A5048030408- Bacterial biofilms and quorum sensing
- Zeolite Catalysis and Synthesis
- Mesoporous Materials and Catalysis
- Bacteriophages and microbial interactions
- Bacterial Genetics and Biotechnology
- Vitamin D Research Studies
- Vibrio bacteria research studies
- Antimicrobial Resistance in Staphylococcus
- Catalytic Processes in Materials Science
- Medical and Biological Ozone Research
- Analytical Chemistry and Chromatography
- Antibiotic Resistance in Bacteria
- Digestive system and related health
- Metal-Organic Frameworks: Synthesis and Applications
- Crystallization and Solubility Studies
- Advanced Chemical Physics Studies
- Molecular spectroscopy and chirality
- Catalysis and Oxidation Reactions
- Nutrition, Genetics, and Disease
- Waste Management and Environmental Impact
- Luminescence and Fluorescent Materials
- Thermodynamic properties of mixtures
- Magnesium in Health and Disease
- Cell Image Analysis Techniques
- X-ray Diffraction in Crystallography
University of South Florida
2018-2023
University of Montana
2021-2023
Łukasiewicz Research Network - Industrial Chemistry Institute
2005-2016
Instytut Chemii i Techniki Jądrowej
2016
ITRI International
2009
In-Q-Tel
2008
Aggregation-induced emission (AIE) was intensively studied because of packing small molecules and polymers; however, mid-molecular-weight (1000–3000) molecular scaffold containing a precise number AIE luminogens is rare. Herein, we report the investigation three tetraphenylethylene (TPE)-modified sulfono-γ-AApeptides in which multiple TPE moieties are conjugated to chiral right-handed helical peptidomimetic backbone as functional side chains. The crystal structure TPE-α/sulfono-γ-AA peptide...
Abstract Nested concentric structures widely exist in nature and designed systems with circles, polygons, polyhedra, spheres sharing the same center or axis. It still remains challenging to construct discrete nested architecture at (supra)molecular level. Herein, three generations ( G2 − G4 ) of giant supramolecules, Kandinsky have been assembled molecular weight 17,964, 27,713 38,352 Da, respectively. In ligand preparation, consecutive condensation between precursors primary amines pyrylium...
Three dimensional (3D) supramolecules with giant cavities are attractive due to their wide range of applications. Herein, we used pentatopic terpyridine ligands three types coordination moieties assemble two supramolecular hexagonal prisms a molecular weight up 42 608 and 43 569 Da, respectively. Within the prisms, double-rimmed Kandinsky Circles serve as base surfaces well templates for assisting self-sorting during self-assembly. Additionally, hierarchical self-assembly these into...
Binary fission has been well studied in rod-shaped bacteria, but the mechanisms underlying cell division spherical bacteria are poorly understood. Rod-shaped harbor regulatory proteins that place and remodel machinery during cytokinesis. In human pathogen Staphylococcus aureus, we found essential protein GpsB localizes to mid-cell co-constricts with machinery. Depletion of arrested led lysis, whereas overproduction inhibited formation enlarged cells. We report S. aureus GpsB, unlike other...
Monitoring the extracellular environment for danger signals is a critical aspect of cellular survival. However, released by dying bacteria and mechanisms use threat assessment remain largely unexplored. Here, we show that lysis Pseudomonas aeruginosa cells releases polyamines are subsequently taken up surviving via mechanism relies on Gac/Rsm signaling. While intracellular spike in cells, duration this varies according to infection status cell. In bacteriophage-infected maintained at high...
Abstract Prophages are prevalent features of bacterial genomes that can reduce susceptibility to lytic phage infection, yet the mechanisms involved often elusive. Here, we identify a small RNA ( svsR ) encoded by lambdoid prophage NC-SV in adherent-invasive Escherichia coli (AIEC) strain NC101 confers resistance coliphages. Comparative genomic analyses revealed NC-SV–like prophages and homologs conserved across diverse Enterobacteriaceae. Transcriptional reveal represses maltodextrin...
Abstract Through continuous efforts in developing a new class of foldamers, homogeneous sulfono‐γ‐AApeptides have been designed and synthesized using tetraphenylethylene (TPE) moieties attached to the backbone as luminogenic sidechains. Based on previous crystal structures, it is found that these foldamers adopted left‐handed 4 14 ‐helix. Due constraint helical scaffold, rotation TPE restricted, leading fluorescent emissive properties with high quantum yields not only at aggregate state but...
Staphylococcus aureus is a public health threat due to the prevalence of antibiotic resistance and capacity this organism infect numerous organs in vertebrates. To generate energy needed proliferate within tissues, S. transitions between aerobic respiration fermentation. Fermentation results distinct colony morphology called small-colony variant (SCV) decreased membrane potential ATP production. These traits promote increased aminoglycoside antibiotics. Consequently, SCVs are associated with...
Bacteria adapt to different environments by regulating cell division and several conditions that modulate have been documented. Understanding how bacteria transduce environmental signals control is critical comprehend the global network of regulation. In this article we describe a role for Bacillus subtilis YpsA, an uncharacterized protein SLOG superfamily nucleotide ligand-binding proteins, in division. We observed YpsA provides protection against oxidative stress as cells lacking ypsA show...
Investigations of factors influencing cell division and shape in bacteria are commonly performed conjunction with high-resolution fluorescence microscopy as observations made at a population level may not truly reflect what occurs single level. Live-cell timelapse allows investigators to monitor the changes or morphology which provide valuable insights regarding subcellular localization proteins timing gene expression, it happens, potentially aid answering important biological questions....
In this study, a method of supercritical fluid extraction (SFE) with carbon dioxide polyisoprenoids from plant photosynthetic tissues is described. SFE was an effective for short- and medium-chain compounds even higher yield than that observed the "classical extraction" organic solvents. Moreover, SFE-derived extracts contained lower amounts impurities (e.g., chlorophylls) those obtained by same tissue Elevated temperature extended time resulted in rate long-chain polyisoprenoids. Ethanol...
Acinetobacter baumannii is a formidable opportunistic pathogen that notoriously difficult to eradicate from hospital settings. This resilience often attributed proclivity for biofilm formation, which facilitates higher tolerance toward external stress, desiccation, and antimicrobials. Despite this, little known regarding the mechanisms orchestrating A. formation. Here, we performed RNA sequencing (RNA-seq) on planktonic populations multidrug-resistant isolate AB5075 identified 438 genes with...