A5006253369- Cancer-related molecular mechanisms research
- Mycobacterium research and diagnosis
- Gastric Cancer Management and Outcomes
- Ubiquitin and proteasome pathways
- interferon and immune responses
- TGF-β signaling in diseases
- Liver physiology and pathology
- Esophageal and GI Pathology
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Renin-Angiotensin System Studies
- Colorectal and Anal Carcinomas
- Microtubule and mitosis dynamics
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Surgical Treatments
- Cancer Mechanisms and Therapy
- Enhanced Recovery After Surgery
- Immunotherapy and Immune Responses
- Cancer-related gene regulation
- Cell Adhesion Molecules Research
- Radiomics and Machine Learning in Medical Imaging
- Angiogenesis and VEGF in Cancer
- Gastrointestinal Tumor Research and Treatment
- Wnt/β-catenin signaling in development and cancer
- Cancer, Hypoxia, and Metabolism
Anhui Provincial Hospital
2012-2024
Anhui Medical University
2011-2024
University of Science and Technology of China
2018-2024
Bozhou People's Hospital
2024
HMGA2, a pivotal transcription factor, functions as versatile regulator implicated in the progression of diverse aggressive malignancies. In this study, mass spectrometry was employed to identify ubiquitin-specific proteases that potentially interact with and USP48 identified deubiquitinating enzyme HMGA2. The enforced expression significantly increased HMGA2 protein levels by inhibiting its degradation, while deprivation promoted thereby suppressing tumor invasion metastasis. We discovered...
BACKGROUND The aim of this study was to investigate the expression level martrilin-3 (MATN3) in patients with gastric adenocarcinoma (GAC) and prognostic significance MATN3. MATERIAL AND METHODS Gene Expression Omnibus (GEO) Cancer Genome Atlas (TCGA) data were used predict value MATN3 mRNA GAC patients. Seventy-six had tissue samples paired adjacent normal collected retrospectively examine protein by immunohistochemical staining. Furthermore, Kaplan-Meier univariate Cox multivariate...
Abstract Colorectal cancer (CRC) is the second leading cause of mortality worldwide. However, molecular mechanisms underlying CRC progression remain to be further defined improve patient outcomes. In this study, we found that KCTD9, a member potassium channel tetramerization domain-containing ( KCTD ) gene family, was commonly downregulated in tissues and KCTD9 expression negatively correlated with clinical stage. Survival analysis showed patients whose tumors expressed low levels had poorer...
Abstract Interferon (IFN) exerts its effects through interferon-stimulated genes (ISGs), but efficacy is limited by interferon resistance, which can be caused the ubiquitination of key proteins. UBE2O was initially identified as a promising therapeutic target based on data from TCGA and iUUCD 2.0 databases. Through inhibition UBE2O, α/β signaling overall were activated. Integrating proteomic, mass spectrometry, survival analyses led to identification IFIT3, mediator signaling, substrate...
Objective: Unusual clinical course Background:Pyloric obstruction after dichlorvos poisoning causes repeated vomiting and inability to eat.Choledocholithiasis cholelithiasis are the common digestive diseases, with high morbidity relapse in elderly patients.However, complex situation of these diseases' coexistence is a clinically intractable problem, literature on selecting optimal surgical planning scarce. Case Report:A thin 79-year-old woman took due family conflicts.She improved being...
BACKGROUND Angiogenic factor with G-patch and FHA domain1 (AGGF1 or VG5Q) is a newly identified human angiogenic factor. The aim of this study was to explore AGGF1 expression level in gastric cancer detect its correlation the prognosis. MATERIAL AND METHODS Immunohistochemistry performed adjacent noncancerous samples 198 cases, relationships among levels AGGF1, vascular endothelial growth (VEGF), prognosis were analyzed. RESULTS Expression significantly higher than that (P<0.001). overall...
Angiogenic factor with G-patch and FHA domain 1 (AGGF1), as a newly identified human angiogenic factor, is overexpressed in some types of malignant tumors closely associated patient's prognosis. However, the mechanisms involved regulation AGGF1 gastric cancer (GC) still remain unclear.In this study, level GC tissues cell lines was analyzed by western blot quantitative real-time polymerase chain reaction (qRT-PCR). After knockdown AGGF expression RNA interference MKN-45 MGC-803, wound healing...
Laparoscopic radical gastrectomy has been increasingly applied in China. However, how to reduce surgery-related trauma, shorten operative time and achieve the long-term prognosis equal conventional open surgery is still hot research topics. Along with change learning curve optimization of endoscopic techniques, laparoscopic lymph node dissection can or even exceed extent that be achieved surgery. Therefore, it gradually replaced digestive tract reconstruction using an auxiliary incision. By...
BACKGROUND Cryptogenic multifocal ulcerating stenosing enteropathy (CMUSE) is a rare noninfectious chronic inflammatory disease of the digestive tract confined to small bowel. Chronic wasting leads protein loss and weight reduction, some patients eventually develop bowel stenosis. The etiopathogenesis CMUSE remains unknown. CASE REPORT A thin 62-year-old man was admitted hospital with abdominal pain distension accompanied by bilateral lower-extremity edema for 2 months. After series medical...
In order to explore the colorectal cancer during perioperative period based on structure model of artificial neural network, and provide reference for selection nursing measures patients with cancer, network models rectal colon different nutritional interventions biomedicine were established. 264 accelerated rehabilitation group. There 132 in each group who given intervention compare quality life after nursing. The results suggested that had a certain value predicting impact patients’ life....
Laparoscopic radical gastrectomy has been increasingly applied in China. However, how to reduce surgery-related trauma, shorten operative time and achieve the long-term prognosis equal conventional open surgery is still hot research topics. Along with change learning curve optimization of endoscopic techniques, laparoscopic lymph node dissection can or even exceed extent that be achieved surgery. Therefore, it gradually replaced digestive tract reconstruction using an auxiliary incision. By...
Type Ⅱ transmembrane serine proteases 4 (TMPRSS4) is a novel type protease.Present study showed that its expression was related with tumor invasion and metastasis,although oncogenic significance molecular mechanisms are still unknown.In this review,the author try to introduce structure,biological function mechanism in metastasis. Key words: TMPRSS4 ; EMT; Invasion; Neoplasm metastasis Biology Serine