A5101529455- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Aquaculture disease management and microbiota
- Aquaculture Nutrition and Growth
- RNA Research and Splicing
- Nanoplatforms for cancer theranostics
- Circular RNAs in diseases
- Ferrocene Chemistry and Applications
- Biochemical Analysis and Sensing Techniques
- Adipose Tissue and Metabolism
- Angiogenesis and VEGF in Cancer
- Extracellular vesicles in disease
- Physiological and biochemical adaptations
- Pancreatic function and diabetes
- NF-κB Signaling Pathways
- Advanced Fluorescence Microscopy Techniques
- Ion-surface interactions and analysis
- Luminescence and Fluorescent Materials
- Mass Spectrometry Techniques and Applications
- Cytokine Signaling Pathways and Interactions
- Spectroscopy Techniques in Biomedical and Chemical Research
- Immune Response and Inflammation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Autophagy in Disease and Therapy
Hunan Normal University
2020-2024
South China Agricultural University
2024
Key Laboratory of Guangdong Province
2024
Third Xiangya Hospital
2016-2023
Central South University
2012-2023
Wuhan National Laboratory for Optoelectronics
2019
Huazhong University of Science and Technology
2019
Anhui Provincial Hospital
2018
University of Science and Technology of China
2018
Guangzhou Medical University
2014
Colorectal carcinoma (CRC) is a common malignant tumor. Increasing evidences indicated that CRC showed resistance to 5-fluorouracil (5-FU) and further resulted in poor prognosis. In this study, we aim investigate the effect of long noncoding RNA nuclear paraspeckle assembly transcript 1 (LncRNA NEAT1) on cell viability, sensitivity 5-FU, autophagy lines.MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-Htetrazolium bromide) was used detect immunofluorescent staining puncta, luciferase...
<title>Abstract</title> MicroRNAs (miRNAs) are small non-coding RNAs that participate in the spatiotemporal regulation of messenger RNA and protein synthesis. Aberrant miRNA expression leads to developmental abnormalities diseases. The miR-135a is considered be oncogenic; however, functions mechanisms colorectal cancer (CRC) largely unknown. Thus, we investigated miR-135a, especially its relationship with metastasis suppressor 1 (<italic>MTSS1</italic>) gene CRC. was determined by real-time...
Colorectal cancer (CRC) is one of the most common malignancies in world, with a high incidence and mortality. However, pathogenesis CRC carcinogenesis still unexplored. In this study, we investigated role miR-107 regulation cell proliferation apoptosis. First, expression was observed to be aberrantly increased human tumor tissues lines when compared colonic control colon epithelial cells. Further study showed that proliferative apoptotic capacities SW480 LoVo cells were regulated by miR-107....
Disease-resistant grass carp (DR-GGC) was obtained by backcrossing gynogenetic (GGC, 2n = 48, female) with common (Ctenopharyngodon idellus [GC], male). The genetic constitution and the potential mutation associated growth dominance in DR-GGC were analyzed genomic situ hybridization (GISH), whole-genome resequencing (WGRS) RNA-sequencing (RNA-seq). GISH results showed partial translocations deletions chromosomes of compared GC. WGRS demonstrated that there numerous variations between its...
Melanocortin-4 receptor (MC4R) plays important roles in regulation of multiple physiological processes, and interaction MC4R melanocortin accessory protein 2 (MRAP2) is suggested to play pivotal role energy balance vertebrates. Topmouth culter (Culter alburnus) an economically freshwater fish China. Herein we cloned mc4r, mrap2a, mrap2b. Culter mc4r consisted a 981 bp open reading frame encoding 326 amino acids. qRT-PCR revealed that mrap2b were primarily expressed the central nervous...
Abstract High detection sensitivity and resolution are two critical parameters for recording good peptide mass fingerprints (PMF) of low abundance proteins. This paper reports a spectrometry (MS) sample preparation technique that could improve resolution. By coating the MS steel target with thin layer pentadecafluorooctamido propyltrimethoxysilane, which was both polar nonpolar solvent repellent, transferred droplets on its surface were significantly smaller. As result, analyte mixture...
Colon cancer (CC) is among the most common malignant diseases with a dismal survival. Tumor necrosis factor-alpha (TNF-α) has been identified as therapeutic target in various cancers, and anti-TNF-α treatment shown promising effects different models. However, if TNF-α can be targeted CC, values of CC remain unknown. Our study indicated that highly expressed cell lines patient tumor samples. High expression an independent adverse prognosticator CC. Targeting by its antibody infliximab induced...
Loss-of-function of succinate dehydrogenase-B (SDHB) is a predisposing factor aerobic glycolysis and cancer progression. Adenosine monophosphate activated protein kinase (AMPK) involved in the regulation diverse hallmarks cancer. The present study investigated whether AMPK mediated regulatory effects SDHB growth. expression colorectal (CRC) normal tissues was assessed by western blotting. HT-29 CRC cells were used to establish vitro models ectopic overexpression knockdown SDHB....
Abstract Kringle 5(K5) is the fifth kringle domain of human plasminogen and its anti‐angiogenic activity more potent than angiostatin that includes first four fragment plasminogen. Our recent study demonstrated K5 suppressed hepatocarcinoma growth by anti‐angiogenesis. To find high efficacy minimal peptide sequence required for anti‐tumour activities K5, two deletion mutants were generated. The amino acid residues outside intact (Pro452‐Ala542) deleted to form K5mut1(Cys462‐Cys541). residue...