A5056851826- Angiogenesis and VEGF in Cancer
- Congenital heart defects research
- Cancer-related molecular mechanisms research
- Protease and Inhibitor Mechanisms
- MicroRNA in disease regulation
- Retinal Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Blood Coagulation and Thrombosis Mechanisms
- Cancer, Lipids, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Tissue Engineering and Regenerative Medicine
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Adipose Tissue and Metabolism
- Circular RNAs in diseases
- Atherosclerosis and Cardiovascular Diseases
- Liver Disease Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Cancer, Hypoxia, and Metabolism
- Connexins and lens biology
- Orthopaedic implants and arthroplasty
- Lipoproteins and Cardiovascular Health
- Pluripotent Stem Cells Research
- Cholesterol and Lipid Metabolism
- Cardiac Valve Diseases and Treatments
Sun Yat-sen University
2014-2024
Guangdong Provincial Hospital of Traditional Chinese Medicine
2023-2024
South China University of Technology
2023
The Seventh Affiliated Hospital of Sun Yat-sen University
2022-2023
Fuzhou University
2020-2023
Quanzhou Institute of Equipment Manufacturing Haixi Institute
2023
Chinese Academy of Sciences
2023
China University of Mining and Technology
2023
Sichuan Highway Design and Research Institute
2022
Guangzhou University of Chinese Medicine
2016-2022
Identifying a bona fide population of cardiac stem cells (CSCs) is critical step for developing cell-based therapies heart failure patients. Previously, c-kit(+) were reported to be CSCs with potential become myocardial, endothelial and smooth muscle in vitro after injury. Here we provide further insights into the nature cells. By targeting c-kit locus multiple reporter genes mice, find that expression rarely co-localizes progenitor myogenic marker Nkx2.5, or myocardial marker, troponin T...
Abstract Statins play an important role in the treatment of diabetic nephropathy. Increasing attention has been given to relationship between statins and insulin resistance, but many randomized controlled trials confirm that therapeutic effects on nephropathy are more beneficial than harmful. However, further confirmation whether chronic statin administration outweigh detrimental is urgently needed. Here, we find long-term may increase interfere with lipid metabolism, leads inflammation...
Esophageal cancer (EC) is one of the most common gastrointestinal cancers, which leads to sixth ranking cancer-related death. Long non-coding RNAs (lncRNAs) play pivotal roles in many biological processes. lncRNA human urothelial carcinoma associated 1 (UCA1) significantly upregulated and functions as an important oncogene types cancers. However, role UCA1 EC its underlying mechanism remains unclear. In present study, we demonstrated that was tissues with poor prognosis. Overexpression...
High calorie intake is known to induce nonalcoholic fatty liver disease (NAFLD) by promoting chronic inflammation. However, the mechanisms are poorly understood. This study examined roles of ANGPTL8 in regulation NAFLD-associated fibrosis progression induced high fat diet (HFD)-mediated The concentration was measured serum samples from cancer and cirrhosis patients. knockout(KO) mice were used models (HFD, HFHC CCL4) followed pathological staining, western blot immunohistochemistry....
Abstract Diabetic cardiomyopathy is a primary myocardial injury induced by diabetes with complex pathogenesis. In this study, we identify disordered cardiac retinol metabolism in type 2 diabetic male mice and patients characterized overload, all-trans retinoic acid deficiency. By supplementing or acid, demonstrate that both overload deficiency promote cardiomyopathy. Mechanistically, constructing cardiomyocyte-specific conditional dehydrogenase 10-knockout overexpressing 10 via...
Obesity and associated metabolic diseases are characterized by a chronic low-grade inflammatory state with the infiltration of many cells, especially macrophages. Immune molecules, including some cytokines, have close relationship metabolism. Interleukin (IL)-25 is member IL-17 cytokine family that can regulate macrophages alleviate dysfunction; however, its role mechanisms in lipid metabolism remain to be extensively clarified. Human serum liver biopsy specimens, high-fat diet-induced...
Cardiac valves are essential to direct forward blood flow through the cardiac chambers efficiently. Congenital valvular defects prevalent among newborns and can cause an immediate threat survival as well long-term morbidity. Valve leaflet formation is a rigorously programmed process consisting of endocardial epithelial-mesenchymal transformation (EMT), mesenchymal cell proliferation, valve elongation remodeling. Currently, little known about coordination diverse signals that regulate cushion...
Background: Little is known about the pathophysiological diversity of myocardial injury in type 2 diabetes mellitus (T2DM), but analyzing these differences important for accurate diagnosis and precise treatment diabetic cardiomyopathy. This study aimed to elucidate key cardiac between obese non-obese T2DM from mice humans. Methods: Obese mouse models were successfully constructed observed until systolic dysfunction occurred. Changes structure, function, energy metabolism oxidative stress...
Without therapeutic intervention, corneal neovascularization rapidly compromises visual acuity, and is a leading cause of blindness. Artesunate was reported to inhibit angiogenesis in tumors, although, the effects artesunate on nontumor have not been investigated. This study designed investigate effect delineate its underlying mechanism action.Rats with alkali-burned corneas were treated for 11 days. Corneal evaluated by measuring length area vasculature rats. Apoptotic cells stained...
As a biological pump, the heart needs to consume substantial amount of energy maintain sustained beating. Myocardial metabolism was recently reported be related loss proliferative capacity in cardiomyocytes (CMs). However, intrinsic relationship between beating rate and proliferation CMs whether can regulate this remains unclear. In study, we find that moderate reduction (HRR) induces CM under physiological conditions promotes cardiac regenerative repair after myocardial injury....
Pigment epithelium-derived factor (PEDF), an angiogenesis inhibitor with multiple other functions, balances in the eye and blocks tumor progression. Retinoblastoma, angiogenesis-dependent tumor, is most common ocular cancer children without effective treatment. It has been reported that PEDF can induce neuronal differentiation of retinoblastoma cells; however, its anti-angiogenic potential for inhibition growth vivo not elucidated. The present study was designed to investigate effect on...