
2004-2010
National Institute of Standards and Technology
2001-2010
Nanocoatings with exceptional mechanical, barrier, and flame-retardant properties were fabricated via one-step coassembly.
Combinatory modulation of the physical and biochemical characteristics nanocarrier delivery systems is an emergent topic in field nanomedicine. Here, we studied combined effects incorporation active targeting moieties into nanocarriers their morphology affecting enhanced permeation retention effect for nanomedicine cancer therapy. Self-assembled lipid discoidal vesicular nanoparticles with low-polydispersity sub-50 nm size range identical chemical compositions were synthesized,...
Using neutron diffraction Harroun et al. [(2006) Biochemistry 45, 1227-1233; (2008) 47, 7090-7096] carried out studies that unequivocally demonstrated cholesterol preferentially sequestering in the middle of bilayers (i.e., flat orientation) made lipids with polyunsaturated fatty acids (PUFA), contrast to its "usual" position where hydroxyl group locates near lipid/water interface upright orientation). Here we clearly show, using diffraction, cholesterol's orientational preference different...
Three dimensional (3D) supramolecules with giant cavities are attractive due to their wide range of applications. Herein, we used pentatopic terpyridine ligands three types coordination moieties assemble two supramolecular hexagonal prisms a molecular weight up 42 608 and 43 569 Da, respectively. Within the prisms, double-rimmed Kandinsky Circles serve as base surfaces well templates for assisting self-sorting during self-assembly. Additionally, hierarchical self-assembly these into...
Control of interparticle interactions in terms their direction and strength highly relies on the use anisotropic ligand grafting nanoparticle (NP) building blocks. We report a deficiency exchange strategy to achieve site-specific polymer gold nanorods (AuNRs). Patchy AuNRs with controllable surface coverage can be obtained during hydrophobic polystyrene an amphiphilic surfactant while adjusting concentration (CPS) solvent condition (Cwater dimethylformamide). At low density ≤0.08 chains/nm2,...
The structural phases of magnetically alignable lipid mixtures were investigated as a function temperature and concentration using small-angle neutron scattering (SANS). Two systems examined: (a) an aqueous mixture DMPC (dimyristoyl phosphatidylcholine) DHPC (dihexanoyl lipids doped with Tm3+ ions resulting in the positive alignment system applied magnetic field (b) above containing negatively charged lipid, DMPG (dimyristoylphosphatidylglycerol). For both systems, three different patterns...
Mixtures of long- and short-chain phospholipids, specifically 14:0 6:0 phosphatidylcholines (DMPC DHPC), have been used successfully in NMR studies as magnetically alignable substrates for membrane-associated proteins. However, recent publications shown that the phase behavior these mixtures is much more complex than originally thought. Using polarized light microscopy small-angle neutron scattering, diagrams DMPC/DHPC at molar ratios 2, 3.2, 5 determined. Generally, temperatures below...
Poly(vinyl alcohol) (PVA) hydrogels are formed by physical cross-linking through freeze/thaw cycles. By controlling the stress applied during process, anisotropic PVA can be produced. An hydrogel conduit that mimics nonlinear and mechanical properties displayed porcine aorta was developed. Preliminary structural characterization of isotropic samples using small-angle neutron scattering reveals a polymer mesh cross-linked crystallites spaced about 18 nm and, most importantly, due to...
The asymmetric outer membrane of Gram-negative bacteria contains lipopolysaccharides (LPSs) which contribute significantly to the bacterium's surface properties and play a crucial role in regulating permeability. We report on neutron diffraction studies performed aligned, self-assembled bilayers Na-, Ca-, Mg-salt forms LPS isolated from Pseudomonas aeruginosa PAO1. From one-dimensional scattering length density profiles we find that water penetrates Ca2+-LPS lesser extent than either Na+- or...
The thermoresponsive PEG-based copolymer poly[2-(2-methoxyethoxy)ethyl methacrylate-co-oligo(ethylene glycol) methacrylate) (P(MEO2MA-co-OEGMA)] was grafted onto a silicon wafer, and its chain conformation in aqueous solution studied by neutron reflectometry. effects of temperature salt concentration on the polymer's were evaluated. With increasing temperature, it found that polymer brushes underwent transition from an extended state to compressed state, eventually collapsed above lower...
A three-dimensional nanoporous polystyrene/pyrene film was fabricated by dip-coating process onto a glass slide. Its fluorescence is rapidly and selectively quenched nitroaromatic vapors.
Abstract Synthetic polypeptides have received increasing attention due to their ability form higher ordered structures similar proteins. The control over secondary structures, which enables dynamic conformational changes, is primarily accomplished by tuning the side-chain hydrophobic or ionic interactions. Herein we report a strategy modulate conformation of utilizing donor–acceptor interactions emanating from H-bonding ligands. Specifically, 1,2,3-triazole groups, when incorporated onto...
Many diseases, especially cancer, are caused by the abnormal expression of non-coding microRNAs (miRNAs), which regulate gene expression, leading to development miRNA-based therapeutics. Synthetic miRNA inhibitors have shown promising efficacy in blocking activity aberrant miRNAs that upregulated disease-specific pathologies. On other hand, aid preventing certain diseases and reduced disease state need different strategies. To tackle this, mimics, mimic endogenous miRNAs, can be delivered...