A5015787554- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
- SARS-CoV-2 and COVID-19 Research
- Gut microbiota and health
- Circular RNAs in diseases
- Diet and metabolism studies
- Cancer, Lipids, and Metabolism
- Metabolism, Diabetes, and Cancer
- Phagocytosis and Immune Regulation
- Cancer-related molecular mechanisms research
- Diet, Metabolism, and Disease
- Cancer, Hypoxia, and Metabolism
- Tuberculosis Research and Epidemiology
- Diagnosis and treatment of tuberculosis
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Gout, Hyperuricemia, Uric Acid
- Cholesterol and Lipid Metabolism
- Biomarkers in Disease Mechanisms
- interferon and immune responses
- Rheumatoid Arthritis Research and Therapies
- Biochemical Acid Research Studies
- Mycobacterium research and diagnosis
- Complement system in diseases
Sun Yat-sen University
2024
University of South China
2023-2024
Changsha Central Hospital
2023-2024
Purpose: Myocardial ischemic reperfusion injury (MIRI) is a crucial clinical problem globally.The molecular mechanisms of MIRI need to be fully explored develop new therapeutic methods.Galangin (Gal), which natural flavonoid extracted from Alpinia Officinarum Hance and Propolis, possesses wide range pharmacological activities, but its effects on remain unclear.This study aimed determine the Gal MIRI.Methods: C57BL/6 mice underwent for 3 h after 45 min ischemia, neonatal rat cardiomyocytes...
Abstract Background Quinic acid (QA) and its derivatives have good lipid-lowering hepatoprotective functions, but their role in atherosclerosis remains unknown. This study attempted to investigate the mechanism of QA on atherogenesis Apoe−/− mice induced by HFD. Methods HE staining oil red O were used observe pathology. The PCSK9, Mac-3 SM22a expressions detected IHC. Cholesterol, HMGB1, TIMP-1 CXCL13 levels measured biochemical ELISA. Lipid metabolism HMGB1-SREBP2-SR-BI pathway PCR WB. 16 S...
Worldwide, lung cancer is the most common cause of cancer-related death, which made worse by development drug resistance during treatment. It urgent to develop new therapeutic methods and small molecule drugs for tumor resistance. Chaetocin, extracted from Chaetomium minutum, a natural compound with good antitumor activity. However, there are few studies on its In this paper, firstly, chaetotocin significantly inhibited viability migration cisplatin-resistant non-small cell (NSCLC) cells...
Interferon-gamma (IFN-γ) release assays (IGRAs) are used to diagnose tuberculosis (TB) but not measure treatment response.
Syndecan-1 (SDC-1) was a critical membrane proteoglycan and an important component of the glycocalyx in endothelial cells, but its role atherosclerosis remains unknown. This study attempted to investigate SDC-1 atherosclerotic-related cell injury. Bioinformatics analyzed differential miRNAs between healthy. Subjects with coronary atherosclerosis, which were diagnosed intravascular (IVUS), enrolled as non-vulnerable plaque vulnerable Changsha Central Hospital. Human aortic cells (HAECs)...
T helper cells, particularly follicular (T
Nuclear factor κB (NF-κB) plays a crucial role in various cellular processes, including inflammatory and immune responses. Its activation is tightly regulated by the IKK (IκB kinase) complex. Upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, virus initially recognized innate system typically activates NF-κB pathway, leading to response. However, influence of viral proteins upon pro-inflammatory pathway complicated. Here, we demonstrated that protein nsp3 SARS-CoV-2...
Ferroptosis is intricately associated with the pathophysiology processes of myocardial ischemia. Cardamonin (CAR) has been shown to provide significant protection against tissue damage due multiple ischemia/reperfusion. This study aimed examine cardioprotective properties CAR in ischemia/reperfusion injury (MIRI) and insights into possible mechanisms involved.
Objective: to investigate the clinical characteristics and disease activity in ankylosing spondylitis (AS) patients with hyperuricemia. Method: Laboratory tests, magnetic resonance imaging, functional index of AS from Fudan University Zhongshan Hospital were collected. T test, square test applied difference between hyperuricemia normal serum uric acid patients. Result: Among all patients, 23.4% (22/94) accompanied showed significant younger age (28.9±7.9 vs 35.8±11.1, P=0.002); higher...