Raissa G. G. Kay
A5001220321- Mosquito-borne diseases and control
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Insect symbiosis and bacterial influences
- Sexual Differentiation and Disorders
- CRISPR and Genetic Engineering
- Insect Resistance and Genetics
- Invertebrate Immune Response Mechanisms
- Urological Disorders and Treatments
- Malaria Research and Control
- Renal and related cancers
Mary Lyon Centre at MRC Harwell
2019-2024
Medical Research Council
2019
University of California, Riverside
2017-2018
Female Aedes aegypti mosquitoes infect more than 400 million people each year with dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in understanding the biology of developing tools to fight them has been slowed by lack a high-quality genome assembly. Here we combine diverse technologies produce markedly improved, fully re-annotated AaegL5 assembly, demonstrate how it accelerates mosquito science. We anchored physical cytogenetic maps, doubled number...
XY individuals with disorders/differences of sex development (DSD) are characterized by reduced androgenization caused, in some children, gonadal dysgenesis or testis regression during fetal development. The genetic etiology for most patients 46,XY and all testicular syndrome (TRS) is unknown. We performed exome and/or Sanger sequencing 145 DSD unknown including TRS. Thirteen children carried heterozygous missense pathogenic variants involving the RNA helicase DHX37, which essential ribosome...
Female Aedes aegypti mosquitoes infect hundreds of millions people each year with dangerous viral pathogens including dengue, yellow fever, Zika, and chikungunya. Progress in understanding the biology this insect, developing tools to fight it, has been slowed by lack a high-quality genome assembly. Here we combine diverse technologies produce AaegL5, dramatically improved annotated assembly, demonstrate how it accelerates mosquito science control. We anchored physical cytogenetic maps,...
Testes-biased genes evolve rapidly and are important in the establishment, solidification, maintenance of reproductive isolation between incipient species. The
ABSTRACT The role of anti-WNT ZNRF3 is central to determining gonadal fate: XY mice lacking functional exhibit a highly variable sex reversal phenotype in the fetal period, characterised by appearance ovarian tissue. To investigate this further, we used single-cell RNA-seq examine transcriptomes Znrf3-deficient gonads during mouse sex-determining period. Analyses cell trajectories mutant reveal failure pre-supporting cells commit Sertoli fate, granulosa development, unstable commitment those...