A5018068367- Congenital heart defects research
- Pluripotent Stem Cells Research
- Tissue Engineering and Regenerative Medicine
- Cardiomyopathy and Myosin Studies
- Cardiac Fibrosis and Remodeling
- Healthcare Technology and Patient Monitoring
- Healthcare cost, quality, practices
- Drug-Induced Adverse Reactions
- Medical Coding and Health Information
- Chronic Disease Management Strategies
- Retinoids in leukemia and cellular processes
- Amino Acid Enzymes and Metabolism
- Pharmaceutical industry and healthcare
- Social Media in Health Education
- Clinical practice guidelines implementation
Royal College of Surgeons in Ireland
2018
Icahn School of Medicine at Mount Sinai
2015-2016
Child Health and Development Institute
2015
Identifying a bona fide population of cardiac stem cells (CSCs) is critical step for developing cell-based therapies heart failure patients. Previously, c-kit(+) were reported to be CSCs with potential become myocardial, endothelial and smooth muscle in vitro after injury. Here we provide further insights into the nature cells. By targeting c-kit locus multiple reporter genes mice, find that expression rarely co-localizes progenitor myogenic marker Nkx2.5, or myocardial marker, troponin T...
A mouse model that mediates temporal, specific, and efficient myocardial deletion with Cre-LoxP technology will be a valuable tool to determine the function of genes during heart formation. Mhy6 encodes cardiac muscle specific protein: alpha-myosin heavy chain. Here, we generated new Myh6-MerCreMer (Myh6MerCreMer/+) inducible Cre knock-in by inserting MerCreMer cassette into Myh6 start codon. By crossing mice Rosa26 reporter lines, found Myh6MerCreMer/+ mediate complete recombination in...
Introduction: Pharmacovigilance may detect safety issues after marketing of medications, and this can result in regulatory action such as direct healthcare professional communications (DHPC). DHPC be effective changing prescribing behaviour, however the extent to which prescribers vary their response is unknown. This study aims explore changes variation among general practitioner (GP) practices following a on mirabegron, medication treat overactive bladder (OAB). Methods: an interrupted time...
Introduction Pharmacovigilance may detect safety issues after marketing of medications, and this can result in regulatory action such as direct healthcare professional communications (DHPC). DHPC be effective changing prescribing behaviour, however the extent to which prescribers vary their response is unknown. This study aims explore changes variation among GP practices following a on mirabegron, medication treat overactive bladder (OAB). Methods an interrupted time series English from...
Identifying a bona fide population of cardiac stem cells (CSCs) is critical step for developing cell-based therapies heart failure patients. For more than decade, c-kit, receptor tyrosine kinase expressed in certain types hematopoietic cells, has been recognized as marker resident CSCs mammals. It was shown that c-kit + are multipotent, with differentiation potential to become cardiomyocytes, endothelial, and smooth muscle vitro after injury. Here, we provide new insights into the nature...