A5007964756- Insect Resistance and Genetics
- Mosquito-borne diseases and control
- Invertebrate Immune Response Mechanisms
- Neurobiology and Insect Physiology Research
- Insect symbiosis and bacterial influences
- Computational Drug Discovery Methods
- CRISPR and Genetic Engineering
- Neurological Disease Mechanisms and Treatments
- Renal Diseases and Glomerulopathies
- Viral Infections and Vectors
- Effects and risks of endocrine disrupting chemicals
- Malaria Research and Control
- Microbial Community Ecology and Physiology
- Pediatric health and respiratory diseases
- Renal and Vascular Pathologies
- Neuroinflammation and Neurodegeneration Mechanisms
- Microbial bioremediation and biosurfactants
- Redox biology and oxidative stress
- Chronic Kidney Disease and Diabetes
- Cerebrovascular and Carotid Artery Diseases
- Genomics and Phylogenetic Studies
- Free Radicals and Antioxidants
- Medicinal Plants and Bioactive Compounds
- Asthma and respiratory diseases
- Cancer-related gene regulation
Hong Kong University of Science and Technology
2025
University of Hong Kong
2025
Yueyang Hospital
2021-2024
Shanghai University of Traditional Chinese Medicine
2021-2024
Macau University of Science and Technology
2024
Institute of Soil and Water Conservation
2024
Northwest A&F University
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Sun Yat-sen University
2024
Southern Medical University
2015-2023
Female Aedes aegypti mosquitoes infect more than 400 million people each year with dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in understanding the biology of developing tools to fight them has been slowed by lack a high-quality genome assembly. Here we combine diverse technologies produce markedly improved, fully re-annotated AaegL5 assembly, demonstrate how it accelerates mosquito science. We anchored physical cytogenetic maps, doubled number...
The Asian tiger mosquito, Aedes albopictus, is a highly successful invasive species that transmits number of human viral diseases, including dengue and Chikungunya fevers. This has large genome with significant population-based size variation. complete sequence was determined for the Foshan strain, an established laboratory colony derived from wild mosquitoes southeastern China, region within historical range origin species. comprises 1,967 Mb, largest mosquito sequenced to date, its results...
To further understand the biology of rhinovirus (RV), we determined whether IL-6 was produced during RV infections and characterized mechanism by which stimulates lung cell production. In contrast to normals minimally symptomatic volunteers, detected in nasal washings from patients who developed colds after challenge. RV14 RV1A, major minor receptor group RVs, respectively, were potent stimulators protein production vitro. These effects associated with significant increases mRNA accumulation...
Aedes albopictus (Skuse) is an invasive mosquito that has become important vector of chikungunya, dengue and Zika viruses. In the absence specific antiviral therapy or a vaccine, management sole method available for reducing Aedes-induced disease morbidity. Determining resistance status Ae. to insecticides exploring mechanisms essential future control planning. larvae pupae were sampled from six sites (two each urban, suburban rural) in Guangzhou. The bioassays conducted against Bacillus...
Chromosomes are hierarchically folded within cell nuclei into territories, domains and subdomains, but the functional importance evolutionary dynamics of these hierarchies poorly defined. Here, we comprehensively profile genome organizations five Anopheles mosquito species show how different levels chromatin architecture influence each other. Patterns observed on Hi-C maps associated with known cytological structures, epigenetic profiles, gene expression levels. Evolutionary analysis reveals...
Abstract Background Atrial fibrillation (AF) is a prevalent arrhythmic condition resulting in increased stroke risk and associated with high mortality. Electrolyte imbalance can increase the of AF, where relationship between AF serum electrolytes remains unclear. Methods A total 15,792 individuals were included observational study, incident ascertainment Atherosclerosis Risk Communities (ARIC) study. The Cox regression models applied to calculate hazard ratio (HR) 95% confidence interval...
Neutrophil infiltration is a well-documented early event in the pathogenesis of rhinovirus (RV) infections. To further understand mechanisms responsible for this neutrophilia, we determined whether interleukin (IL)-8 was present at sites experimental RV infection vivo and characterized mechanism(s) by which stimulates IL-8 production vitro. readily detectable nasal washings all normal volunteers did not increase with sham inoculation. In contrast, caused significant additional IL-8, levels...
Abstract Interactions between bacterial microbiota and mosquitoes play an important role in mosquitoes’ capacity to transmit pathogens. However, assemblages within the impact of environments on mosquito development survival remain unclear. This study examined effects aquatic environment larval Aedes albopictus mosquito, dengue virus vector. Life table studies have found that reducing load natural habitats through water filtering treatment with antibiotics significantly reduced larva‐to‐adult...
Background: Cerebral small vessel disease (CSVD) is a group of clinical syndromes covering all pathological processes vessels in the brain, which can cause stroke and serious dementia. However, as pathogenesis CSVD not clear, so treatment limited. Endothelial cell dysfunction earlier than symptoms, such hypertension leukosis. Therefore, endothelial cells expected to be new breakthrough. Quercetin, flavonoid present variety plants, has function anti-inflammation anti-oxidation. This study...
Inflammation and smooth muscle abnormalities coexist in human airway disorders, inflammation modulates the proliferative contractile properties of cells. To determine whether (HASM) cells have ability to regulate local inflammatory processes, we characterized interleukin (IL)-6-type cytokine production HASM vitro. We demonstrated that are potent producers IL-11 when stimulated with IL-1 or transforming growth factor-beta 1 (TGF-beta 1) levels synergistically increased by TGF-beta...
In eukaryotic organisms, Piwi-interacting RNAs (piRNAs) control the activities of mobile genetic elements and ensure genome maintenance. Recent evidence indicates that piRNAs are involved in multiple biological pathways, including transcriptional regulation protein-coding genes, sex determination even interactions between host pathogens. Aedes albopictus is a major invasive species transmits number viral diseases humans. Ae. has largest highest abundance repetitive sequences when compared...
Background Aedes albopictus is one of the most invasive species in world as well important vector for mosquito-borne diseases such dengue fever, chikungunya fever and zika virus disease. Chemical control mosquitoes an effective method to diseases, however, wide improper application insecticides has led serious resistance problems. At present, there have been many reports on pyrethroid including deltamethrin . However, fitness cost competence resistant remain unknown. To understand impact...
Cilia are highly conserved cellular organelles extruding from the surface of cell types carrying either sensory (signaling) or motile functions. These include photoreceptor cells and airway epithelia, where they function in light sensation mucociliary clearance respectively. Retinitis pigmentosa GTPase regulator (RPGR) variants affect both cilia cilia, leading to retinitis (RP) some cases, primary ciliary dyskinesia (PCD), debilitating conditions. Not all patients develop PCD it is unclear...
The aim of the present study was to identify association between pathological types kidney and clinical manifestations in patients with hypertensive nephropathy. blood pressure, fundus, urinalysis test results renal function changes were analysed who treated for Downward puncture biopsy performed using a 16G ejection needle aid B ultrasound 47 cases. specimens observed light microscopy immunofluorescence. exhibiting symptoms nephropathy varied. majority benign arteriolar nephrosclerosis,...
Background: Stroke is the second leading cause of death in human life health, but current treatment strategies are limited to thrombolytic therapy, and because tight time window, many contraindications, only a very small number people can benefit from it, new therapeutic needed solve this problem. As physical barrier between central nervous system blood, blood-brain (BBB) maintains homeostasis system. Maintaining integrity BBB may emerge as strategy. Liquiritin (LQ) flavonoid isolated...
Abstract Metagenomic binning enables the in-depth characterization of microorganisms. To improve resolution and efficiency metagenomic binning, BASALT (Binning Across a Series AssembLies Toolkit), novel toolkit was present in this study, which recovers, compares optimizes assembled genomes (MAGs) across series assemblies from short-read, long-read or hybrid strategies. incorporates self-designed algorithms automates separation redundant bins, elongate refine best bins contiguity. Evaluation...
Abstract Colorectal cancer (CRC) is the second leading cause of mortality worldwide. However, molecular mechanisms underlying CRC progression remain to be further defined improve patient outcomes. In this study, we found that KCTD9, a member potassium channel tetramerization domain-containing ( KCTD ) gene family, was commonly downregulated in tissues and KCTD9 expression negatively correlated with clinical stage. Survival analysis showed patients whose tumors expressed low levels had poorer...
Abstract Chaenomeles speciosa is a plant with high ornamental value, and the color of its petals deepens obviously under drought stress. To understand mechanism drought‐induced reddening C. petal color, metabolites transcriptomics from 4% PEG‐8000‐treated control cuttings were analyzed. In this study, analysis revealed accumulation anthocyanins in PEG‐treated cuttings, indicating might be reason for deepening color. By using transcriptomics, we identified CsMYB6 as an overexpressed...
To explore the impact of inflammatory factors on incidence cerebral small vessel disease (CSVD), we performed a mendelian randomization (MR) study to analyze causal relationship between multiple and CSVD imaging markers utilized summary-data-based (SMR) analysis infer whether instrumental variables (IVs) is mediated by gene expression or DNA methylation.
Due to the substantial production and use of antibiotics, they inevitably remain in aquatic environments, posing a serious threat ecosystems. However, there are currently no criteria antibiotics for ecological risk water environment. In present study, three types (tetracyclines, sulfonamides quinolones) that often detected environments were investigated. Toxicity data regarding bacteria, algae, plants, invertebrates vertebrates selected, species sensitivity distribution was used obtain...